Searchable abstracts of presentations at key conferences in endocrinology

ea0059ep14 | Adrenal and steroids | SFEBES2018

Cushing’s syndrome due to primary bilateral macronodular adrenal hyperplasia (PBMAH) - clinical and hormonal characterisation

Vladan Andreea , Radian Serban , Baranga Iuliana , Moraru Catalina , Deciu Diana , Dumitrascu Anda , Hortopan Dan , Iorgulescu Radu , Poiana Catalina

Background: PBMAH is a rare cause of adrenal Cushing’s syndrome, frequently due to aberrant adrenal expression of hormonal receptors.Aim: To describe 6 patients with PBMAH.Methods: Clinical, hormonal and imagistic evaluation.Results: Age at diagnosis of patients (4M/2F) was 50–79 years. One asymptomatic patient was incidentally diagnosed on abdominal CT, two patients had overt Cushing’s (centra...

ea0037ep86 | Adrenal cortex | ECE2015

Challenges in a the management of adrenal Cushing's syndrome associated with bilateral adrenal tumours and uterine leiomyoma

Poiana Catalina , Carsote Mara , Gruia Adriana , Peretianu Dan , Gheorghiu Ermina , Petris Rodica , Paun Sorin , Dumitrascu Anda , Hortopan Dan

Introduction: The Cushing’s syndrome associated bilateral adrenal tumours comprise a wide area of diagnosis; the therapeutic approach is challenging since unilateral intervention might involve persistent hypercotisolemia, and bilateral adrenalectomy induces chronic adrenal insufficiency. The adrenal vein catheterism is not available in many countries.Case report: 50-year old non-smoker female has the following medical history: 2 years ago she presen...

ea0037ep315 | Calcium and Vitamin D metabolism | ECE2015

The peripheral serotonin, the serum osteocalcin and CrossLaps: the assay in menopausal women

Carsote Mara , Capatina Cristina , Caragheorgheopol Andra , Peretianu Dan , Manda Dana , Baloescu Rene , Stefanescu Ana Maria , Paun Diana , Poiana Catalina

Introduction: 17th European Congress of Endocrinology 2015. The skeleton health is reflected by the turnover markers as serum CrossLaps (CL=bone resorption), and serum osteocalcin (OC=bone formation), and by the calcium metabolism parameters (as ionic blood calcium, and, probably, by the 24-h urinary calcium=24-h ca). The peripheral serotonin might have intra-normal levels in patients with osteoporosis but yet represents a part of the complex equation related to the bone homeo...

ea0037ep915 | Thyroid cancer | ECE2015

Graves' disease and papillary/insular thyroid cancer in a large compressive goitre

Carsote Mara , Dumitrascu Anda , Terzea Dana , Geleriu Andreea , Peretianu Dan , Alexandrescu Daniela , Chirita Corina , Iorgulescu Radu , Goldstein Andrei , Poiana Catalina

Introduction: The association between autoimmune thyroid disease and thyroid cancer is a dynamic field regarding the prevalence data and the common pathogenic background.Aim: We report a sixth decade women case with a 1 year history of Graves’ disease that was discovered with an aggressive differentiated thyroid carcinoma.Case report: M.E. 56-year-old female has a 10 months history of daily medium dose of thyamazolum which was...

ea0037ep1344 | Clinical Cases–Thyroid/Other | ECE2015

Endocrine assays in female patient with relapsing thymus cyst and myasthenia gravis

Carsote Mara , Terzea Dana , Baciu Ionela , Mihai Alexandra , Peretianu Dan , Vasilescu Florina , Popescu Mihaela , Trifanescu Raluca , Dumitrascu Anda , Poiana Catalina

Introduction: The congenital cystic neck masses underlie various diagnosis including tymic cysts. Even they are an embryological defects, the adult onset might be seen. The aetiology is not clearly established. The malignant behaviour or infections are correlated to the cysts. Aim: we present a female case with a complicated history of cysts.Case report: 42-year old female is known with the following medical history. Seven years ago she was operated for ...

ea0035p85 | Bone and Osteoporosis | ECE2014

The total fat mass and the fracture risk assessment: a study in 146 Romanian menopausal women

Carsote Mara , Radoi Valentin , Mihai Alexandra , Geleriu Andreea , Miulescu Rucsandra Danciulescu , Capatana Cristina , Trifanescu Raluca , Poiana Catalina

Introduction: The fat mass (FM) is assessed by DXA, magnetic resonance, etc. One of the most accessible methods for current practice is bioimpedance.Aim: We analyzed FM based on bioimpedance and fragility fracture risk.Material and method: This is a transversal study in women, admitted at C.I.Parhon National Institute of Endocrinology, Bucharest, Romania. The inclusion criteria were women in menopause. The exclusion criteria were p...

ea0035p941 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Determinants of survival in treated patients with acromegaly

Galoiu Simona , Suvoiala Andreea , Luca Aurelia , Ioacara Sorin , Purice Mariana , Baciu Ionela , Trifanescu Raluca , Coculescu Mihail , Poiana Catalina

Introduction: Patients with untreated acromegaly have a reduced survival, mostly due to vascular disease. Recent studies claim an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with reduced survival in acromegaly.Methods: Three hundred and twenty-seven patients (207 F/110 M, mean age 48.1±0.7 years, (range 18–81.42)) with acromegaly admitted in a sin...

ea0070aep94 | Adrenal and Cardiovascular Endocrinology | ECE2020

Results of biochemical testing in suspected primary hyperaldosteronism – a retrospective study

Vladan Andreea , Baranga Iuliana , Dumitrascu Anda , Hortopan Dan , Iorgulescu Radu , Jurcut Ruxandra , Zugravu Adrian , Poiana Catalina , Radian Serban

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of a series of hypertensive patients diagnosed with PA compared to those with negative biochemical screening (aldosterone-to-renin ratio/ARR)Methods: Clinical, hormonal and imaging evaluation.Results: We have screened for PA 34 patients diagnose...

ea0032p910 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Report of a new case of the novel AIP p.R314W mutation in a Romanian sporadic acromegaly patient

Baciu Ionela , Galoiu Simona , Capatina Cristina , Botusan Ileana , Dumitrascu Anda , Ciubotaru Vasilie , Coculescu Mihail , Poiana Catalina , Radian Serban

Introduction: We have recently described a novel AIP mutation c.940C>T, p.R314W, in a young sporadic acromegaly patient.Aim: To present a new case of AIP p.R314W mutation and screening results of a Romanian control group for p.R314W.Patients and methods: One sporadic acromegaly patient, investigated by sequencing screening of all six AIP exons, following informed consent, as part of a sporadic pituitary adenoma cohort. 110 cont...

ea0031p266 | Pituitary | SFEBES2013

Long-term results after treatment of craniopharyngioma: experience with 46 adult patients

Capatina Cristina , Preda Maria , Dumitrascu Anda , Hortopan Dan , Caragheorgheopol Andra , Alexandrescu Daniela , Ciubotaru Vasile , Coculescu Mihail , Poiana Catalina

Background: Craniopharyngioma is a rare, mostly benign tumor of the central nervous system, generally associated with important morbidity.Aim: To study the clinical characteristics and treatment outcome in adult patients.Methods:: Adult patients diagnosed with craniopharyngioma between 1980 and 2012, followed-up in the Pituitary and Neuroendocrine Department of the ‘C.I.Parhon’ National Institute of Endocrinology in Bucha...