Searchable abstracts of presentations at key conferences in endocrinology

ea0056p224 | Calcium & Vitamin D metabolism | ECE2018

Clinical manifestation of Hypoparathyroidism in a monocentric cohort: our experience

Repaci Andrea , Altieri Paola , Dianori Francesco , Salituro Nicola , Vandi Giulia , Pagotto Uberto

Introduction: Hypoparathyroidism (HP) is characterized by low serum calcium and increased phosphate levels associated with inappropriately low serum PTH levels. Clinical manifestations of HP are tingling, muscle cramps, seizures, nephrocalcinosis, kidney stone, kidney failure, depression and anxiety.Objective: Quantify the chronic symptoms and complications of HP in our monocentric cohort.Material and methods: We conducted a retros...

ea0056p889 | Adrenal cortex (to include Cushing's) | ECE2018

Are there specific biomarkers able to differentiate non classical congenital adrenal hyperplasia (NCAH) due to 21-hydroxylase deficiency from non-NCAH in a population of naive hyperandrogenic women in the reproductive age?

Oriolo Claudia , Menabo Soara , Baldazzi Lilia , Castelli Silvia , Pagotto Uberto , Mezzullo Marco , Fanelli Flaminia , Gambineri Alessandra

Objective: This study was aimed to evaluate the prevalence of non classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-NCAH) in hyperandrogenic women in the reproductive age attending our Endocrinology Unit and to identify specific phenotypic traits among clinical, biochemical and hormonal features.Setting: Outpatient Unit of Endocrinology, S. Orsola-Malpighi University Hospital of Bologna, Italy.Patients a...

ea0081p29 | Adrenal and Cardiovascular Endocrinology | ECE2022

The changing face of drug-induced adrenal insufficiency in the food and drug administration adverse event reporting system

Raschi Emanuel , Fusaroli Michele , Massari Francesco , Mollica Veronica , Repaci Andrea , Ardizzoni Andrea , Poluzzi Elisabetta , Pagotto Uberto , Di Dalmazi Guido

Importance: Adrenal insufficiency is a life-threatening condition complicating heterogenous disorders across various disciplines, with challenging diagnosis and a notable drug-induced component.Objective: To describe the spectrum and main features of drug-induced adrenal insufficiency through adverse drug event reports received by the Food and Drug Administration (FDA).Design: We conducted a retrospective disproportionality analysi...

ea0081p273 | Adrenal and Cardiovascular Endocrinology | ECE2022

Salivary profiles of cortisol and cortisone in patients with primary adrenal insufficiency under replacement therapy: a pilot study

Tucci Lorenzo , Vicennati Valentina , Magagnoli Matteo , Colombin Giacomo , Coscia Kimberly , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Evaluation of steroid replacement therapy (SRT) in adrenal insufficiency (AI) is challenging for the lack of reliable parameters. Measurement of salivary cortisol and cortisone emerged as a non-invasive tool for AI management, however poorly investigated. Aim: To analyse the cortisol and cortisone circadian rhythm in normal controls (NC) and patients with primary AI (PAI) under different SRTs, and to identify useful biomarkers. <p class="...

ea0081p323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sleep quality in patients with type 1 diabetes: a large cross-sectional study

Bongiorno Claudio , Moscatiello Simona , Laffi Gilberto , Ribichini Danilo , Lo Preiato Valentina , Grimaldi Michele , Pagotto Uberto , Di Dalmazi Guido

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...

ea0081p340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Excellent disease control in Berardinelli Seip type 1 patient through dietary therapy alone: only an exception?

Cecchetti Carolina , Belardinelli Elisabetta , Dionese Paola , Teglia Rita , Di Cintio Ilaria , D'apice Maria Rosaria , Pagotto Uberto , Gambineri Alessandra

Background and Objective: Severe metabolic complications generally manifest at an early age in Berardinelli – Seip congenital lipodystrophy (BSCL) and their management is especially challenging, often requiring prompt pharmacological treatment with insulin-sensitizers, lipid lowering drugs, insulin and eventually metreleptin. Nutritional intervention with low lipid personalized diets is considered by experts a fundamental tool in handling the disease when associated with ...

ea0081ep860 | Reproductive and Developmental Endocrinology | ECE2022

A 20-steroid LC-MS/MS panel to investigate classical and backdoor pathways of androgen biosynthesis in the Leydig cells

Magagnoli Matteo , Mezzullo Marco , Limoncella Silvia , Tommasini Alessia , Santi Daniele , Pelusi Carla , Simoni Manuela , Pagotto Uberto , Casarini Livio , Fanelli Flaminia

Background: The classical steroidogenic route to the synthesis of dihydrotestosterone in Leydig cells involves delta-5 and delta-4 precursors. Besides, the “backdoor pathway”, encompassing progesterone metabolites, is gaining increasing interest in fetal development and men pathophysiology. Nowadays, liquid chromatography/tandem mass spectrometry (LC-MS/MS) is the ideal technique to simultaneously quantify large panels of steroids with elevated sensitivity and specif...

ea0081ep879 | Reproductive and Developmental Endocrinology | ECE2022

Daytime salivary androgen rhythm by LC-MS/MS in women affected by Polycystic Ovary Syndrome (PCOS) fulfilling the three Rotterdam diagnostic criteria

Fanelli Flaminia , Hawley James M , Mezzullo Marco , Fazzini Alessia , Zanotti Laura , Magagnoli Matteo , Pagotto Uberto , Keevil Brian , Gambineri Alessandra

Background: Excess testosterone in PCOS is accompanied by increased levels of other ovarian and adrenal androgens and precursors. Recently, 11-oxygenated adrenal androgens have been postulated as major components of the circulating androgen pool in PCOS. Obesity is strictly connected with androgen excess and with the derangement of hormone circadian rhythmicity. To date, it has not been clarified whether hyperandrogenism in PCOS, either complicated by obesity or not, is accomp...

ea0063gp98 | Adrenal and Neuroendocrine - Basic | ECE2019

Methylation status and gene expression of steroidogenic enzymes in benign adrenocortical tumors

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Asioli Sofia , Maffeis Valeria , Vicennati Valentina , Pagotto Uberto , Fallo Francesco

Background: DNA methylation has been recognized as a putative regulatory mechanism for CYP11B2 in primary hyperaldosteronism. We aimed to investigate the DNA methylation and the expression of a panel of genes encoding several enzymes involved in steroidogenesis in adrenocortical benign tumors.Methods: We collected a total of 60 adrenocortical tissues, including 9 non-functioning adrenal adenomas, 9 adenomas associated with autonomous cortisol se...

ea0063gp110 | Calcium and Bone 2 | ECE2019

Denosumab in post-liver transplantation osteoporosis: preliminary data on the effects on bone mineral density and turnover markers

Zavatta Guido , Vandi Giulia , Di Dalmazi Guido , Repaci Andrea , Ravaioli Matteo , Cescon Matteo , Morelli Maria Cristina , Pagotto Uberto , Altieri Paola

Introduction: Several risk factors are involved in post-liver transplantation osteoporosis. Immunosuppressive agents, glucocorticoids, decreased renal function associated with secondary hyperparathyroidism and immobilization are the main determinants of fragility fractures in this population. Denosumab is highly effective in increasing bone mineral density (BMD) and preventing fragility fractures. However, the efficacy of denosumab in liver transplantation osteoporosis has nev...