Endocrine Abstracts

T Yoshimura, Nagoya University, Nagoya, Japan AbstractProf. Takashi Yoshimura graduated from the Graduate School of Agriculture, Nagoya University in 1996. In 1995 he was awarded the JSPS Research Fellowship for young scientists and between 1996 and 1999 he worked as a Research Associate at the School of Agriculture, Nagoya University. At the same institution he was Assistant professor until 2005 and later became the ...

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The spectrum of thyroid problems seen in paediatric endocrine practice is different to that seen in later life. Topics that have attracted particular interest include the HPT axis in pre-term infants, the significance of a subtle increase in TSH, and associations between thyroid function in childhood and risk of disease in later life. This talk will include lessons learnt from patients seen in North–East England and from studies conducted in the same locality.<p class...

Metabolism comprises anabolic (converting small molecules into big ones) and catabolic processes (converting food into useful energy), predicts the functional state of a cell, and analyzes the levels of the end products (metabolites) of anabolism and catabolism. Metabolic profiling using stable isotope tracer technology ([U-13C6] sugars) allows the measurement of the changing pattern of distribution of 13C carbons from [U-13C6</...

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Thyroid hormone is essential for the metabolic function of all tissues throughout life and for the development of different organs, notably the brain. Although the thyroid gland mainly secretes T4, most actions of thyroid hormone are initiated by binding of T3 to its nuclear receptor. The biological activity of thyroid hormone in target cells is determined by the intracellular T3 concentration which depends on the circulating levels of T3 and its precursor T4, the activity of ...

Hypothyroidism is readily dealt with in pregnancy by ensuring optimal thyroxine replacement as early as possible - recent research suggests increasing the thyroxine by two extra days' dosage a week from the time pregnancy is confirmed is worthwhile (Alexander et al 2004).Hyperthyroidism in pregnancy is usually caused by molar pregnancy, gestational thyrotoxicosis (GT) or Graves' disease. GT affects 1-3% of pregnancies and is 3 times more common in Asian ...

Adrenocortical insufficiency is a life-threatening hormonal deficiency which is readily treatable, but which commonly presents with longstanding, vague symptomatology. ACTH deficiency (the most common cause) requires only glucocorticoid replacement while patients with Addison's disease are also deficient in aldosterone and require fludrocortisone replacement.Hydrocortisone is the standard form of glucocorticoid replacement, and directly replaces the miss...

Low birth weight is associated with adult disorders characterised by insulin resistance such as type 2 diabetes, hypertension, dyslipidaemia and coronary heart disease. However the mechanism of this established association is still uncertain and controversial. For the past decade research has principally focused on the role of the intra-uterine environment. It has been proposed that under nutrition in utero results in a permanent re-programming of the fetal metabolism. Genetic...

One of the major current challenges in molecular genetics is the identification of genes underlying common, genetically complex diseases. The human genome sequence, and that of several model organisms, is now available and tools are available to measure in a single experiment the expression of every gene in these genomes. These resources offer unprecedented opportunities for disease gene identification. We have combined a classical genome screen approach, which localises disea...