Searchable abstracts of presentations at key conferences in endocrinology

ea0028pl1biog | Society for Endocrinology Dale Medal Lecture | SFEBES2012

Society for Endocrinology Dale Medal Lecture

S Korach Kenneth

Kenneth S Korach, Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health Sciences, NIH, North Carolina, USA AbstractKenneth S. Korach is the Director of the Environmental Disease and Medicine Program, Chief of the Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health Sciences.He received his Ph...

ea0026s20.1 | Thyroid function: it is in your genes | ECE2011

Genetics versus environment: what determines thyroid function?

Hansen P S

The circulating levels of serum TSH and thyroid hormones represent biochemical phenotypes reflecting thyroid homeostasis. Studying the regulation of biochemical measures related to the thyroid in healthy individuals could prove essential in understanding the pathways that eventually lead to thyroid disease. It is the combined effect of genetic and environmental factors that give rise to these endophenotypes. It has been established that the measures reflecting thyroid homeosta...

ea0026p410 | Thyroid (non cancer) | ECE2011

Lithium in the acute preoperative preparation of thyrotoxicosis: a case series

Dampetla S , Malik M

Introduction: Thionamides are first line treatment in the management of thyrotoxicosis; nevertheless several weeks of treatment is needed before euthyroidism is restored. This delayed and gradual action makes thionamides insufficient as sole treatment when acute control of the hyperthyroid status is mandatory, hence the need for potent yet rapid acting adjuvant antithyroid agent. Lithium is a monovalent cation that inhibits thyroid iodine uptake and hormone release with maximu...

ea0026p698 | Diabetes complications | ECE2011

Illuminating diabetic neuropathy: novel systems for in vivo monitoring and microenvironmental investigations in a murine model

Amit S , Yaron A

Introduction: Major advances in the research and treatment of diabetes-related neuropathic phenomena are hampered due to its complicated pathophysiology and the scarcity of valid experimental models. The aim of this study was to establish novel systems facilitating monitoring and dissection of processes central to the development of diabetic neuropathy.Methods: In a non-invasive in vivo model, two-photon microscopy is used to detect and assess mec...

ea0026p737 | Diabetes (epidemiology, pathophysiology) | ECE2011

Linking CERN and TERM: testing the acceleration hypothesis

Dautovic S , Dautovic R

Objective: Catch-up growth might be associated with metabolic risk later in life. The β-cell has a higher energy requirement and poor antioxidant defense. The accelerator hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views diabetes as the one disorder of insulin resistance, set against different genetic backgrounds. Insulin resistance is a function of fat mass, and increasing body weight is accompanied by earlier presentati...

ea0025pl9 | Clinical Endocrinology Trust Lecture | SFEBES2011

Pituitary tumours: the goal is shrinking!

Bevan John S

In 2011 is the 40th anniversary of prolactin (PRL) characterisation as a distinct hormone. Only 30 years ago most patients with large pituitary tumours received primary surgery (often transcranial) followed by routine radiotherapy – treatments associated with significant morbidity and hypopituitarism. Much therapeutic progress has been made; effective medical treatments now exist for many pituitary tumour subtypes, particularly the use of long-acting dopamine agonists (DA...

ea0025pl9biog | Clinical Endocrinology Trust Lecture | SFEBES2011

Clinical Endocrinology Trust Lecture

Bevan John S

John S Bevan, Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. AbstractJohn S Bevan is senior Consultant Endocrinologist at Aberdeen Royal Infirmary and Honorary Professor of Endocrinology at Aberdeen University. He qualified MB ChB, with Honours, from Edinburgh University in 1978 and his clinical training in Medicine & Endocrinology took place in Edinburgh, Oxford and Ca...

ea0024p34 | (1) | BSPED2010

Undefined diabetes unfolds

Senniappan S , Smith C

Introduction: Although type 1 diabetes is the most common type of diabetes in children, with the steady increase in type 2 and rare forms of diabetes, it may be sometimes difficult to ascertain the type of diabetes at the time of presentation. Some children present with a combination of features and do not fit into one of the classical types of diabetes. The rapid progress in the molecular genetics has helped to identify the specific diagnosis for these rare forms of diabetes....

ea0024p45 | (1) | BSPED2010

Metabolic bone disease of prematurity

Rajput S , Dutta A

Premature infants are at significant risk of reduced bone mineral content and osteopenia. Inadequate phosphate and calcium uptake in-utero followed by poor postnatal intake in the presence of high growth velocity leads to metabolic bone disease in premature babies. It is not due to vitamin D or parathyroid hormone deficiency.There is no national or international consensus on how to prevent or manage this condition leading to varied practice across the di...

ea0024p58 | (1) | BSPED2010

Persistent hypernatremia in infants…think diabetes insipidus

Iyer D , Karandikar S

Introduction: Central diabetes insipidus (CDI) in infants is rare and is often associated with intra-ventricular haemorrhage, congenital toxoplasmosis, intracranial tumours and anatomical abnormalities of the brain. We describe two cases of CDI associated with brain malformations, diagnosed at very young age with good response to oral DDAVP.Case 1: A 34-week IUGR girl born to consanguineous parents (first cousins) developed hypernatraemia on day three of...