Searchable abstracts of presentations at key conferences in endocrinology

ea0002p69 | Neuroendocrinology | SFE2001

Prenatal maternal nutrient restriction and regulation of the hypothalamo-pituitary-adrenal (HPA) axis in adult offspring

Matthews S , Lingas R

The prenatal environment has a major influence on development and function of endocrine systems throughout life. We have shown that a short period of maternal nutrient restriction (48h), at the time of maximal fetal brain growth in the guinea pig, permanently modifies HPA function throughout the life of the offspring. This effect is highly sex-specific; males exhibit decreased basal and activated pituitary-adrenal activity, while females exhibit elevated activity. In the prese...

ea0002p76 | Reproduction | SFE2001

Leptin and body fat: their roles in the control of reproductive activity in male Rhabdomys pumilio

Jackson C , Bernard R

Reproductive activity of male Rhabdomys pumilio is inhibited by exposure to a combination of reduced ambient temperature and food availability. However, the extent of this inhibition is reduced in mice that have maintained a body fat reserve. To determine if body fat stimulates reproduction via leptin, we treated 5 non-scrotal mice with exogenous leptin (40 micrograms subcutaneously twice per day for four days). A further 5 mice served as untreated controls. To determin...

ea0031p362 | Thyroid | SFEBES2013

Does closer monitoring of thyroid function post radioiodine reduce the severity of hypothyroidism when first detected?

Thida Myat , Ellis N R , Wright D , Peacey S R

We have previously shown that the current guidelines for monitoring thyroid function post radioiodine (RI), may not detect hypothyroidism until it has become severe, in a significant proportion of cases (J Endocrinol Invest 2012 35 82–86). An alternative more intense follow-up strategy was used whereby patients had TSH and FT4 measured at 4-week intervals post RI for 6 months. Endocrine specialist nurse-led telephone and nurse-led out-...

ea0026p357 | Steroid metabolism | ECE2011

Inhibitory effect of glucocorticoids on GLUT4 expression in visceral adipose tissue may be determined by increased 11β hydroxysteroid dehydrogenase 1 (11β-HSD1) expression

Mori R C T , Campello R S , Machado U F

Local glucocorticoids action depends on 11β hydroxysteroid dehydrogenase (11β-HSD) enzymes. Adipose tissues mainly express the 11β-HSD1, which activates inactive cortisone. Altered 11β-HSD1 and GLUT4 expressions have been reported in obesity. GLUT4 participates in the genesis and maintenance of insulin resistance/obesity, and could also be involved in the insulin resistant state observed in hypercortisolism. The aim of this study was to investigate the 11&#...

ea0026p683 | Diabetes therapy | ECE2011

Monitoring thyroid function in diabetic patients on treatment with glucagon-like peptide 1 analog

Danciulescu R , Musat M , Rosca R , Cristescu V , Poiana C

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

ea0024op1.5 | (1) | BSPED2010

Lack of ‘Hawthorn Effect’ in a diabetes pump clinic

Thompson R , Potts L , Agostini K , Viner R , Hindmarsh P

Clinical trials of multiple dose insulin (MDI) or pump therapy (CSII) suggest a short term effect with a waning of effect over time – the ‘Hawthorn Effect’. This may relate to interest in the patient during the trial or to lack of reinforcement of the education and training programme. We reviewed our experience in this area where we have used a structured education programme for CSII and MDI over the last 6–8 years and used Quality Control Theory to explore...

ea0024p4 | (1) | BSPED2010

Neonatal adrenal suppression from maternal steroid use: A retrospective case note study

Ho S , Petkar R , Avatapalle B , Coombs R

Introduction: Infants born to mothers on antenatal steroid medication may develop adrenal suppression postnatally which can be potentially life-threatening. However, the incidence is unknown and screening for at risk infants is not universal.Aim: The aim of our study was to review the outcome of infants born to mothers on antenatal steroids.Method: We retrospectively reviewed our neonatal “paediatric alerts” for mothers o...

ea0020p461 | Obesity and Metabolism | ECE2009

Diabetic patients with abnormal LFTS

Mlawa G , Bodmer C , D'Souza R , Skelly R

Objective: Patients with diabetes mellitus often have abnormal liver function tests without any symptoms. Our aim in this study was to evaluate the frequency and cause of abnormal LFTS in diabetic patients.Methods: 150 patients were enrolled from diabetic clinic who had been diagnosed with diabetes (creatinine,fasting glucose,random glucose, GTT were recorded). The following demographic data were recorded from each patients: age,sex, duration of diabetes...

ea0019p225 | Pituitary | SFEBES2009

Transient hypopituitarism following a viral illness

Kyaw Tun J , Jenkins R , D'Costa R , Nagi D

A 68-year-old previously well man was referred to the endocrinology department in April 2007 with generalised tiredness and dizziness following a recent viral upper respiratory illness. He had no symptoms to suggest pituitary dysfunction. He was normotensive and lacked clinical features of hypopituitarism or dysthyroidism. Visual fields were normal to confrontation. Testicular volumes were normal. Initial baseline pituitary function tests (reference ranges in brackets): FT<sub...

ea0019p346 | Thyroid | SFEBES2009

Graves’ thyrotoxicosis in a patient with previous thyroid lymphoma and thyroid adenoma

Tun J Kyaw , Jenkins R , Nagi D , D'Costa R

A 62-year-old woman was referred to the endocrine clinic with new onset thyrotoxicosis. She had previously had two other conditions affecting her thyroid gland. In 1977, she underwent a right thyroid lobectomy for a non-functioning thyroid adenoma. In 2002, she presented with a rapidly enlarging left sided goitre, which proved to be thyroid B-cell lymphoma on core biopsy. She was treated with chemotherapy alone and remains under regular haematology follow up. Serial thyroid fu...