Endocrine Abstracts

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The relentless rise in the prevalence of obesity predicts an exponential increase in the incidence of obesity-related complications. Whereas preventative lifestyle measures must remain the cornerstone of management for the population at large, there remains a growing cohort of patients who remain in the severe obese (BMI>40 kg/m2) category and who suffer from the associated co-morbidities. Medical treatments may be sufficient for lesser degrees of obesity, for t...

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S Hillier, University of Edinburgh, Edinburgh, United Kingdom AbstractSteve Hillier is Professor of Reproductive Endocrinology at the University of Edinburgh, where he has directed infertility laboratory services at the Royal Infirmary of Edinburgh and undertaken research at the Centre for Reproductive Biology for over 20 years. Previously (1982–1985), working with Robert (now Lord) Winston, he established the <i...

G Risbridger, Monash University, Melbourne, Australia AbstractProfessor Risbridger, a founding member of the Monash Institute of Medical Research, currently heads the Institute's Centre for Urological Research (CURe). She leads a team of investigators who aim to better understand prostate disease leading to better diagnosis and treatment of both benign and malignant prostate disease. Professor Risbridger is a Fulbright...

VKK Chatterjee, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom AbstractKrishna Chatterjee graduated from Cambridge and completed his clinical training in Oxford. He first trained in endocrinology at Hammersmith Hospital, London and subsequently undertook research in the Thyroid Unit at Massachusetts General Hospital, Boston. In 1990, he returned to Cambridge as a Wellcome Senior Clinical Res...

C Strasburger, Charite Campus Mitte, Berlin, Germany AbstractSince 2003 Christian J Strasburger has been Division Chief and Professor of Clinical Endocrinology at the Department of Medicine at Charité-Universitätsmedizin Berlin, Germany. He graduated from the Medizinische Universität Lübeck, Germany and trained in internal medicine and endocrinology at the Universities of Lübeck and Munich. He ...

The testis provides stem cell niches which are populated by spermatogonial stem cells. The seminiferous epithelium is the exclusive site where germline cells are proliferating and entering meiosis in the adult organism. The existence of stem cells offers clinically relevant options for preservation and restoration of male fertility. New approaches based on male germ cell transplantation and testicular tissue grafting can be applied to generate sperm. Germ cell transplantation ...

Renin is a rate-limiting enzymatic component of the renin-angiotensin pathway controlling blood pressure in vertebrates. Using the zebrafish developmental model organism, we study how renin-secreting cells are established in a small region of the early embryo that gives rise to the developing pronephric kidney: the origin of these cells, the factors that induce the differentiation of this cell lineage, and the function of very early renin expression. This study aims to gain in...