Searchable abstracts of presentations at key conferences in endocrinology

ea0081p227 | Thyroid | ECE2022

Thyrotoxicosis-associated anemia at baseline and after methimazole treatment

Naglabeala Laura , Alexandru Niculescu Dan , Vladescu Anda , Poiana Catalina

Background: Overt newly diagnosed hyperthyroidism is frequently associated with mild anemia. However, there are limited data on long term evolution under methimazole treatment. Our aim was to study the baseline characteristics and evolution of anemia in the hyperthyroidism setting.Methods: We retrospectively assessed 58 consecutive patients [46 (79.3%) women] presenting with newly diagnosed overt thyrotoxicosis (43 Graves disease, 9 toxic nodular goiters...

ea0081ep729 | Pituitary and Neuroendocrinology | ECE2022

Case report: a challenging gastrinoma in a patient with renal cell carcinoma

Ioana Paduraru Alina , Burcea Iulia Florentina , Poiana Catalina

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

ea0065p105 | Bone and calcium | SFEBES2019

Complications at diagnosis in primary hyperparathyroidism

Capatina Cristina , Caragheorgheopol Andra , Voicu Gabriela , Poiana Catalina

Introduction: Primary hyperparathyroidism (PHPT) is associated with adverse effects especially on the bones and kidney. While nowadays it is mostly diagnosed at an asymptomatic stage, patients with overt involvement of the target organs at the time of diagnosis are still encountered.Aim: To explore the frequency of disease complications already present at the time of diagnosis in a cohort of patients with sporadic PHPT who meet the current surgical guide...

ea0067gp10 | Poster Presentations | EYES2019

Advanced metastatic sporadic medullary thyroid carcinoma: a case of thirty-year survival with progressive disease

Sorohan Madalina , Dusceac Roxana , Dumitrascu Anda , Poiana Catalina

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

ea0067gp28 | Poster Presentations | EYES2019

Case Report: Cushing disease developed from a nonfunctioning pituitary adenoma

Morea Alexandru , Lambrinoc Diana , Baciu Ionela , Poiana Catalina

Background: Only a few cases of pituitary tumor swift from non-functioning to Cushing disease (CD) have been previously presented in the literature. The exact mechanism is still unknown. We present a case of a patient with a non-functioning pituitary adenoma, who developed CD from the residual tumor, 13 years after the initial diagnosis and following 2 surgical interventions and radiation therapy.Case presentation: A 51-year-old woman initially presented...

ea0063p109 | Calcium and Bone 1 | ECE2019

Evaluation of bone quality in acromegaly and thyrotoxicosis using trabecular bone score

Sorohan Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Trabecular bone score (TBS) evaluates bone microarchitecture by measuring the grey-level variations from lumbar spine dual-energy X-ray absorbtiometry (DXA) images. Bone mineral density (BMD) in various endocrinopathies might not be sufficient in assessing bone fragility, especially in patients with acromegaly (ACM) but also in thyrotoxicosis. The aim of our study was to evaluate bone quality and quantity by BMD and TBS in patients with acromegaly and thyrotoxicosis.<p cla...

ea0063p277 | Pituitary and Neuroendocrinology 1 | ECE2019

Gross total versus incomplete resection of craniopharyngioma in adults

Capatina Cristina , Dumitrascu Anda , Caragheorgheopo Andra , Ciubotaru Vasilie , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the postsurgical evolution of craniopharyngioma in adults after total or incomplete surgical resection.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Buc...

ea0063p1065 | Pituitary and Neuroendocrinology 3 | ECE2019

Graves dermopathy associating toes lesion, pretibial myxedema and acropachy, rare, but aggressive extrathyroidal manifestation of Graves’ disease

Marinescu Mihai Constantin , Baciu Ionela , Alexandrescu Daniela , Poiana Catalina

Introduction: Graves’ dermopathy (also known as pretibial myxedema, thyroid dermopathy, Jadassohn-Dösseker disease or myxedema tuberosum) is a rare extrathyroidal manifestation of Graves’ disease, which is almost always associated with Graves’ ophthalmopathy. Although pretibial myxedema is the most frequent localization of Graves’ dermopathy, the involvement of toes with or without the involvement of pretibial area may occur.Obje...

ea0049ep911 | Neuroendocrinology | ECE2017

Increased morbidity associated with the treatment of craniopharyngioma

Capatina Cristina , Dumitrascu Anda , Caragheorgheopol Andra , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...

ea0049ep1067 | Pituitary - Clinical | ECE2017

Nonfunctioning pituitary incidentaloma – delayed onset of acromegaly and concomitant primary adrenocortical insufficiency

Radian Serban , Deciu Diana , Lefter Antonia , Poiana Catalina

Introduction: Pituitary incidentaloma (PitInc), defined as an unsuspected mass observed on imaging studies performed for unrelated conditions. Most such lesions are not clinically significant at initial evaluation and current guidelines recommend periodic follow-up.Aim: To present a rare case of delayed onset of acromegaly in a patient with a nonfunctioning PitInc, raising the question of the utility of prolonged follow-up of PitInc.<p class="abstext...