Endocrine Abstracts

Aim and Objectives: Is Hashimoto thyroiditis (HT) different from thyroiditis with only antithyroglobulin antibodies (T-ATG)?Material and method: i). Diagnosis: ATPO >34 ui/ml = HT; ATPO normal with high ATG (>34 ui/ml) =T-ATG. ii). Thyroid function: TSH. iii). Patients: HT=1293, T-ATG=92. iv). Statistical analysis: Student tα, linear correlation tests....

Background: Adrenocortical oncocytoma is a veryrare adrenal tumor type, usually nonfunctioning and benign. Neurofibromatosistype 1 (NF1) is an autosomal dominant disease caused by mutations of the NF1 gene encoding neurofibromin, a tumor supressor gene that acts by activating a RAS GTP-ase which negatively regulates RAS activity. NF 1 is usually associated with pheocromocytoma, rarely with adrenal carcinoma, and no association with adrenal oncocytoma has been reported.<p c...

Introduction: Primary adrenal insufficiency (PAI) is a rare disease with a prevalence of 82–144 cases/milion. The etiology of PAI is represented primarily by autoimmune adrenalitis, followed by tuberculosis and less common by fungal infections, HIV, hemorrage in adrenal glands, certain drugs and by some genetic disorders such as Triple A syndrome (AAA), Adrenoleukodystrophy (ALD), congenital adrenal hypoplasia, congenital adrenal hyperplasia, etc.C...

Background: Hyperthyroidism is widely known to be an important cause of secondary osteoporosis through the accelerated rate of bone turnover, while primary hyperparathyroidism is typically associated with loss of cortical bone and less so of trabecular bone, as seen on dual-energy x-ray absorptiometry (DXA). The evaluation of bone quality in these categories is not fully understood and needs further research. The aim of this study was to compare the bone quantity and quality, ...

Introduction: Gastrinoma is rare gastrin-secreting neuroendocrine tumor (NET), usually located in the pancreas or duodenum. The most common presentations of gastrin secreting tumor is Zollinger-Ellison Syndrome (ZES). Only about 10% of patients have non demonstrable ulcer.Case presentation: A 67 years old female, with premature menopause, mild hypothyroidism with optimal replacement treatment, osteopenia and history of chronic gastritis, is admitted to o...

Introduction: Pituitary tumours may interfere with fertility and pregnancy may be uncommon in these cases, but some patients can conceive spontaneous. Also in pregnancy, due to the physiologic changes of the pituitary gland, gradual volume increase and cellular hyperplasia that target hormonal secretion, the evaluation of the pituitary function is very complex.Clinical cases: We present 5 cases of female patients (24 – 35 years old) that were diagn...

Introduction: Insulinoma is a rare tumor that causes spontaneous fasting hypoglycemia in a supposedly healthy adult. Mostly these tumors are single and benign, few are malignant and a minority is represented by multiple adenomas. The treatment of choice is surgical removal of the insulinoma, which cures the condition in the majority of cases. However, after performing the surgery, less than 10% of patients either develop diabetes mellitus or continue to have persistent hypogly...

Background: Primary hyperaldosteronism or Conn’s syndrome is one of the adrenocortical causes of hypertension, alongside hyperdeoxycorticosteronism, apparent mineralocorticoid excess and Cushing syndrome. The two types of hypertension-inducing adrenocortical syndromes (Conn’s and Cushing) are extremely rare to be decribed in the same patient. We describe a case of a patient with clinical and biochemical evidence of Conn’s syndrome due to a left adrenal adenom...

Introduction: Adrenal carcinomas are rare tumor. It has an estimated incidence of ~0.5–2 new cases per million people per year. Just 25% of adults with hormone-secreting adrenal carcinomas present overproduction of both glucocorticoids and androgens. Women develop adrenal carcinomas more often than men.Objectives: We report a case of 47-year-old female presented with weight gain, generalized weakness and hypertension for the last 6 months. Phy...

Introduction: Neuroendocrine tumors (NETs) are rare tumors that originate in cells from the neural crest, widely distributed in the body. Genitourinary (GU) NETs occurring in the bladder represent less than 1% of these primary malignancies. We present the case of a patient with two metachronous bladder tumors, of which one is NET.Case report: Male patient, 52–year-old, ex–smoker, known with hypertension, dyslipidemia and benign prostatic hype...