Endocrine Abstracts

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

65 yr female presented with headaches, heat intolerance and loose stools. She had cerebrovascular accident, osteoporosis and vitiligo. A 24 hr ECG revealed atrial flutter with heart rate upto 117 beats /minute. Her medications include warfarin and bisoprolol.A Thyroid function test (TFT) revealed Free T4 (Ft4): 32 pmol/L (9-19) Free T3: 7.97 pmol/L (3.6–6.5), TSH: 5.7 mU/L (0.35–4.94). Other anterior pituitary function tests were ...

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

65 yr female presented with headaches, heat intolerance and loose stools. She had cerebrovascular accident, osteoporosis and vitiligo. A 24 hr ECG revealed atrial flutter with heart rate upto 117 beats /minute. Her medications include warfarin and bisoprolol.A Thyroid function test (TFT) revealed Free T4 (Ft4): 32 pmol/L (9-19) Free T3: 7.97 pmol/L (3.6–6.5), TSH: 5.7 mU/L (0.35–4.94). Other anterior pituitary function tests were ...

Background: Bilateral neck exploration (BNE) as a routine surgery for PHPT is favored by many experts in endocrine surgery as it may provide the identification of preoperatively undetected multiglandular disease. But for a large cohort of patients BNE remains unnecessary and its possible higher rate of surgical complications is being widely discussed.Objectives: The aim of the study was to evaluate the complication rates of bilateral neck exploration in ...

Case history: A 59-year-old lady with a background of type 2 diabetes, hypercholesterolemia and hypertension presented with a 3-week history of progressively worsening central abdominal pain and vomiting. Her drug history included bezafibrate and atorvastatin on which she was unable to meet her cholesterol and lipid targets and hence were stopped two weeks prior to her admission. The plan had been to start once fortnightly Alirocumab, a PCSK9 inhibitor; which had been delayed ...

A 70 year old female was referred with a putative diagnosis of phaeochromocytoma. She was awaiting hiatus hernia surgery; the diagnosis was based on a history of hypertension and a persistent sinus tachycardia of 110 bpm. Investigations had shown modest elevation of 24 hour normetadrenaline at 4.71 to 4.98 micromol/24 hr (<4.4) on 3 occasions and plasma normetadrenaline of 2398 and 2504 pmol/l (<1180). Review of her medical records confirmed that the onset of tachycard...

A 25-year-old woman with hypertension was referred with 12 months history of watery right eye and slowly growing swelling in the lateral wall of the right orbit. On examination there was proptosis with superior and medial displacement of the right globe. CT scan of facial bones revealed a 3.5 cm swelling with internal cortical scalloping and calcification arising from the zygoma within the right lateral orbital wall. Further lucent lesions were identified in the frontal bone, ...

We present a case of a 50 year old patient with sepsis and a significant and symptomatic hypercalcaemia of 3.38 mmol/l with a background of MS. The infection responded to treatment however the hypercalcaemia persisted despite appropriate measures. Further investigation showed a suppressed PTH, normal ACE level, electrophoresis and 25(OH) vitamin D level, but found her to be thyrotoxic with TSH suppressed at <0.01, free T4 – 37.2 nmol/l, free T3 – 212 nmol/l. She ...

Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic disturbances such as changes in lipid profile, diabetes, hypertension and metabolic syndrome. Variants on vitamin D receptor (VDR) gene have also been related to metabolic comorbidities in general population. Therefore, the aim of the present study was to investigate whether Apa-I polymorphism (rs7974232) in the VDR gene is associated with metabolic syndrome and endocrine profile in PCOS. In this c...