Endocrine Abstracts

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

Mineral-rich baths and other spa treatments are popular and are promoted as providing a sense of well-being and detoxification. However, exposure to minerals that are easily absorbed through the skin may have unwanted adverse effects in certain groups of patients. In 2001, a 50-year-old woman was diagnosed with thyrotoxic Graves’ disease. Her thyroid peroxidase antibodies were >1000 IU/ml. She was treated with block and replace therapy for 1 year. She remained euthyro...

Case report: A 68 year old lady was admitted for an elective partial hepatectomy for a solitary metastasis in the liver. Two years ago she had an uneventful colectomy for a colorectal cancer. During induction for her operation she was noted to be hypertensive {blood pressure (BP) 200/120 mm of mercury (Hg)}, though had not been observed to be so previously, and hence her partial hepatectomy had to be abandoned. She was commenced on atenolol and operation rescheduled. The secon...

Although double adenomas may be present in 1% of autopsy pituitaries, in patients with pituitary disease they are extremely rare. In previously reported surgical series an incidence of 0.37–1.64% has been observed. We report a 55 year old lady with features suggestive of acromegaly and a double pituitary adenoma on MRI. The diagnosis of acromegaly was confirmed by an elevated serum IGF-I and a nadir growth hormone of 10.3 mU/l during a 75 g oral glucose tolerance test. Ot...

Vasotocin (AVT), the avian homolog of vasopressin, is synthesized in the BSTM of chickens in addition to the hypothalamo hypophysial axis. In previous reports, sex specific AVT–immunoreactivity(ir) in male BSTM (Jurkevich et al. 1999) and it’s ontogeny were demonstrated (Grossmann et al. 2002). In addition, galanin (Gal) was found in male BSTM co-localized to AVT. In the present study, the ontogeny of AVT- and Gal-ir was investigated in the SON as part ...

Urinary N-Acytyl β-D glucoseaminidase EC: 3.2.1.31 is a lysosomal enzyme which is classified in hexosaminidases group. This enzyme is found in different tissues such as, kidney, liver and spleen, but the kidney has maximum level of enzyme.The first step was the standardization of colourimetry and flourimetry of enzyme assay. In colourimerty method para-nitrophenyl N-acetyl β-D-glucosamine is used as substrate and in flourimetry method the subst...

Introduction: Radioiodine (Iodine-131) is a widely used treatment for thyrotoxicosis. Fluctuation in thyroid hormone levels following radioiodine treatment is common. Hypothyroidism occurs in approximately 5.5% of patients per month in the first 6 months, with onset time hard to predict. In contrast, some patients remain hyperthyroid either due to persistent pre-radioiodine thyrotoxicosis or transient exacerbation following radioiodine. We examined whether the block & repl...

Polycystic ovarian syndrome (PCOS) is associated with insulin resistance. Since pregnancy is also known to induce insulin resistance, it is expected that pregnant women with PCOS might be at increased risk for impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) which might affect the pregnancy outcome. The incidence of IGT/GDM in PCOS women has not been adequately assessed. The aim of the study was to evaluate glucose tolerance and pregnancy outcome in a g...

AimAssessment of surgery efficacy in patients with MTC.MethodsWe used DNA extracted from 53 patients with MTC. All samples were subjected to PCR. Radio-immunological examination, serum CT measurement was performed by means of commercially available kit RIA DCL-1200. Basal calcitonin (CT) levels higher than 100 picograms per ml and the stimulated CT levels are accepted as pathological and typical of MTC.<p...

Background Somatostatin has various biological effects such as modulation of exocrine and endocrine secretions, proliferation and apoptosis. These effects have been shown to be mediated via G-protein linked receptors known as somatostatin receptors 1-5 (SST 1-5). It has been shown that SST 2 in particular can be modulated by estrogen. The phytoestrogen genistein acts through the estrogen receptor beta and has been shown to have opposing effects on cell proliferation at differe...