Searchable abstracts of presentations at key conferences in endocrinology

ea0038p324 | Pituitary | SFEBES2015

Metabolic state in ACTH insufficient and ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...

ea0037gp.21.04 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Exaggerated and additive ACTH responses following the combined ghrelin+CRH test in patients with Cushing's disease

Miljic Dragana , Polovina Snezana , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Petakov Milan , Popovic Vera , Micic Dragan

Ghrelin is able to stimulate HPA axis in both humans and animals. Exaggerated ACTH and cortisol responses to ghrelin have been shown in patients with CD. Here we studied the role of ghrelin alone or in combination with CRH in the diagnosis of CD. In 21 CD patient (18 female, age 49.8±10.2 years, BMI 29.8±0.8 kg/m2, ten macroadenomas 11 microadenomas) we performed: i) ghrelin test (100 μg iv bolus) ii) CRH test (100 μg iv bolus) and iii) ghrelin+C...

ea0037ep735 | Pituitary: clinical | ECE2015

Aetiology of hypopituitarism in adult life: last 10 years' experience in single centre database in Serbian population

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Popovic Vera , Petakov Milan

Hypopituitarism as deficiency of one or more anterior pituitary hormones, in adults can be consequence of acquired or genetic causes. Only few published studies investigated population-based aetiology of hypopituitarism. In the last 10 years new risks for hypopituitarism have been recognised (traumatic brain injury-TBI, subarachnoid haemorrhage, cranial irradiation).Aim: To present our experiences in the aetiology of hypopituitarism based on data collect...

ea0037ep764 | Pituitary: clinical | ECE2015

Pituitary adenoma in the elderly: a 10 years experience

Djurdjevic Sandra Pekic , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Pituitary adenoma (PA) is an under-investigated pathology in the elderly.Objective: To review our case records of patients >70 years with PA, in order to evaluate presentation symptoms, hormonal results, and pituitary morphology.Patients: 48 patients aged 70 years or older (21 females/27 males) were identified from the group of 610 patients with PA (7.9%) diagnosed at Neuroendocrine Unit, Clinic for Endocrinology, B...

ea0032p689 | Neuroendocrinology | ECE2013

Pituitary adenoma and associated tumors

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Popovic Vera

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

ea0032p695 | Neuroendocrinology | ECE2013

Des-acyl ghrelin acts directly and independently and counteracts acyl-ghrelin-induced neuronal activity in the central melanocortin system of rats

Stevanovic Darko , Delhanty Patric , Themmen Axel , Popovic Vera , Holstege Joan , van der Lely Aart-Jan

Ghrelin, the endogenous GH secretagogue, has an important role in metabolic homeostasis. It exists in two major molecular forms: acylated (AG) and des-acylated (DAG). Many studies suggest different roles for these two forms in energy balance regulation. In the present study, we compared the effects of acute intracerebroventricular (ICV) administration of AG, DAG and their combination (AG+DAG) to young adult Wistar rats on food intake and central melanocortin system modulation....

ea0032p859 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Genetic and clinical characteristics of Serbian FIPA families

Miljic Dragana , Pekic Sandra , Stojanovic Marko , Dzeranova Nadezhda , Denes Judit , Gabrovska Plamena , Korbonits Marta , Popovic Vera

Introduction: Recently, major advances have been made in genetics of familial acromegaly and isolated pituitary adenoma (FIPA). Mutations in the aryl hydrocarbon interacting protein (AIP) gene have been found in 25–50% of patients with FIPA and familial acromegaly.Aim of the study: Our goal was to identify and collect data on patients who met the criteria for FIPA.Patients and methods: The patients were identified between 2008...

ea0026p190 | Neuroendocrinology | ECE2011

The role of centrally applied ghrelin on hypothalamic AMPK activity and pituitary–adrenal responses in differently fed rats

Stevanovic Darko , Milosevic Verica , Nesic Dejan , Micic Dragan , Sumarac-Dumanovic Mirjana , Popovic Vera , Starcevic Vesna

The pandemic increase of obesity, malnutrition and associated comorbidities encouraged intensive studies on energy balance control. Ghrelin is a brain-gut orexigenic hormone that is involved in both the short-term and long-term regulation of energy homeostasis. The aim of this research was to investigate the role of centrally applied ghrelin on the pituitary morphofunctional features and corticosterone secretion in normal-fed, food-restricted and obese 8 weeks old Wistar male ...

ea0022p557 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Plasma ghrelin concentrations in narcoleptic patients

Lakocevic Milan , Petakov Milan , Rajsic Nenad , Macut Djuro , Antic Jadranka , Popovic Vera , Damjanovic Svetozar

Background: Narcolepsy is hypersomnia of central origin whose clinical features are excessive daytime sleepiness, hypnagogic hallutinations, sleep paralysis and cataplexy which comprises sudden transient loss of muscle tone often triggered by emotions. Narcolepsy with cataplexy is assiociated with hypocretin 1/orexin-A (HCRT 1/ORX-A) deficiency in central nervous system. Because of the link between ghrelin and HCRT 1/ORX-A wake-promoting effects there might be ghrelin deficien...

ea0022p563 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Influence of psychological variables on partially and fully recovering in patients with anorexia nervosa

Djurovic Marina , Arsic A , Pekic Sandra , Miljic Dragana , Doknic Mirjana , Petakov Milan , Stojanovic Marko , Popovic Vera

Introduction: Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. A product of complex interactions between psychological and clinical variables are important for the presence of the disease.Aim: The aim of the study was to investigate the variables which might predict full reproductive recovery of patients with anorexia nervosa.Material and methods: We studied closely mat...