Searchable abstracts of presentations at key conferences in endocrinology

ea0056p84 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Metabolic and hormonal profile in primary aldosteronism as compared with essential hypertension

Trifanescu Raluca , Smarandoiu Alexandra , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

Background: Primary aldosteronism is associated with increased vascular mortality and morbidity.Aims: We aimed to assess metabolic and hormonal profile differences in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH).Patients and methods: Thirty-one patients (11 M/20 F) with primary aldosteronism, aged 46.2±12.9 years and 64 patients (24 M/40 F) with essential hypertension, aged 4...

ea0056p468 | Diabetes complications | ECE2018

Predictors for low bone mineral density assessed with DXA and trabecular bone score in patients with diabetes mellitus

Dragne Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Background: Diabetes mellitus is a metabolic disease associated with an increased risk of fracture, despite normal or increased bone mineral density (BMD), especially type 2 diabetes mellitus (T2DM). Trabecular bone score (TBS) is an imaging investigation that measures the grayscale variations on the lumbar spine performed on the DXA machine. The aim of this study was to evaluate the determinants associated with low BMD and TBS in patients with type 1 and type 2 diabetes melli...

ea0056p746 | Neuroendocrinology | ECE2018

Sox 2 expression in human pituitary adenomas-correlations with pituitary function

Capatina Cristina , Cimpeanu Anca , Raica Marius , Coculescu Mihail , Poiana Catalina

Introduction: Sox2 is a widely expressed marker of progenitor and stem cells in various organs, strongly expressed within Rathke’s pouch and the neural ectoderm. It exerts a critical role in the early stages of pituitary development but it is still expressed in the adult gland. Sox2 expression in pituitary adenomas and its possible correlation with clinicopathologic characteristics have not been investigated so far.Aim: To evaluate the immunohistoch...

ea0073aep541 | Pituitary and Neuroendocrinology | ECE2021

Successful recovery after COVID-19 infection in a patient with diabetes insipidus and pituitary insufficiency due to a pituitary stalk tumor

Trifanescu Raluca , Schipor Sorina , Vladoiu Suzana , Poiana Catalina

BackgroundFluid balance in patients with diabetes insipidus and COVID-19 is very fragile. The prevalence of hyponatraemia in patients with pneumonia due to COVID-19 seems to be low, but in patients admitted to intensive care units (ICU) is high (up to 20.5%). In contrast, hypernatraemia may also develop in COVID-19 patients in ICU (up to 3.7% of cases), due to insensible water losses from pyrexia, increased respiration rate and use of diuretics. Both hyp...

ea0073aep568 | Pituitary and Neuroendocrinology | ECE2021

Managing pituitary disease during COVID-19 pandemic: A case report

Dumitriu Roxana , Burcea Iulia Florentina , Dusceac Roxana , Poiana Catalina

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

ea0073ep127 | Endocrine-Related Cancer | ECE2021

Advanced metastatic disease in a low-grade pulmonary neuroendocrine tumor: a case report with partial response to targeted therapy

Cristiana Calin , Dusceac Roxana , Burcea Iulia-Florentina , Catalina Poiana

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

ea0086p254 | Neuroendocrinology and Pituitary | SFEBES2022

Prevalence of cancer in a cohort of acromegaly patients

Trifanescu Raluca , Toma Iustin , Dumitrascu Anda , Goldstein Andrei , Poiana Catalina

Background: Growth hormone directly stimulates tumour growth, angiogenesis and metastasis through autocrine and paracrine effects on cancer cells, while through IGF1 inhibits apoptosis and promotes epithelial proliferation. Although disputed, some studies have shown an increased cancer incidence in acromegaly patients, especially in uncontrolled subjects, while others have not.Aim: To assess prevalence of cancer in a cohort of patients with long term tre...

ea0086p259 | Neuroendocrinology and Pituitary | SFEBES2022

Successful use of recombinant human TSH prior to radioiodine therapy in an acromegaly patient with differentiated thyroid cancer and pituitary insufficiency

Toma Iustin , Trifanescu Raluca , Goldstein Andrei , Dumitrascu Anda , Poiana Catalina

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Standard treatment includes thyroidectomy (extention depending on tumour size, pathology and lymph nodes involvement). If indicated, radioiodine therapy after TSH stimulation either by levothyroxine withdrawal or rhTSH administration is recommended. In patients with thyrotropin deficiency rhTSH administration is mandatory.Case report: A 30-year-old woman, resident in...

ea0081p753 | Thyroid | ECE2022

Somatostatin analog therapy in advanced sporadic medullary thyroid carcinoma: a case report

Dumitriu Roxana , Cristiana Calin , Florentina Burcea Iulia , Dumitrascu Anda , Poiana Catalina

Introduction: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor derived from C cells that is responsible for approximately 5% of the gland malignancies, most of them occuring sporadically. Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic factor. Surgery is the only curative therapy while other chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostat...

ea0081p247 | Late-Breaking | ECE2022

Long-term mortality and excess mortality after hip fracture in the main urban area of Romania

Dobre Ramona , Ruzandra Poiana Ioana , Alexandru Niculescu Dan , Cirstoiu Catalin , Popescu Gheorghe , Poiana Catalina

Background: Excess mortality after hip fracture remains a problem of public health concern. Until present, for Romania no data is available regarding long term mortality rate and excess mortality after hip fracture. We aimed to evaluate the mortality rate 3 years after hip fracture and also standardized mortality rates of osteoporotic hip fracture in the capital city of Romania and suburban area.Methods: we collected data from over 98 % of fractures admi...