Searchable abstracts of presentations at key conferences in endocrinology

ea0050p339 | Obesity and Metabolism | SFEBES2017

The Prevalence of Obstructive Sleep Apnoea in women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

Kahal Hassan , Kyrou Ioannis , Uthman Olalekan , Brown Anna , Johnson Samantha , Wall Peter , Metcalfe Andrew , Tahrani Abd , Randeva Harpal

Background: Obesity is a common risk factor for obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS).Objective: To examine the prevalence of OSA in women with PCOS.Search sources: Electronic databases [Medline, Embase, Cinahl, PsycInfo, Scopus, Web of Science, Opengrey, and Cochrane Central Register of Controlled Trials], conference abstracts, and reference lists of relevant articles. The...

ea0050ep061 | Neoplasia, Cancer and Late Effects | SFEBES2017

Hypertestosteronemia and primary infertility from a mediastinal extragonadal germ cell tumor

Dimitriadis Georgios K , Mytilinaiou Maria , Davasgaium Allan , Sambrook Diane , Drakou Eftychia E , Hewins Claire , Nalawade Nilisha , Randeva Harpal S

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >...

ea0069oc2 | Oral Communications | SFENCC2020

Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour

Onyema Michael , Drakou Eftychia , Giovos Georgios , Leca Bianca , Ganguly Ratnadeep , Murthy Narasimha , Grossman Ashley , Randeva Harpal , Dimitriadis Georgios

Case history: Herein, we report the case of a 79-year-old male who presented acutely to A&E with recurrent episodes of symptomatic hypoglycaemia. A random glucose at presentation was low at 1.4 mmol/l and upon correction symptoms resolved. While hospitalized, he continued having episodes of symptomatic hypoglycaemia, requiring treatment with intravenous dextrose and per os steroids. Once stable, he was discharged with advice.Investigations: ...

ea0065p358 | Reproductive Endocrinology and Biology | SFEBES2019

Effects of the endocrine disrupting chemical bisphenol A (BPA) in human placentation in vitro

Greca Sophie-Christine de Aguiar , Kyrou Ioannis , Pink Ryan , Randeva Harpal , Grammatopoulos Dimitris , Silva Elisabete , Karteris Emmanouil

Endocrine disrupting chemicals (EDCs) are environmental chemicals/toxicants that humans and wildlife are exposed to and which interfere with the action of hormones. Bisphenol A (BPA) is classified as an EDC with xenoestrogenic activity and is recognized by the WHO as a chemical with potentially potent effects on humans throughout different phases of development. A significant knowledge gap still exists regarding the complete spectrum of BPA-induced effects on human physiology,...

ea0063p1025 | Interdisciplinary Endocrinology 2 | ECE2019

In vitro study of Orexin alpha effects on factors involved in atherosclerosis: a dual role?

Karapanagioti Angeliki , Spenzta Flora , Dimitriadis Georgios K. , Nasiri-Ansari Narjes , Lianidou Evi , Papavassiliou Athanasios G , Randeva Harpal S , Kassi Eva

Introduction: Malnutrition in neonates and children has been associated with adult-onset diseases such as obesity and atherosclerosis. Infants breastfeeding exhibit a different pattern of orexin-α secretion compared to formula-fed or infants on parenteral feeding. Given the protective role of maternal milk in the onset of metabolic syndrome and atherosclerosis in later life, we hypothesized that orexin-α may be involved in this process. We studied in vitro t...

ea0044p193 | Obesity and Metabolism | SFEBES2016

Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes

Jackisch Laura , de la Escalera Lucia Martinez , Murphy Alice , Al-Daghri Nasser , McTernan Philip , Randeva Harpal , Tripathi Gyanendra

Background: The pathogenesis of obesity and T2DM mediates mitochondrial dysfunction which, in part, may arise as a consequence of endoplasmic reticulum (ER) stress. However, the potential impact of ER stress on mitochondria dysfunction is unclear. Therefore, we investigated whether induction of ER stress contributes to mitochondrial dysfunction in human adipocytes using 1) human differentiated adipocyte cell line (Chub-S7, n=12); and 2) primary differentiated lean and...

ea0059p134 | Neuroendocrinology and pituitary | SFEBES2018

Prolactin as a surrogate marker of prolactinoma diagnosis in PCOS

Dimitriadis Georgios K , Kyritsi Eleni Magdalini , Angelousi Anna , Mehta Hiten , Shad Amjad , Mytilinaiou Maria , Kaltsas Gregory , Randeva Harpal S

Background: To identify a serum prolactin (PRL) cut-off value indicative of a PRL-producing adenoma in women with polycystic ovarian syndrome (PCOS) and hyperprolactinaemia and characterize such patients. Materials and methods: In the present retrospective case–control study, the medical records of 528 PCOS women were reviewed. Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94.0 ng/ml and/or symptoms suspicious of a pituit...

ea0059p162 | Obesity & metabolism | SFEBES2018

The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: a cross-sectional study

Kahal Hassan , Tahrani Abd , Kyrou Ioannis , Dimitriadis Georgios , Kimani Peter , Barber Thomas , Nicholls Matthew , Ali Asad , Weickert Martin , Randeva Harpal

Background: Obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS) are associated with significant comorbidities and commonly coexist. The primary aim of this study was to examine the relationship between OSA and quality of life (QoL) in women with PCOS.Study design: Observational cross-sectional study.Methods: Women with PCOS were recruited from a single secondary care centre in the UK. PCOS was diagnosed according to...

ea0031p77 | Clinical practice/governance and case reports | SFEBES2013

A case of dry beriberi following bariatric surgery

Verran Alice , Watkins John , Reddy Narendra , Barber Tom , Piya Milan , Randeva Harpal , Kumar Sudhesh , Aftab Saboor , Sankar Sailesh

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...

ea0031p221 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Brown adipose tissue identification in an adult human using IDEAL MRI

Reddy Narendra , Jones Terence , Wayte Sarah , Adesanya Oludolapo , Yeo Yen , Randeva Harpal , Kumar Sudhesh , Hutchinson Charles , Barber Tom

Aim: Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance imaging (MRI) based method to identify human BAT and delineate it from white adipose tissue (WAT), and validate it by providing immunohistochemical confirmation.Methods: Initial scanning with 18F-FDG PET–CT radiotracer uptake on a 25-year-old Caucasian female wit...