Endocrine Abstracts

Introduction: Optimal glucocorticoid (GC) replacement in patients with adrenal insufficiency (AI) is desirable for the prevention of long-term side effects of GC. Both hyperglycemia and hypoglycemia are the risk of atherosclerosis. For the determination of optimal GC replacement method in patients with AI, we tested a utility of continuous glucose monitoring (CGM).Subjects and methods: Three patients with primary or secondary AI were examined. Case 1, 50...

Introduction: An increase in thyroid diseases after the Chernobyl, mostly due to radioactive iodine, has been scientifically recognized. It is also known the effect of nitrate on iodine metabolism: being a competitive inhibitor of sodium-iodine symporter nitrate prevents iodide uptake by the thyroid and compromises thyroid hormone synthesis.The aim of the study was to investigate the incidence of thyroid and salivary glands’ abnormalities by ultraso...

Background: Impaired circadian blood pressure (BP) variation is a frequent phenomenon in hypertensive type 2 diabetic (T2DM) patients (pts), and is considered a risk factor for development of cardiovascular complication. The aim - to assess the effect of Lacidipine on left ventricular mass (LVM) and BP in hypertensive T2DM pts.Materials and methods: Totally 32 T2DM pts with mild-to-moderate hypertension (20 m/12 f, mean age 57±9.6 yrs) were allocate...

The objective of the study was to assess the effect of intra-muscular testosterone on constitutional symptoms, sexual symptoms, memory and in men with hypogonadism and poorly-controlled type-2 diabetes. This is a randomised double-blinded placebo-controlled add-on trial of intramuscular testosterone undecanoate(Nebido®) administered every 12 weeks in 65 hypogonadal men with poorly-controlled diabetes. Phase-1 patients were randomly assigned to either treatment ...

Objectives: The goal of this study was to evaluate the value of a TRH stimulation test to assess the risk of permanent central hypothyroidism after transsphenoidal pituitary surgery.Methods: A retrospective cohort study was performed, evaluating the results of a routinely performed TRH stimulation test executed in the first 2 weeks after transsphenoidal pituitary surgery in patients admitted to the Ghent University Hospital between 1/1/2010 and 31/12/201...

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: from April 2014 to November 2018, 122 pati...

Issues: In developing nations diagnosis of diabetes brings mental-trauma/depression in family. Focused treatment for pediatric age-group is unavailable in developing-countries. 26% of diagnosed diabetics are children’s. Adequately trained physicians/Nurses in issues of pediatric-diabetes provide continuity of care, relief from depression and smooth transition from diagnosis to treatment. Qualitative collaborative relationship between these makes diabetics life bearable. O...

Background: Endocrinology, taught in Year 2 of the Edinburgh undergraduate MBChB curriculum to approximately 200 medical students, can present a complex challenge and a test of engagement. Core biomedical curriculum content is delivered as large group teaching (lectures) and then revisited in smaller groups (clinical-cased based tutorials, PBL) designed to integrate learning by applying basic knowledge in a clinical context. PBL first implemented in the 1960s at McMaster Unive...

Case history: 63 year man with two trans-temporal incomplete resections of a glomus jugulare tumour (HNPGL) in 1993 and 2000 with regular surveillance scans for residual disease. Eight years later, an MRI demonstrated an incidental pituitary macroadenoma with cavernous and sphenoid sinuses invasion. The patient was asymptomatic but, his biochemistry revealed a markedly raised prolactin of 43,000 mIU/l with no other pituitary hormone deficiency. Cabergoline was commenced and th...

Case history: A 59-year-old lady with a background of type 2 diabetes, hypercholesterolemia and hypertension presented with a 3-week history of progressively worsening central abdominal pain and vomiting. Her drug history included bezafibrate and atorvastatin on which she was unable to meet her cholesterol and lipid targets and hence were stopped two weeks prior to her admission. The plan had been to start once fortnightly Alirocumab, a PCSK9 inhibitor; which had been delayed ...