Endocrine Abstracts

Background and aimsSeveral factors that worsen the prognosis of the new coronavirus SARS-CoV-2 have been identified, such as obesity or diabetes. However, despite that nutrition may change in a lockdown situation, little is known about the influence of malnutrition among subjects hospitalized due to COVID-19. Our study aimed to assess whether the presence of malnutrition among patients admitted due to COVID-19 had any impact on clinical outcomes compared...

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

Aim: Atherosclerotic cardiovascular disease, defined as myocardial infarction (MI), cerebrovascular accident (CVA), peripheral artery disease (PAD), is the main cause of morbidity and mortality in people with diabetes mellitus (DM) and the main cause of health expenditure in these patients.Like in other parts of the world, a prospective study of the Asturian population showed that the mortality risk due to cardiovascular diseases was significantly higher...

RET is a tyrosine kinase receptor activated by GDNF, NTN, ART and PSPN through GFRa1,2, 3 and 4 respectively. Activation of the receptor elicits intracellular pathways such us Ras/MAPK and PI3K/AKT leading to differentiation and proliferation. Our group has previously shown that RET is expressed specifically in the somatotroph cell population within the pituitary gland, both in rats and in humans. We have also shown that, in absence of its ligand GDNF, RET induces activation o...

Background: Identifying the etiology of hypoglycemia in a non-diabetic patient is a significant challenge. Hyperinsulinemic hypoglycemia can lead to pancreatectomy in patients with no evident organic disease. Insulin autoimmune syndrome (IAS) or Hirata diseaseand Type B insulin resistance syndrome are the two typesof autoimmune hypoglycemia, with a low worldwide prevalence.Objective: We report two real-lifecases that illustrate each of them.<p class=...

Introduction: The aim of this work is the evaluation of usefulness of radioactive seed localization (RSL) for the detection of cervical recurrence of thyroid cancer in order to improve the surgical outcome.Material and method: Six patients with thyroid cancer with cervical recurrences evidenced by ultrasound, cytology/Tg-FNAB were selected for this procedure. A 125I seed was placed in the metastatic lesion using a needle guided by ultrasound. ...

It is widely accepted that, in addition to serving as a repository for energy reserves, adipose tissue is an active endocrine organ that secretes a variety of signalling molecules, the adipokines, which play important roles in the regulation of metabolism, energy balance, feeding behaviour, vascular homeostasis and immunity. In particular, leptin, resistin and adiponectin have been implicated in energy and glucose homeostasis. Additional neuroendocrine functions have also been...

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...

Introduction: Macroprolactin (maPRL) is a high molecular weight variant of prolactin (PRL) which has reduced bioactivity. The purpose of the present study was to determine the clinic-analytical repercussion of the presence of maPRL in patients with hyperprolactinaemia.Patients and methods: A polyethylene glycol (PEG) precipitation test was used to detect the presence of maPRL in all consecutive samples with prolactin levels >50 ng/ml (1060 mUIL). A r...

ObjectivesTo present the results of our series of endoscopic surgery of PA, performed in a third level hospital by an experienced team.MethodsRetrospective review of PA undergoing endoscopic surgery between 2011 – 2018 in our institution. Clinical variables and radiological characteristics and outcomes were collected at diagnosis, before surgery and for an average of 4.8 years of postoperative follow-up....