Endocrine Abstracts

A 42 year old lady was referred to the endocrine clinic with a five month history suggestive of hypothyroidism and a high TSH and low T4 levels. Clinical examination revealed increased skin pigmentation, low systemic blood pressure, bilateral axillary lymphadenopathy and hepatosplenomegaly. Short synacthen test confirmed cortisol insuffiency and she was started on thyroxine and hydrocortisone, and went on to have further investigations for the lymphadenopathy and hepatosplenom...

Macroprolactin, a circulating complex of monomeric prolactin together with an autoantibody, is commonly encountered in the course of endocrine investigations. It is generally agreed macroprolactin exhibits reduced bioactivity in vivo since individuals who harbour the complex do not demonstrate the classic clinical signs or symptoms characteristic of true hyperprolactinaemia. The aim of this study was to compare the relative potency of purified preparations of macroprolactin to...

Where screening for macroprolactin takes place, laboratories routinely rely on treatment of sera with polyethylene glycol (PEG) to distinguish macroprolactinaemia from true hyperprolactinaemia. However, PEG is incompatible with a number of common immunoassay platforms. The aim of this study was to assess the specificity and clinical utility of ultrafiltration as an alternative procedure for removal of bio-inactive prolactin IgG complexes such as macroprolactin from serum prior...

Pre-operative localization of parathyroid adenoma using parathyroid imaging remains a controversial issue. However, with the advent of minimally invasive parathyroid surgery and the use of more sensitive radionuclide (Technetium Seastamibi and recently Technetium tetrofosmin); the belief in the usefulness of parathyroid imaging is increasing.Our objectives were a) to compare the sensitivities of three parathyroid imaging modalities (Thallium Substraction, Low Dose and High Dos...

Macroprolactin has reduced bioactivity and accumulates in the sera of some subjects, resulting in apparent hyperprolactinaemia. Development of the polyethyleneglycol (PEG) precipitation technique has enabled large-scale screening for macroprolactin in hyperprolactinaemic subjects. We have reviewed the experience of routine screening for macroprolactin using PEG precipitation over a 54-month period in a single centre.Plasma levels of prolactin exceeded 50...

Familial hypopituitarism is a heterogeneous group of disorders with variable clinical, biochemical and genetic characteristics. X-linked forms have been described in rare kindreds, though clinical and molecular features are not well defined. We present a case of X-linked hypopituitarism in a young male.The patient, currently 39 years, had an early course complicated by neonatal jaundice, seizures and subsequent failure to thrive. Hypothyroidism was diagn...

Prolactinomas are the most common secreting pituitary tumors. Although most respond well to dopamine agonists, some prolactinomas are dopamine-resistant and very aggressive. Here we present a 37-year-old patient with aggressive prolactinoma.Case report: The 37-year-old patient was referred to the University Hospital Centre Zagreb in March 2020 for bilateral visual field defects and headaches due to prolactinoma. In 2017, he had a transsphenoidal resectio...

Issues: Adolescent diabetes social stigma in India. Such diabetics needs proper guidance/information/treatment-counselling outlets. This is burning issue in developing-nations like India. Hence we all need to unite & form a comprehensive diabetes care & counselling policy plan at ECE conference. Treatment options must be suitable for developing-nations considering cost of Rx. Incorporating NGO’s in such efforts is very effective.Our Project ...

Background: Type 2 Diabetes (T2DM), though a rare condition in children, is increasing in the paediatric population. The British Paediatric Surveillance Unit (BPSU) reporting framework is used to understand the clinical course and epidemiology of rare diseases in children.Aim: To estimate the UK incidence of Type 2 diabetes (T2DM) in children aged <17 years and to compare with data collected a decade before. To characterize clinical features at diagn...

We report a 42-year-old female who was known to have autoimmune hypothyroidism for nearly 20 years with positive antiTPO antibodies. She was well controlled on levothyroxine including three antenatal periods when she required a slightly higher dose of 125 mcg daily. No significant past medical history and denies use of herbal/over the counter medications. In early 2017, the patient started to experience nonspecific symptoms of lethargy and tiredness. Her thyroid state was mana...