Searchable abstracts of presentations at key conferences in endocrinology

ea0021p135 | Diabetes and metabolism | SFEBES2009

Testosterone replacement therapy has no effect on ultrasound assessed carotid artery stiffness and intima-media thickness in men with insulin treated type 2 diabetes

Stanworth Roger , Jones T Hugh

Context: Testosterone replacement therapy (TRT) has shown benefit on insulin resistance, glycaemic control and cardiovascular risk markers in hypogonadal men with diabetes. Arterial stiffness and intima-media thickness (IMT) are vessel wall properties associated with future cardovascular risk which allow the progress of atherosclerosis to be assessed non-invasively. Low testosterone has been associated with the presence and progression of carotid atherosclerosis as assessed by...

ea0019p47 | Clinical practice/governance and case reports | SFEBES2009

A case of a disappearing adrenal mass with raised urine catecholamines

Jones A , Fox T , Browne D

Introduction: Adrenal incidentalomas are a common reason for endocrinology referral. We present a case of an incidentally discovered adrenal mass biochemically mimicking phaeochromocytoma with rapid resolution on subsequent imaging.Case report: A 53-year-old female was found to have a 5 cm mass adjacent to the right kidney on ultrasound performed to investigate abnormal liver function tests. CT confirmed a right adrenal mass. The patient was normotensive...

ea0019p328 | Steroids | SFEBES2009

Homeopathic medication and hyperthalamic–pituitary–adrenal (HPA) axis

Hawkins A , Boochandran T , Nikookam K

The aim of these two case reports (husband and wife) is to highlight the importance of homeopathic medication on HPA axis.The first case is a 60-year-old Indian lady known to have diabetes mellitus, hypertension and hypercholesterolaemia, who presented with difficulty in losing weight and generalised aches and pains. As part of the investigations by her General Practitioner her serum cortisol was found to be low at 32 mmol/l. Short synacthen test showed ...

ea0012p135 | Thyroid | SFE2006

Tri-iodothyronine, how does it get in? What if it goes wrong?

Dugal T , McEntagart M , Albanese A

Thyroid hormone is absolutely necessary for early brain development. Incidence of thyroid disorders in infancy is 1:4,000. Thyroid hormones can be deficient through hormone synthesis and action or very rarely through defective transport. Some new and exciting transporters for tri-iodothyronine (T3) have recently come to light. MCT 8 gene encodes the protein that transports T3 into neurons. Its mutation result in inability of T3 to enter a devel...

ea0011p166 | Clinical case reports | ECE2006

Dysgerminoma and gonadoblastoma in children with complete androgen insensibility

Noczynska A , Zak T , Salmonowicz B

Children with androgen insensibility and female sexual external organs usually are classified as girls. In the puberty observed is the development of female secondary sexual features without menstruation. The treatment of patients with androgen insensibility, because of the risk of neoplastic transfomation must be preceded by castration. Case report: a 14 year old girl was admitted in 2003 to the Clinic with the following anamnesis: birth from the secondary gravidity, normal d...

ea0009p175 | Thyroid | BES2005

An audit of the outcome of a fixed dose (555Mbq)of radioidine for hyperthyroidism

Abdalla T , Khan S , Wilton A

BackgroundRadioiodine therapy (RAI) is an effective treatment for hyperthyroidism, being used with increasing frequency. There is no consensus as to the correct use of radioiodineThe aim is to compare our practice to the standards recommended by the working group of the Royal College of Physicians and Society for Endocrinology and to measure the outcome at one year of using a fixed dose of RAI (555 Mbq) .Meth...

ea0005p17 | Clinical Case Reports | BES2003

A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density

Abdalla T , Owen A , Curtis A , Wilton A

Mutations of the DAX-1 gene cause X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. Two half brothers (same mother, different fathers) were diagnosed as having Addison's aged14 years (brother A) and 7 years (brother B). Their mother had haemochromatosis being homozygous for the Cys 282 Tyr mutation of the HFE gene. Both had delayed pubertal development but defaulted from follow up. Brother A re-presented at 29 years of age with infertility. In view of t...

ea0003p35 | Clinical Case Reports | BES2002

Iatrogenic Acromegaly

Tuthill A , McKenna T , O'Shea D

Acromegaly is a condition resulting from the action of excess growth hormone. We report the first case of acromegaly occurring in an individual as a result of growth hormone replacement therapy.Features of acromegaly developed in a forty-year old gentleman who was commenced on growth hormone replacement in 1993 following resection of a craniopharyngioma. Prior to commencing therapy, peak growth hormone response to insulin-induced hypoglycaemia was less ...

ea0094p250 | Neuroendocrinology and Pituitary | SFEBES2023

Hypophysitis secondary to monoclonal antibody treatment

Anand Viswesh , T Srinivasan Balasubramanian

Background: Immunotherapy has become one of the standard interventions to treat various malignancies and auto-immune conditions with favourable responses to the treatment. However, the immune related adverse events of these medications are diverse which may include a variety of endocrinopathies, like Hypo cortisol, Hypophysitis, hypo and hyperthyroid states.Case report: A 62 year old female with a background of Metastati...

ea0029p21 | Adrenal cortex | ICEECE2012

Predicting factors of the post-surgical decline in renal function in patients with primary aldosteronism

Nakao K. , Nanba K. , Tamanaha T. , Tsuki M. , Tagami T. , Usui T. , Shimatsu A. , Naruse M.

Primary aldosteronism (PA) is the most common cause of secondary hypertension. Although decline in renal function especially that experienced after adrenalectomy (ADX) has been demonstrated, details of the mechanism remain to be elucidated. Aim of the study was to investigate the factors predicting renal outcome after ADX in PA. Twenty patients with PA and four patients with non-functioning adrenal tumor (NFT) as control were studied. eGFR, serum potassium, plasma aldosterone ...