Searchable abstracts of presentations at key conferences in endocrinology

ea0038p322 | Pituitary | SFEBES2015

Traditional cardiac risk factors in a cohort of hypopituitary patients: a preliminary look at the utility of QRISK2 score

Sivapackianathan Rasheeta , Suriyakumaran Jayani , Akker Scott , Drake William , Waterhouse Mona , Druce Maralyn

Introduction: Increased cardiovascular risk in hypopituitary patients was first documented by Rosen in 1990. Subsequent studies confirmed increased prevalence of cardiovascular and cerebrovascular disease in these patients. The exact mechanism for this is unclear. There is no clear consensus on how best to quantify or predict cardiac risk in hypopituitarism. QRISK2 cardiovascular disease risk algorithm provides estimates of 10-year cardiovascular disease (CVD) risk in patients...

ea0038p323 | Pituitary | SFEBES2015

Long term follow up of patients with craniopharyngioma

Glynn Nigel , Windt Raquel Sanchez , Waterhouse Mona , Akker Scott , Drake William , Druce Maralyn

Introduction: Patients with craniopharyngioma are characterised by a high incidence of hypopituitarism, visual failure and hypothalamic dysfunction. Standardised mortality is markedly elevated and controversy exists about optimal treatment.Aim: We aimed to examine the temporal trends in the treatment of craniopharyngioma at our centre. Also, we sought to examine treatment needs and long-term morbidity in this patient group.Methods:...

ea0034p180 | Neoplasia, cancer and late effects | SFEBES2014

Characteristics of ‘foregut’ carcinoid tumours occurring in multiple endocrine neoplasia type 1

Yang Lisa , Mann Kirsty , Winceslaus Julian , Khan Roaid , Akker Scott , Waterhouse Mona , Drake William , Druce Maralyn

Background: The glands most commonly affected in MEN1 are parathyroid, pituitary and pancreas. Pancreatic neuroendocrine tumours (pNETs) are of foregut origin, but a number of other so-called ’foregut carcinoid tumours’ may also occur in MEN1, including tumours of bronchial, thymic, and gastrointestinal origin. Reported rates of prevalence of these latter tumours vary from 2% for thymic and bronchial carcinoids, to 10% for gastric carcinoids. Thymic carcinoids have b...

ea0070aep641 | Pituitary and Neuroendocrinology | ECE2020

Medical treatment leading to remission of ectopic cushing’s syndrome

Seguna Desiree , Shiafkou Marianna , Sahdev Anju , Al-Mrayat Ma’en , Akker Scott

A 35 year-old lady presented to her local hospital with a 3 year history of fatigue, weight gain, recurrent tonsillitis and oligomenorrhoea. Examination revealed facial plethora, round facies and thin skin on the dorsum of the hand. She appeared tanned, with evidence of spontaneous bruising and difficulty standing up from a chair unaided. No striae were present. Blood pressure was 152/91 mmHg. Investigations revealed a 0900 h cortisol of 632 nmol/l (ACTH 59 ng/l) and an elevat...

ea0070ep542 | Hot topics (including COVID-19) | ECE2020

COVID-19 infection in a patient with life-treatening hypercalcaemia and sickle cell disease

Seguna Desiree , Marshall Henry , Barroso Filipa , Parvanta Laila , Adams Ashok , Berney Daniel , Akker Scott , Cavlan Dominic

A 21-year-old woman with homozygous sickle cell disease, presented to A&E with vomiting and diarrhoea, and was noted to be hypercalcaemic (corrected calcium 3.00 mmol/l [ref. 2.2–2.6]; phosphate 0.48 mmol/l [ref. 0.8–1.5]). She reported polyuria and polydipsia, but no other symptoms of hypercalcaemia. There was no history of renal stones, renal impairment, or fragility fracture. A maternal aunt required parathyroidectomy in middle age. Bloods revealed PTH 138.4 pmo...

ea0031p65 | Clinical practice/governance and case reports | SFEBES2013

Peri-operative α-blockade: efficacy of intravenous phenoxybenzamine vs oral phenoxybenzamine in patients with phaeochromocytoma and paraganglioma

Hussain Shazia , Gunganah Kirun , Ashby Michael , Carpenter Robert , Waterhouse Mona , Druce Maralyn , Drake William , Akker Scott

Introduction: Regimens for pre-operative α and β-blockade for patients with secretory phaeochromocytomas/paragangliomas vary widely between centres. The worldwide lack of availability of intravenous phenoxybenzamine (Goldshield) has removed a useful tool in the management of phaeochromocytoma crisis and has necessitated a change in our institution’s routine pre-operative strategy. We compare pre, peri and post-operative surrogate measures of blockade in a cohort...

ea0028p27 | Clinical biochemistry | SFEBES2012

Using the hyperaldosteronism cohort to define normative catecholamine levels for adrenal venous sampling

Sze Wing-Chiu , Matson Matthew , Druce Maralyn , Akker Scott , Chew Shern , Grossman Ashley , Drake William

Objective: (1) To review normative data for catecholamines using our cohort of hyperaldosteronism patients undergoing adrenal vein sampling. This adds to the previously published data of normative values in a cohort of patients with cortisol-producing adenoma. (2) To demonstrate the usefulness of the noradrenaline to adrenaline ratio in the interpretation of adrenal venous sampling results.Design: 38 patients underwent successful, bilateral adrenal venou...

ea0021p115 | Clinical practice/governance and case reports | SFEBES2009

Endocrinopathy and low bone mineral density in thalassaemia

Waterhouse Mona , Gorrigan Rebecca , Thomas Aldine , Brooke Antonia , Telfer Paul , Kaya Banu , Akker Scott

Thalassaemia patients are transfusion dependent and at risk of iron overload with end organ damage. Iron deposition is reduced by chelation treatment. We present the data on endocrinopathy and bone density in the adult patients under our care with thalassaemia. In addition, we will discuss therapeutic approaches to these problems including the use of newer chelation agents and possible reversal of endocrine end organ damage. We will also review the correlation in our patients ...

ea0015p74 | Clinical practice/governance and case reports | SFEBES2008

An adrenaline-secreting phaeochromocytoma in pregnancy

Thomas Julia , Vearncombe Laura , Perry Les , Sanghi Anita , Carpenter Robert , Akker Scott

A 37-year-old woman, 30 weeks pregnant, presented with palpitations and abdominal cramps. Ultrasound demonstrated a supra-renal abnormality and MRI showed a 10 cm heterogeneous left adrenal mass. For five years she had experienced episodes of palpitations, shaking, sweating and chest tightness. She was investigated by a neurologist and diagnosed with temporal lobe epilepsy. During pregnancy the frequency of episodes increased. Lamotrigine was started, but at each dose increase...

ea0015p91 | Clinical practice/governance and case reports | SFEBES2008

Growth hormone replacement in patients with treated germ cell tumours: safety issues

Chung Teng-Teng LL , Kelly Phillip , Metcalfe Karl , Akker Scott , Drake William , Monson John

The potential for primary tumour relapse is an important consideration during GH replacement therapy (GHR). We report 3 cases of relapse of intra cranial germ cell tumour (GCT) during GHR.Patient 1: An 11 year-old female presenting with visual loss and short stature due to a suprasellar malignant teratoma. She was successfully treated with bleomycin, etoposide and cisplatinum (BEP) and intrathecal chemotherapy. She suffered a first relapse two years late...