Endocrine Abstracts

In males, peak bone mass as evaluated by DXA is reached at the age of 20–22 years and may be important for the risk of fracture later in life. DXA, however, only provides two-dimensional images and does not allow assessment of bone structure.We used HR-pQCT to assess trabecular and cortical volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia in a population based study including healthy male volunteers. Moreover, bone str...

Over the last several years, we have generated low molecular weight (LMW) antagonists of the TSH receptor (TSHR) that have the potential to be developed as drugs to treat patients with Graves’ hyperthyroidism (GD)/Graves’ ophthalmopathy (GO) and thyroid cancer. As GD is caused by persistent, unregulated activation of TSHRs by thyroid-stimulating antibodies (TSAbs) on thyrocytes and GO may be caused by activation of TSHRs on retro-orbital fibroblasts, a LMW TSHR antag...

Aim: Following the general concern regarding the association between various diabetes treatments and cancer risk, the present study evaluated the cancer specific mortality in adult insulin-treated diabetes patients.Materials and methods: All diabetes patients residing in a major urban area, aged over 40 years and receiving insulin treatment were included at the moment of their first diabetes outpatient visit from 01/01/2001 to 12/31/2008. A total of 1136...

Introduction: Cushing’s syndrome caused by adrenocorticotropic hormone-producing pheochromocytoma has been rarely reported. In such cases, the high production of ectopic adrenocorticotropic hormone produced by pheochromocytoma results in bilateral adrenocortical hyperplasia and thus in consecutive Cushing’s syndrome. We report a case of a 43-year-old patient with a 6 cm right-sided adrenal tumor producing both elevated levels of catecholamines and adrenocorticotropic...

This cross sectional single centre study was performed at an endocrine center in northern India (latitude 29°42′N and longitude 77°02′E) to assess the prevalence of vitamin D deficiency in 234 symptomatic women presenting with musculoskeletal symptoms. The study was conducted during winter (Nov 2010–Jan 2011).Subjects were recruited from patients attending the OPD for various musculoskeletal symptoms. Inclusion criteria were sy...

Cyclic Cushing’s syndrome (CysCS) is one of the peculiar types of Cushing’s syndrome, characterized by the iteration between remission and recurrence. The precise mechanism in which the hormonal activity is changed suddenly has not been determined, while several hypotheses have been presented. Here, we report a case of CysCS which was induced remission dramatically by dopamine agonist.A 67-years-old woman was pointed out increasing ACTH and cor...

Introduction: Sheehan’s syndrome presents with hypopituitarism of variable severity after parturition usually preceded by post partum hemorrhage. Recovery of lactotroph function after initial insult has not been reported in the literature.Case report: A 41-year woman delivered her 1st child in 1994 at the age of 25 years, complicated by profuse vaginal bleeding and received two blood transfusions at a city hospital. She had lactation failure ...

Introduction: Current treatment for SIADH related hyponatremia is unsatisfactory. We describe two cases of effective Tolvaptan use in SIADH related to disseminated cancer.Case 1: Fifty-three year old female with metastatic ovarian carcinoma, vomiting from partial intestinal obstruction, was referred with sodium 121 mmol and normal renal function. She was clinically dry and mildly confused. SIADH was confirmed but urine Na was <10 suggestive of hypovo...

To better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases, our laboratory has recently generated a novel mouse model of the severe paediatric diseases caused by mutations in the LHX3 transcription factor gene. Through gene targeting, we have produced an Lhx3 W227Ter mouse modeling the LHX3 W224Ter (loss of carboxyl terminus) human disease. Patients with the W224Ter mutation are of short stature and ...

Introduction: De la Chapelle syndrome (46XX male syndrome) is a rare anomaly with the characterstics of discordant chromosomal and gonadal sex. Individuals with classical 46XX male sex reversal syndrome have an apparently normal male phenotype and presents with infertility or sub-fertility.Case report: Twenty five year old male, married 2 years back, came to take opinion regarding his Infertility. He is a healthy looking male with well developed secondar...