Searchable abstracts of presentations at key conferences in endocrinology

ea0003s37 | New Treatments for Osteoporosis | BES2002

Prospects for new treatment approaches in osteoporosis

Russell R

There have been remarkable recent advances in bringing osteoporosis to public attention, in understanding its pathogenesis, and in improving its diagnosis and treatment.The challenges in the next decade will include the problem of delivering the benefits of this knowledge to as many patients as possible in an efficient and cost-effective manner.Up until now, all the major drugs used to prevent or treat osteoporosis are inhibitors...

ea0003s38 | New Treatments for Osteoporosis | BES2002

Parathyroid hormone for osteoporosis treatment

Lindsay R

Parathyroid hormone (PTH) is a novel treatment for osteoporosis, that stimulates bone formation and turnover, unlike current treatments that are antiresorptive in their actions. Both the entire molecule (1-84hPTH) and the amino-terminus of the molecule (1-34hPTH) are being studied in clinical trials. In 8 recent clinical trials (two involving males with osteoporosis) PTH has been shown to produce larger increments in vertebral bone mass than any currently available agent. In s...

ea0002sp5 | (1) | SFE2001

The endocrinology of renal vitamin D metabolism

Bland R

The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is vital for calcium/phosphate homeostasis, bone cell differentiation and modification of immune responses. Synthesis of 1,25D3 is catalysed by the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D3-1α-hydroxylase (1α-OHase; CYP27B1). Although 1α-OHase has been detected at several extra-renal sites, circulating levels of 1,25D3 appear...

ea0019p327 | Steroids | SFEBES2009

Measuring cortisone production in man using a new stable isotope tracer

Hughes K A , Reynolds R M , Andrew R , Walker B R

Background: 11β-hydroxysteroid dehydrogenases (11β-HSD1&2) interconvert cortisol (F) and cortisone (E). Although 11β-HSD1 reductase activity has been measured in vivo, E production (dehydrogenase activity) has not been quantified using a Gold Standard technique, steady state tracer infusion.Aim: To develop a method to measure E production in vivo using the stable isotope tracer d2-cortisone (d2E).Me...

ea0029oc16.6 | Female Reproduction Clinical | ICEECE2012

Kisspeptin-10 stimulation of gonadotropin secretion in women is modulated by sex steroid feedback

George J. , Anderson R. , Millar R.

Background: Sex-steroid feedback regulates gonadotropin (LH and FSH) secretion. Kisspeptin, a novel hypothalamic neuropeptide, stimulates gonadotropin secretion by stimulating GnRH secretion, and has been shown in animal models to play a central role in mediating sex steroid feedback.Hypothesis: As estrogen feedback occurs at both the hypothalamus and the pituitary in women, we hypothesized that the stimulatory effect of kisspeptin-10 would be dependent ...

ea0029p456 | Clinical case reports - Thyroid/Others | ICEECE2012

Insulinoma presenting as post-prandial hypoglycaemia

Sriraman R. , Said R. , Jagger C.

A 52 year old lady with hypothyroidism and hypertension was referred by her GP for unexplained low blood glucose on several occasions. There was history of vacant spells with confusion and disorientation over the previous year. When referred for neurological assessment, no abnormality was identified. Her medications included amlodipine 5 mg, ramipril 10 mg, thyroxine 50 mcg, loratidine 10 mg. Her BMI was 44 kg/m2.Additional investigations arra...

ea0029p738 | Diabetes | ICEECE2012

Telemedicine and Type 1 diabetes: A pilot project

Arrais R. , Diniz J. , Valentim R.

Type 1 diabetes is among the top rising problems in public health, since its incidence is growing in almost all series studied, all over the world. The gold standard for its control is based on achieving good metabolic control, through insulin, diet and regular physical activities, and it is delivered by a multiprofessional team in tertiary centers, which have enough resources (material and personnel). Scheduled visits are ideally programmed three to four times annually, but m...

ea0029p1619 | Thyroid (non-cancer) | ICEECE2012

Assessment of cognitive function in hypothyroidism using P300 evoked potentials

Sahay R. , Reddy R. , Pallagolu S.

The P300 wave is an event related potential which is used to assess cognitive function, it is recorded as positive deflection in voltage at latency of roughly 300 ms. P300 latency suggests that shorter latency times are related to cognitive performance. This study was undertaken to evaluate objectively effect of hypothyroidism on latencies of ERPs and response to thyroxine replacement.Biochemically proven new onset cases with hypothyroidism were enrolled...