Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep86 | Adrenal and Cardiovascular Endocrinology | ECE2020

VDR-GR complex reduces apoptosis in acute myeloid leukemia cells via reduction of GR transcriptional activity

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Kalotychou Vasiliki , Lembesis Panayiotis , Randeva Harpal , Papavassiliou Athanasios G , Kassi Evanthia

Introduction: Glucocroticoids (GCs) which are routinely used in the treatment of Acute Lymphocytic Leukemia (ALL), found recently to be beneficial in a subset of AML patients resistant to chemotherapy, by promoting leukemia cells apoptosis. Current studies indicate that vitamin D (VitD) deficiency is highly prevalent among AML patients, posing vitamin D as a therapeutic supplementation. Our previous study demonstrated that VitD exerts inhibitory effect on Dexamethasone-induced...

ea0031p126 | Clinical practice/governance and case reports | SFEBES2013

Title: A case of primary hypoadrenalism secondary to amyloidosis

Watkins John , Verran Alice , Aftab Saboor , Randeva Harpal , Barber Tom , Reddy Narendra

Introduction: Endocrinopathy is frequently seen in systemic amyloidosis and commonly involves thyroid and gonads. We report a case of primary adrenal failure secondary to systemic light chain amyloidosis (AL), involving kidney, liver, spleen, gut, nerves and tongue.Case: A 42-year-old Somalian lady presented with 2-year history of lethargy, febrile episodes and 21 kg weight loss. Investigations showed increase in serum lambda light chain 103 mg/l (5.7&#1...

ea0028p167 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

The Hepatokine Fetuin-A is increased in PCOS women. Association with metabolic syndrome and regulation by metformin

Aghilla Mohamed , Adya Raghu , Tan Bee , Lehnert Hendrik , Ashawesh Khaled , Randeva Harpal

Introduction: Polycystic Ovary Syndrome (PCOS) is associated with insulin resistance, visceral obesity -metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD). Fetuin-A, human protein: α2-Heremans-Schmid glycoprotein is an abundant serum protein exclusively expressed in the liver and has been suggested to act as a link between obesity, insulin resistance (IR), and MS.Aims: A) To determine levels of Fetuin-A in PCOS women. B) To invest...

ea0021p93 | Clinical practice/governance and case reports | SFEBES2009

Reasons for treatment changes in hypogonadal men undergoing testosterone replacement

Dutton David , Outterside Kate , Padinjakara Rayin , Weickert Martin , Randeva Harpal , Sankar Sailesh

Aims: Treatment regimes for low testosterone are well established but reasons for treatment change and patient preferences are less well known. We looked at the type of testosterone replacement, subsequent modification of replacement and reason for that change.Methods: Data were collected from the electronic case notes of 50 patients on testosterone replacement for at least 6 months attending endocrine clinics in a University Teaching Hospital.<p cla...

ea0021p132 | Diabetes and metabolism | SFEBES2009

Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices

Lewandowski Krzysztof , Cypryk Katarzyna , Nadel Iwona , Lewinski Andrzej , Bienkiewicz Malgorzata , Tan Bee , Randeva Harpal

Background: Gestational diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. In our study we have endeavoured to assess serum levels of insulin-sensitising omentin and pro-inflammatory thrombospondin-1 (TSP-1) in GDM.Subjects and methods: The study included 20 women with GDM, diagnosed according to the WHO criteria, age 29.7±5.5 (mean±S.D.), BMI...

ea0021p153 | Diabetes and metabolism | SFEBES2009

A role for aquaglyceroporins in adipogenesis

Brown James , Conner Matthew , Bill Roslyn , Ramanjaneya Manjunath , Bailey Clifford , Randeva Harpal , Conner Alex

Aims/objectives: Glycerol cycling plays an essential regulatory role in metabolism in both health and disease. Aquaporins (AQPs) are a recently described family of water transporting membrane proteins, which contain a subset of members that also have the ability to transport glycerol across the cell membrane. This study sought to investigate the adipose tissue expression profile of AQPs in humans, and to assess the role of AQPs in adipocyte differentiation.<p class="abstex...

ea0019oc7 | Young Endocrinologist prize session | SFEBES2009

In vivo and ex vivo regulation of Visfatin production by leptin in human and murine adipose tissue: role of the PI3K and MAPK pathways

Tan Bee , Chen Jing , Brown James , Adya Raghu , Ramanjaneya Manjunath , Bailey Cliff , Lehnert Hendrik , Randeva Harpal

Apart from its role in energy storage, adipose tissue produces several hormones and cytokines termed ‘adipokines’ that have wide-ranging effects on carbohydrate and lipid metabolism; and thereby, play an important role in the pathogenesis of the metabolic syndrome. Visfatin is a novel adipokine, levels of which increase in obesity and is adipogenic; properties common to that of leptin. Thus, leptin may modulate visfatin production in adipose tissue. We investigated t...

ea0019p131 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Identification of nesfatin-1/NUCB2 as a novel depot-specific adipokine in human and murine adipose tissue: aletered levels in obesity and food deprivation

Ramanjaneya Manjunath , Chen Jing , Brown James , Patel Suketu , Tan Bee , Randeva Harpal

NESFATIN-1 is a recently identified hypothalamic satiety molecule derived from its precursor protein, NEFA/nucleobindin2 (NUCB2). Although the hypothalamus is considered the cornerstone for maintenance of energy homeostasis, adipose tissue plays an important role in the integration of metabolic activity and energy balance; communicating with peripheral organs and the brain via secreted proteins, termed adipokines. Many hypothalamic satiety regulatory peptides have been describ...

ea0019p146 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Metformin decreases angiogenesis via ERK1/2/ERK5 pathways by increasing the anti-angiogenic adipokine thrombospondin-1

Tan Bee , Kumar S Prashanth , Chen Jing , Heutling Dennis , Mitchell Dan , Lehnert Hendrik , Randeva Harpal

Aims: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiovascular complications. Thrombospondin-1 (TSP-1) is a novel anti-angiogenic adipokine highly expressed in obese, insulin-resistant subjects. We sought to assess TSP-1 levels in adipose (AT) from PCOS women and matched controls. The effects of metformin treatment on circulating TSP-1 levels in PCOS subjects; effects of serum from normal and PCOS women on in vitro migration and...

ea0016p500 | Obesity | ECE2008

Retinol-binding protein 4 (RBP-4) levels do not change after oral glucose tolerance test in obese and overweight individuals, but correlate with some indices of insulin resistance

Lewandowski Krzysztof C , Basinska-Lewandowska Magdalena , Bienkiewicz Malgorzata , Randeva Harpal S , Lewinski Andrzej

Background: Secretory products from adipocytes may contribute to increased insulin resistance (IR). Retinol-binding protein-4 (RBP-4) may increase IR in mice, with elevated levels in insulin resistant mice and humans with obesity and type 2 diabetes. Mechanisms regulating RBP-4 synthesis remain not fully understood. It is not clear whether short-term hyperglycaemia alters RBP-4 levels in humans. In order to investigate this, we measured serum RBP-4 concentrations during 75 gra...