Endocrine Abstracts

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism between the age 50–65 years (55.00 (50.00; 58.00)) were treated with a 1% testosterone gel within 12 months.Results: Testosterone levels increased from 4.65 (2.70; 6.10) nmol/l at baseline to 13.65 (12.60; 15.20) nmol/l after 48 weeks of treatment (...

Recently, many cases with hypoglycemia who take oral hypoglycemic agents and/or insulin therapy are carried to the emergency room in our hospital due to hypoglycemia. Pharmacotherapy for patients with diabetes mellitus occasionally can causes severe hypoglycemic attack. In this study, we investigated 69 type 2 diabetics on clinical features (26 outpatients of our hospital, 43 outpatients of other clinics) among 100 patients who were carried to the emergency room due to hypogly...

Tc- 99m Sestamibi parathyroid scan (SP scan) is performed to identify location of either hyperplastic or adenomatous gland(s) in primary hyperparathyroidism (HPT). In this study we evaluated diagnostic outcome in 55 consecutive patients with clinical diagnosis of HPT who were referred for SP scans and subsequently had parathyroid surgery. These patients with HPT were of 66.9+12.46 (mean + SD) age, and had serum calcium 10.9+0.93 mg/dl, phosphorus 3.0+0.51 mg/dl, chloride 107+3...

Background: Chromogranin A (CgA) is essential for the formation of secretory granules and sequestration of hormones in neuroendocrine cells. Measurement of CgA levels is included in the diagnostic procedure of neuroendocrine tumors and pheochromocytoma. The aim of this study was to assess the reliability of the Kryptor assay for CgA measurement.Methods: Imprecision of the Kryptor CgA assay was determined with two levels of CgA concentration. Reference va...

Background: A number of studies have evaluated the association between prolactin (PRL) and breast cancer risk, but some results have been inconsistent.The aim of this study was to investigate, if the circadian rhythm of PRL was maintained in pre- and post-menopausal patients with breast cancer and if there is a correlation between serum PRL level, serum concentration of insulin-like growth factor 1 (IGF1), tumor staging and expression of estrogen, proges...

Purpose: For vaginoplasty of Rokitansky syndrome, we use oxidized regenerated cellulose instead of bio-craft that has been used in the past because it requires a less invasive and more physiological surgery. However, the mechanism of epithelialization of this procedure is still not clear. There is a report that differentiation and proliferation of the vaginal epithelium of newborn mice is promoted by administration of basic fibroblast growth factor (bFGF).<p class="abstext...

Introduction: Transsphenoidal surgery (TSS) is the treatment option of first choice for Cushing’s disease (CD). The traditional microsurgical technique has recently been challenged by endoscopic surgical methods. We present endocrine outcome of TSS in CD with a modified contemporary microsurgical concept.Methods: Eighty three patients underwent TSS for newly-diagnosed CD (72 microadenomas and 11 macroadenomas). An enlarged resection was performed in...

Obesity and associated insulin resistance are associated with increased numbers of infiltrating macrophages at various sites of white adipose tissue. The adipose tissue macrophages are considered to be a major cause of obesity-associated chronic low-grade inflammation. The macrophages present in adipose tissue secrete a wide variety of proinflammatory molecules including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1)...

Low endogenous testosterone levels in men have been associated with a more adverse cardiovascular disease risk factor profile including lower HDL-cholesterol and higher blood glucose levels, and increased risk of cardiovascular disease. However, it is uncertain whether low testosterone levels may precede disease onset, or are a result of preexisting disease. Prospective studies may help clarify this relationship.The EPIC Norfolk study reported that in 11...

Background: Numerous studies have provided evidence of the link between low testosterone levels and obesity, cardiovascular disease and type 2 diabetes. A recent UK study revealed 20% of type 2 diabetics had testosterone levels <8 nmol/l and 31% between 8 and 12 nmol/l. Hypogonadism in men can present with a variety of clinical symptoms which could include erectile dysfunction (ED). However, diabetic patients infrequently volunteer information regarding ED and is often not...