Searchable abstracts of presentations at key conferences in endocrinology

ea0081p44 | Calcium and Bone | ECE2022

Bone mineral density, trabecular bone score and vertebral fractures in acromegalic patients

Sorohan Madalina , Dobre Ramona , Baciu Ionela , Galoiu Simona , Dusceac Roxana , Niculescu Dan , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alka...

ea0081p688 | Pituitary and Neuroendocrinology | ECE2022

Implications of the 2017 WHO classification in the characterization of GH-secreting pituitary tumors

Burcea Iulia Florentina , Nicoleta Nastase Valeria , Raluca Ceausu Amalia , Dumitraşcu Anda , Maria Cimpean Anca , Raica Marius , Poiana Catalina

Introduction: Somatotroph pituitary adenomas (PAs) represent 10-15% of all resected PAs, exhibiting immunohistochemical (IHC) positivity for GH (growth hormone) and PIT-1 transcription factor (TF). The histopathological (HP) and IHC variability of each PA influences the phenotype, radiological features, and therapy response.Materials and methods: The study included 33 patients with acromegaly, with men: women ratio of 17:16. The HP-IHC characteristics we...

ea0081ep675 | Pituitary and Neuroendocrinology | ECE2022

Association between acromegaly and papillary thyroid cancer: A case series

Anne-Marie Stefan Andreea , Ioana Dumitriu Roxana , Iulia-Florentina Burcea , Raluca Trifănescu , Niculescu Dan Alexandru , Poiana Catalina

Background: Acromegaly is a rare disorder caused by hypersecretion of growth-hormone (GH) and insulin-like growth factor (IGF-1), the underlying lesion being most frequently a pituitary adenoma. This disease is associated with a higher risk of malignancy. We describe the clinical and biochemical particularities in a series of patients with acromegaly and papillary thyroid carcinoma (PTC).Case study: Out of 311 acromegalic patients, five cases that associ...

ea0081ep714 | Pituitary and Neuroendocrinology | ECE2022

Block and replacement therapy of a patient with Cushing’s disease and aggressive complications: a case report

Tănasie Denisa-Isabella , Simona Andreea Găloiu , Caragheorgheopol Andra , Corneci Cristina , Baloseanu Nicoleta , Poiana Catalina

Introduction: We describe a patient with CushingÂ’s disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

ea0081ep882 | Reproductive and Developmental Endocrinology | ECE2022

Anti-müllerian hormone analysis as a predictor of the polycystic ovary syndrome diagnosis in romanian women

Baculescu Nicoleta , Leonte Laura , Radian Serban , Gheorghiu Monica , Caragheorgheopol Andra , Biban Bianca , Serban Cristina , Grigorescu Florin , Poiana Catalina

Background: Higher anti-Müllerian hormone (AMH) values are associated with polycystic ovary syndrome (PCOS) and AMH is proposed as a marker of PCOS, however, the optimal diagnostic threshold is not yet defined.Aim: To study the significant correlations of AMH in PCOS and the accuracy and threshold of AMH for the PCOS diagnosis in Romania.Subjects and methods: Serum AMH, TT, LH, FSH, fasting glucose and insulin (Ins), HOMA-IR a...

ea0050p333 | Obesity and Metabolism | SFEBES2017

Genes involved in zinc homeostasis are associated with metabolic syndrome and insulin resistance in Romanian and French populations

Ilie Mirela Diana , Haydar Sara , Vintila Madalina , Lautier Corinne , Normand Christophe , Gheorghiu Monica , Poiana Catalina , Badiu Corin , Grigorescu Florin

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

ea0050p333 | Obesity and Metabolism | SFEBES2017

Genes involved in zinc homeostasis are associated with metabolic syndrome and insulin resistance in Romanian and French populations

Ilie Mirela Diana , Haydar Sara , Vintila Madalina , Lautier Corinne , Normand Christophe , Gheorghiu Monica , Poiana Catalina , Badiu Corin , Grigorescu Florin

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

ea0063p1133 | Reproductive Endocrinology 2 | ECE2019

Serum anti-Müllerian hormone is significantly associated with higher luteinizing hormone level in polycystic ovary syndrome

Baculescu Nicoleta , Leonte Laura , Radian Serban , Gheorghiu Monica , Muresan Andrei , Biban Bianca , Baleanu Maria , Grigorescu Florin , Poiana Catalina

Background: Recent data highlight the role of anti-Müllerian hormone (AMH) to trigger the neuroendocrine abnormalities involving GnRH and secretion of gonadotropins in polycystic ovary syndrome (PCOS).Aim: To study factors significantly correlated with neuroendocrine dysfunction in PCOS, with focus on AMH.Subjects and methods: We performed a cross-sectional study in 137 patients with PCOS selected by Rotterdam 2003 criteria an...

ea0049gp137 | Female Reproduction | ECE2017

Genetic susceptibility for adrenal hyperandrogenism in polycystic ovary syndrome

Baculescu Nicoleta , Haydar Sarah , Gheorghiu Monica Livia , Radian Serban , Lautier Corinne , Poiana Catalina , Pugeat Michel , Grigorescu Florin

Background: Hyperandrogenism is a main feature of the polycystic ovary syndrome (PCOS). Although its ovarian origin is well recognized, laboratory investigation suggested the contribution of adrenal gland, albeit of unknown mechanism.Aim: To understand the contribution of genetic factors in adrenal hyperandrogenism (AH) we investigated genome wide SNPs in subgroups of PCOS patients stratified as function of DHEAS levels in two ethnic populations (Romania...

ea0041gp21 | Adrenal (2) | ECE2016

Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours

Galoiu Simona , Pena Raluca , Trifanescu Raluca , Niculescu Dan Alexandru , Dumitrascu Anda , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...