Searchable abstracts of presentations at key conferences in endocrinology

ea0007p236 | Thyroid | BES2004

Hypothyroidism is less frequent following radioactive iodine treatment for toxic nodular goitre than Graves' disease

Adamali H , Gibney J , McKenna T

Since the thyroid is diffusely active in Graves' disease (GD) but exhibits focal activity in toxic nodular goitre (TNG), we tested the hypothesis that hypothyroidism will occur more frequently following radioactive iodine treatment (RAI), in patients with GD compared to those with TNG. To do this we reviewed the outcome of treatment in 86 patients, age 49.7 plus/minus 1.5 years (mean plus/minus SEM), with GD, and 77 patients, age 62.7 plus/minus 1.3 years, with TNG, followed o...

ea0007p271 | Clinical case reports | BES2004

Normoprolactinaemic galactorrhoea in a male-to-female transsexual

Barber T , Basu A , Rizvi K , Chapman J

Hormonal therapies in the form of oestrogens, anti-androgens and progestogens are often used in the treatment of male-to-female transsexuals. We present the case of a 36 year old phenotypic male with karyotype 46XY who presented with normoprolactinaemic galactorrhoea likely to be related to prior oestrogen administration. He had been self-administering oestrogen and progesterone preparations continuously for 7 years (aged 26 - 33 years) in an attempt to develop female phenotyp...

ea0007p286 | Clinical case reports | BES2004

Porphyria cutanea tarda complicated by primary hepatocellular carcinoma

Arutchelvam V , McCulloch A , Senadhira T , Nag S

The porphyrias encompass a group of disorders characterized by inherited or acquired derangements in the biosynthesis of heme.Porphyria cutanea tarda is the most common form and is characterized by chronic skin lesions and hepatic disease.It may rarely be complicated by hepatocellular carcinoma. We present a 67 year old man who presented with hepatocellular carcinoma on a background of previous porphyria cutanea tarda.The patient was diagnosed with Type ...

ea0007p293 | Clinical case reports | BES2004

Ectopic pancreas presenting as dyspepsia

Kapoor D , Azmy M , Jones T

A previously well 55 year old man presented to his family practitioner with asix week history of dyspepsia. He denied any other symptoms including no weight loss. Clinical examination was normal.A gastroscopy was organised which revealed a 10 millimetre sessile polyp located at greater curvature at the lower body of the stomach. The polyp was removed by snaring. Histological examination of the polyp revealed heterotopic pancreatic ...

ea0006s25 | Steroid replacement | SFE2003

AN AUDIT OF SELF-CARE OF PATIENTS ON HYDROCORTISONE REPLACEMENT THERAPY

Kieffer V , Robinson C , Howlett T

Patients with hypoadrenalism are at risk of life-threatening events if they do not receive adequate glucocorticoid replacement during intercurrent illness. We think that these patients should know when and how to adjust their steroid dose when ill. We also think they should possess, and know how to give themselves, an injection of hydrocortisone for emergencies.Current education is given ad hoc at clinic visits, supported by written information, but ther...

ea0006oc19 | Growth and Development | SFE2003

DIFFERENTIAL EFFECTS OF MATERNAL NUTRITION ON MOLECULAR INDICES OF FETAL ADIPOSE TISSUE DEVELOPMENT AND FUNCTION

Bispham J , Stephenson T , Symonds M

Introduction: Fetal fat comprises both brown and white adipocytes. Brown fat possess a unique uncoupling protein 1 (UCP1), whose abundance is regulated in part by the prolactin receptor (PRLR), whereas white fat is characterised as secreting leptin. The present study aimed to determine if the relationship between mRNA abundance for each of these molecular indices of adipose tissue function was nutritionally regulated.Methods: Twenty singleton-bearing ewe...

ea0006p3 | Clinical case reports | SFE2003

PROFOUND HYPOTHYROIDISM IN A PATIENT WITH LACTOSE INTOLERANCE

Kapoor D , Adekunle D , Jones T

A 55 year old lady was referred by her general practioner with a six months history of generalised lethargy and cold intolerance.This was associated with abdominal bloating and constipation.She had been more irritable recently and was getting depressed. She also described symptoms suggestive of carpal tunnel syndrome. The only past history of note was of lactose intolerance.There was no family history of thyroid disorder.On examination she was clinically...

ea0006dp19 | Diabetes, metabolism and cardiovascular | SFE2003

Effect Of The Mode Of Conception On Incidences Of Apoptotic And Proliferative Cells In Full Term Human Placentas

Basir G , Cheung P , Cheung A , Lao T

Objectives: To compare the cell dynamics of term placental tissue in pregnancies conceived by in-vitro fertilization (IVF) and embryo transfer with spontaneous pregnancies.Methods: Placental samples were obtained from singleton term IVF pregnancies (n=25) and singleton term spontaneous pregnancies (n=30). Ethical approval was obtained from the Faculty of Medicine, The University of Hong Kong. The incidence of apoptotic and proliferative cells was determi...

ea0005oc9 | Cardiovascular Endocrinology | BES2003

Use of glucocorticoids and risk of cardiovascular disease in a population-based cohort study of 164,133 participants

Wei L , MacDonald T , Walker B

Context: Glucocorticoids have adverse systemic effects which may predispose to cardiovascular disease. The effect of glucocorticoid use on cardiovascular disease has not been assessed.Objective: To test the hypothesis that users of exogenous glucocorticoids have a dose-dependent increased risk of cardiovascular disease; in particular, that supraphysiological doses will be associated with cardiovascular disease.Design: A cohort study using a record linkage database....

ea0005p16 | Clinical Case Reports | BES2003

Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic) hermaphroditism: Serial high-resolution ultrasound characterisation

Barber T , Ball S , Elliott S

An ovo-testis (a gonad showing aspects of both ovarian and testicular function) occurs in some 60% of true hermaphrodites. They may be located in the labio-scrotal folds, inguinal canal or abdomen and are often removed prior to or shortly after the onset of puberty. Though the potential for ovulatory function within such a gonad is acknowledged, it is rarely witnessed and there are few detailed descriptions of the phenomenon. We describe serial observations of this process in ...