Searchable abstracts of presentations at key conferences in endocrinology

ea0016p534 | Obesity | ECE2008

Insulin and glucose regulates omentin-1, a novel adipokine: relation to women with the polycyastic ovary synfrome

Tan Bee K , Adya Raghu , Farhatullah S , Lewandowski KC , O'Hare Paul , Lehnert Hendrik , Randeva Harpal S

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exists on the relative expression and regulation of omentin-1 in adipose tissue (AT) of PCOS women.Objectives: To assess mRNA and protein levels of omentin-1 in omental (om) AT of PCOS women and matched controls, including circulating omentin-1. Ex vivo and in vivo</...

ea0016p657 | Signal transduction | ECE2008

Orexins stimulate steroidogenic acute regulatory (StAR) protein expression through multiple signalling pathways

Ramanjaneya Manjunath , Conner Alex , Chen Jing , Lehnert Hendrik , Stanfield Peter , Randeva Harpal

Orexins mediate a variety of physiological processes including feeding behaviour, the circadian pathway and cortisol secretion. Steroidogenesis is regulated by a variety of neuropeptides and one of the key rate-limiting steps is cholesterol transport across the mitochondrial membrane by the steroidogenic acute regulatory (StAR) protein. StAR expression can be regulated through several different signalling pathways. Despite the clear link between orexins and steroid production,...

ea0014p71 | (1) | ECE2007

Raised serum, adipocyte and adipose tissue retinol binding protein 4 (RBP4) in women with polycystic ovary syndrome

Tan Bee Kang , Chen Jing , Pua Sheryl , Richard Kennedy C , Randeva Harpal S

Context: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and obesity, both predisposing factors to type 2 diabetes. A very recently described adipokine, retinol-binding protein 4 (RBP-4), has been shown to modulate insulin signalling and possibly lead to IR. At present, there is no data that depict the relative expression of RBP-4 in either serum or adipose tissue of PCOS women.Objectives: In women with PCOS compared to matche...

ea0014p240 | (1) | ECE2007

Identification of orexin receptors in brown adipocytes: functional effects of orexin-B

Digby Janet , Chen Jing , Markovic Danijela , Viengchareun Say , Lombes Marc , Lehnert Hendrik , Randeva Harpal

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

ea0013p174 | Diabetes, metabolism and cardiovascular | SFEBES2007

Identification of orexin receptors in brown adipocytes: functional effects of orexin-B

Digby Janet , Chen Jing , Markovic Danijela , Viengchareun Say , Lombes Marc , Lehnert Hendrik , Randeva Harpal

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

ea0013p264 | Reproduction | SFEBES2007

Retinol binding protein 4 suppresses during normal pregnancy – an inverse relationship with insulin resistance

Pierides Michael , Lewandowski Krzysztof , Bennet Jeanette , Dunlop Diane , Randeva Harpal , O’Hare Paul

Retinol binding protein-4 (RBP4) is an adipokine reportedly linked to physiological states of insulin resistance and impaired glycaemia. Pregnancy is a physiological state characterised by changes in carbohydrate metabolism and increased insulin resistance. Our aim was to determine plasma levels of RBP4 during early pregnancy, late pregnancy and postpartum in normal women.Fasting plasma levels of RBP4, insulin and glucose were collected and assayed (ELIS...

ea0073yi7 | Young Investigator Awards | ECE2021

Alterations in clock genes expression in eutopic and ectopic endometrial tissue

Karapanagioti Angeliki , Narjes Nasiri-Ansari , Mavrogianni Despoina , Randeva Harpal , Papavassiliou Athanasios G. , Drakakis Peter , Kassi Evanthia

IntroductionEndometriosis is a dysplastic disease affecting approximately 7–10% of reproductive–aged women. It is defined as the presence of endometrial-like tissue outside the uterine cavity. Disruption of circadian rhythm in night shift worker has been associated with menstrual irregularity and increased chance of developing endometriosis and ovarian tumors. The central circadian clock system located in hypothalamic suprachiasmatic nucleus (...

ea0075m12 | Metabolic Bone | EYES2021

Management considerations for adults with x-linked hypophosphatemia: A case report

Thadani Puja , Khan Uzma , Murthy Narasimha , Rao Ranganatha , Sankar Sailesh , Randeva Harpal

Background: X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive musculoskeletal disorder. Prompt diagnosis and treatment in childhood ensures adequate bone matrix mineralization and skeletal growth. There is no consensus on indications for treatment in adult patients.Case Presentation: A 25 year old female was referred to endocrinology with a right ankle fragility fracture. She was known to have XLH, diagnosed in Poland at the age of 1 yea...

ea0075p07 | Pituitary and neuroendocrinology | EYES2021

Pregnancy and diabetes insipidus – A management conundrum

Thadani Puja , Khan Uzma , Giovos Georgios , Smith Megan , Dhingra Vandana , Shad Amjad , Randeva Harpal , Machenahalli Pratibha

Background: Diabetes Insipidus (DI) is uncommon during pregnancy. It may predate pregnancy, be unmasked by pregnancy or arise de novo during pregnancy secondary to other pathology. We present a case of DI in pregnancy to highlight challenges in management.Case Report: A 27-year-old lady at 21 weeks’ gestation, presented to A&E with worsening headache and confusion for three to five months. She was hemodynamically stable, had bitemporal hemianopi...

ea0075p09 | Pituitary and neuroendocrinology | EYES2021

Case Report: Pituitary metastasis and its diagnostic complexity

Chaudhury Nadia , Thadani Puja , Awala Orighomisan , Randeva Harpal , Correa Peter , Machenahalli Pratibha , Gholap Nitin

Background: Pituitary metastasis (PM) is a rare occurrence in malignancy, associated with poor prognosis. Only 7% of patients are symptomatic. High index of suspicion and prompt investigation are essential. We report a case of PM, highlighting challenges in diagnosis and management.Case Report: Sixty-six year old male was referred to endocrinology due to headaches and hyponatremia. He had metastatic colorectal carcinoma, treated with bowel, liver and lun...