Endocrine Abstracts

Although over 50 type 2 diabetes (T2D) loci have been identified through genome-wide association studies (GWAS), the vast majority of the genetic predisposition to T2D still remains to be clarified. One explanation is that despite the use of high-throughput genotyping arrays, only a small proportion of genetic variants in the human genome are actually surveyed, especially in non-European populations. We explored the comprehensive catalog of genomic variations provided by the 1...

Purpose: To investigate the impact of depression for diabetes-related quality of life and glycemic control among Japanese patients with type 2 diabetes and their family members.Methods: Ambulatory patients with type 2 diabetes were drawn consecutively from the inpatient population participated in a 2-week educational intervention program at two general hospitals affiliated with Hiroshima University. Written informed consent for the study was obtained fro...

Rationality: T2DM is a component of the metabolic syndrome, the occurrence of overweight, arterial hypertension (AH), and dyslipidemia in T1DM is variable according to the literature.Objective: Study of the occurrence of overweight, AH and dislipidemy in T1DMMaterials and methods: Total 726 patients with T1DM (348m, 378f), mean age (M±σ) 34.71±0.58 yrs (1–78), age of T1DM manifestation 12.41±0.36 yrs and sp...

Introduction: Up to 10% of patients with congenital hypogonadotropic hypogonadism (HH) may undergo reversal of hypogonadotropism and some of them even attain normal sperm count in adulthood. However, clinical and molecular genetic features of these patients and the triggers leading to reversal of HH are not well understood. We studied whether Finnish reversal variants displayed a common phenotypic or genotypic feature that would predict the clinical course of HH.<p class="...

Perinatal undernutrition is known to disturb reproductive development, in particular by delaying the onset of puberty in certain species. Using a rat model, we studied whether hypernutrition after birth can rescue the delayed onset of puberty in intrauterine undernourished female rats. Pregnant rats were divided into two groups the maternal normal nutrition (mNN, n=8) and maternal undernutrition (mUN, n=9) groups. In the mUN group, dams received 50% of the daily ...

Introduction: C-reactive protein (CRP), an acute reactant protein and member of the pentraxins family has a primitive defense function against exogenous organisms. Although its production is predominantly under the control of IL-6, IL-1 and tumor necrotic factor also contribute to hepatic synthesis and CRP secretion. CRP is mainly produced in the liver and possibly other tissues, such as atherosclerotic lesions. C-reactive protein (CRP) is associated with increased risk for ca...

Introduction: The objective of this study was to investigate left atrial mechanical function (LAMF) and to associate these measurements with diastolic function in subclinical (SHT) and overt hypothyroidism (OHT).Methods: Twenty-six newly diagnosed patients with SHT (20F, 6M, mean age 42.2±12.5 years), 21 patients with OHT (17F, mean age 40.2±8.5 years) and 28 healthy volunteers (control group, 21F, 42.4±11.2 years) were enrolled in this st...

Materials and methods: The study included 58 patients (50 female, 8 males) aged from 38 to 60 years, have received surgical treatment for GD with the period of follow-up after treatment for 2 to 10 years. The patients were divided into 2 groups depending on the initial level of TSH. In the first group (33 persons) included patients with low-normal level of TSH (0.4–2.5 mU/ml), the in second group (25 persons) with upper-normal level of TSH (2.6–4.0 mU/ml). An estimat...

Materials and methods: The study included 58 patients (50 female, 8 males) aged from 38 to 60 years, have received surgical treatment for GD with the period of follow-up after treatment for 2 to 10 years. The patients were divided into 2 groups depending on the initial level of TSH. In the first group (33 persons) included patients with low-normal level of TSH (0.4–2.5 mU/ml), the in second group (25 persons) with upper-normal level of TSH (2.6–4.0 mU/ml). Quality of...

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...