Searchable abstracts of presentations at key conferences in endocrinology

ea0045p15 | Diabetes | BSPED2016

Severe acute renal failure requiring dialysis in children with diabetic ketoacidosis

Paraskevopoulou Evagelia , Peacock Amanda , Patel Leena , Burren Christine , Yong James , Bain Murray , Wei Christina

Introduction: Acute renal failure (ARF) is a rare but life-threatening complication of severe diabetic ketoacidosis (DKA) in children.Aim: To characterise the presentation, treatment and clinical course of children with DKA complicated by severe ARF requiring renal support.Method: Retrospective notes review of patients aged <16 years admitted in 2011–2016 to 3 UK regional paediatric intensive care units (St George’s H...

ea0039oc8.4 | Oral Communications 8 | BSPED2015

Predictors of insulin resistance and the effect of Metformin treatment in obese paediatric patients

Gallen Hannah , Banerjee Indraneel , Clayton Peter E , Ehtisham Sarah , Padidela Raja , Patel Leena , Salsbury Louise , Skae Mars

Introduction: Paediatric obesity is a growing concern for the health service. There is currently no consensus for routine screening of metabolic profiles and medical treatment in obese paediatric patients.Aims/methods: We aimed to determine medium-term outcomes of Metformin treatment on BMI, glucose and insulin levels in obese paediatric patients. In a retrospective review, data were collected from obese paediatric patients on Metformin for insulin resis...

ea0039ep92 | Obesity | BSPED2015

Psychological sequelae in obese paediatric patients and predictors for weight loss

Gallen Hannah , Banerjee Indraneel , Clayton Peter E , Ehtisham Sarah , Nicholson Jacqueline , Padidela Raja , Patel Leena , Tobin Hannah , Skae Mars

Introduction: There is limited data on the psychological sequelae of obesity in paediatric patients.Aims/methods: We aimed to assess the prevalence of psychological comorbidities in obese paediatric patients. Internationally validated self-report questionnaires were offered to 19 patients and their parents from a tier three paediatric obesity clinics. These included the Paediatric Index of Emotional Distress (PI-ED); Beck Youth Inventory exploring self-p...

ea0036oc4.1 | Oral Communications 4 | BSPED2014

Utility of basal LH in comparison to the GnRH test for identifying central precocious puberty in girls

Shepherd Elizabeth , Patel Leena , Banerjee Indi , Clayton Peter , Ehtisham Sarah , Ivison Fiona , Padidela Raja , Skae Mars , Tetlow Lesley

Background: Harrington et al.1 suggest that basal LH of ≥0.3 IU/l as measured by ICMA (Immulite 2500) has 100% specificity and 90.5% sensitivity in identifying progressive central precocious puberty (CPP).Aims: To examine the utility of basal LH measured with the DELFIA assay for identifying CPP in girls.Methods: All girls under age 9 years (median 7.3 years) investigated for precocious puberty with a GnRH...

ea0033p4 | (1) | BSPED2013

Subnormal Synacthen testing in infants <6 months age: a review of diagnoses and outcomes

Tan Timothy Shao Ern , Chidanandaswamy Rajesh , Ivison Fiona , Skae Mars , Padidela Raja , Ehtisham Sarah , Clayton Peter , Banerjee Indi , Patel Leena

Background: The standard dose Synacthen test (SDST) is commonly used to identify glucocorticoid deficiency. A subnormal SDST in young infants raises the possibility of adrenal insufficiency (AI) due to pathology such as congenital adrenal hyperplasia (CAH). A physiological delay in maturation of adrenal glucocorticoid secretion may be another explanation especially in asymptomatic infants with a transiently subnormal SDST.Aims: To review the diagnoses an...

ea0033p7 | (1) | BSPED2013

Audit on the characteristics and management of patients in a large tertiary hospital paediatric adrenal clinic

Knox Ailie , Ehtisham Sarah , Clayton Peter , Jones Julie , O'Shea Elaine , Patel Leena , Skae Mars , Banerjee Indie , Padidela Raja

Adrenal insufficiency (Adr-I) and congenital adrenal hyperplasia (CAH) are important conditions requiring specialist attention and management. Recent CAH genotype–phenotype studies have linked mutations with enzyme functioning and disease severity. Accurate diagnosis for the cause of adrenal insufficiency and the genetic cause of CAH is vital as it impacts management and prognosis.Methods: We audited patients with Adr-I and CAH seen in outpatients f...

ea0030oc2.7 | Oral Communications 2 | BSPED2012

Growth, GH–IGF1 status and response to r-hGH therapy in 3-M syndrome, related to mutation status

Sakhinia Faezeh , Hanson Dan , Murray Philip , Kirk Jeremy , Cole Trevor , Skae Mars , Banerjee Indi , Padidela Raja , Patel Leena , Clayton Peter

Background: 3-M syndrome is associated with severe proportionate pre- and postnatal growth restriction, and is caused by mutations in CUL7, OBSL1, or CCDC8 genes.Aims and methods: To define baseline growth and GH–IGF1 axis status as well as response to r-hGH in relation to mutation status in 3-M children, using retrospective analysis of data from clinical notes.Results: 50 individuals (19 CUL7, 19 <...

ea0030p33 | (1) | BSPED2012

Karyotype-phenotype correlations in height and pubertal outcomes of Turners patients

Page Angela , O'Shea Elaine , Jones Julie , Banerjee Indi , Padidela Raja , Amin Rakesh , Skae Mars , Patel Leena , Clayton Peter , Ehtisham Sarah

Introduction: Turner syndrome (TS) is caused by the absence of all or some of the second sex chromosome. Consequences include short stature and ovarian failure. This study aimed to characterise karyotype-phenotype correlation in patients with TS.Methods: This was a retrospective audit of TS patients from the young person’s endocrine clinic (YPC). The karyotype, final height, pubertal progress and treatment were recorded for each patient and outcomes...

ea0030p58 | (1) | BSPED2012

Key efficacy issues in the use of recombinant human GH in children with prader–willi syndrome

Thornton Mary , Banerjee Indi , Padidela Raja , O'Shea Elaine , Jones Julie , Amin Rakesh , Patel Leena , Ehtisham Sarah , Clayton Peter , Skae Mars

Prader-Willi syndrome (PWS) is a rare genetic condition characterised by hypotonia, early feeding difficulties, hyperphagic obesity, hypogonadism and short stature; with an incidence between 1/15 000 and 1/25 000 live births in the UK. It is caused by failed expression of paternally inherited genes in the imprinting region of chromosome 15q11.2–q13. Recombinant human GH (rhGH) is the main pharmacological treatment used in PWS.Aims: We aimed to revie...

ea0023oc3.8 | Oral Communications 3 | BSPED2009

Determinants of remission and relapse in a cohort of children with thyrotoxicosis treated with dose titration of carbimazole

Banerjee Indi , Amin Rakesh , Okecha Elizabeth , Subbarayan Anbu , Skae Mars , Hall Catherine , Gleeson Helena , Ehtisham Sarah , Patel Leena , Clayton Peter

Introduction: Factors determining remission and relapse in children with thyrotoxicosis include ethnicity, age and thyroid hormone levels at diagnosis. We investigated if similar factors influence remission and relapse in a contemporary cohort of children with autoimmune thyrotoxicosis treated by dose titration of carbimazole.Methods: Forty-seven children (39 females) with thyrotoxicosis, treated with carbimazole, were followed up for ≥2 years. Ini...