Searchable abstracts of presentations at key conferences in endocrinology

ea0077p186 | Metabolism, Obesity and Diabetes | SFEBES2021

Predictors of adverse outcomes in COVID-19: A retrospective cohort study comparing the first two waves of COVID-19 hospital admissions in London, with a focus on diabetes

Hashmi Durreshahwar , Shaikhali Yusuf , Cassin-Scott Rebecca , Eng Pei , Distaso Walter , Tan Tricia , Salem Victoria , Izzy-Engbeaya Chioma

Introduction: Diabetes has been associated with poorer outcomes with COVID-19 infection, but precise predictors of mortality in patients with diabetes remain unclear. We assessed predictors of adverse outcomes in patients hospitalised with COVID-19 in Imperial College Healthcare NHS Trust (ICHNT) hospitals during the first and second waves of COVID-19 to determine if outcomes for patients with diabetes have evolved with new variants and treatments.Method...

ea0068p36 | Abstracts | UKINETS2019

Two case reports of preserved endocrine and exocrine function in VHL patients with extensive pancreatic cysts

El Sayed Ahmed , Boharoon Hessa , Alsafi Ali , Preitner Nadia , Kosicka-Slawinska Monika , Brady Angela , Hill Peter , Tan Tricia

Von Hippel-Lindau (VHL) disease is an inherited tumour syndrome, caused by a mutation in the VHL tumour suppressor gene encoding the VHL protein. Patients are prone to cysts and neuroendocrine tumours in the pancreas and other benign and malignant neoplasms. Pancreatic cysts occur in approximately 70% of VHL patients. We describe two cases of VHL disease with extensive multi-cystic changes affecting the whole pancreas, both patients had deletions of exon 2–3 of the VHL ge...

ea0048oc1 | Oral Communications | SFEEU2017

Which test should the bariatric physician use to test for postprandial hypoglycaemia – prolonged oral glucose tolerance test versus mixed meal test?

Tharakan George , Behary Preeshila , Al-Najim Werd , Chahal Harvinder , Miras Alexander , Ahmed Ahmed , Bloom Stephen , Tan Tricia

Background: An increasingly recognized complication of Roux-en-Y Gastric Bypass (RYGB) surgery is the development of postprandial hypoglycaemia (PPH). However, there remains no agreed standard on how to diagnose this condition. Commonly used tests include a prolonged oral glucose tolerance test (POGTT) and mixed meal tolerance test (MMTT). Little is known regarding how these tests compare in the post-bariatric population.Methods: Ten patients who had con...

ea0021p118 | Clinical practice/governance and case reports | SFEBES2009

Salivary cortisol is a reliable marker to monitor hydrocortisone replacement

Pahilwani Bharat , Darch Sarah , Ramachandran Radha , Cegla Jaimini , Nijher Monica , Meeran Karim , Chapman Richard , Donaldson Mandy , Tan Tricia

Context: Hydrocortisone day curves (HCDC) are used to monitor hydrocortisone replacement by obtaining serum samples to measure cortisol levels throughout the day. Salivary measurement of free cortisol offers a non-invasive alternative to serum measurements.Objective: To validate salivary cortisol measurement as an alternative method to assess the adequacy of hydrocortisone replacement in patients with hypoadrenalism.Setting, patien...

ea0018oc1 | (1) | MES2008

Bilateral adrenalectomy in a patient with congenital adrenal hyperplasia

Chaudhri Owais , Hatfield Emma , Wynne Katie , Palazzo Fausto , Mehta Sanjeev , Shaikh Humera , Tan Tricia , Martin Niamh , Meeran Karim

We present the case of a 33-year-old woman diagnosed with congenital adrenal hyperplasia (CAH) due to classical 21-hydroxylase deficiency following a salt-losing crisis as a newborn. She had previously been controlled on dexamethasone 0.25 mg bd and fludrocortisone 100 mcg od, as evidenced by high-normal 17-hydroxyprogesterone (17-OHP) and low-normal testosterone levels (8.5 and 0.4 nmol/l respectively).However, she had experienced significant symptoms o...

ea0018oc4 | (1) | MES2008

MEN1: the full house

McGowan Barbara , Fountain Annabel , Chaudhri Owais , Mehta Puja , Tan Tricia , Hatfield Emma , Martin Niamh , Todd Jeannie , Meeran Karim

This gentleman was diagnosed with hyperparathyroidism at the age of 34 and was found to have multiple manifestations of MEN1.Hyperparathyroidism: He was diagnosed with hyperparathyroidism and underwent a parathyroidectomy with removal of 2 glands. Four years later calcium levels were raised once again and two further hyperplastic glands were removed, with cure of his hypercalcaemia.Gastrinoma and other pancreatic islet cell tumours...

ea0077p82 | Neuroendocrinology and Pituitary | SFEBES2021

Pituitary and gonadal axes in patients with ‘Long COVID’: post hoc analysis

Clarke Sophie , Phylactou Maria , Patel Bijal , Mills Edouard , Muzi Beatrice , Izzi-Engbeaya Chioma , Choudhury Sirazum , Khoo Bernard , Meeran Karim , Comninos Alexander , Abbara Ali , Tan Tricia , Dhillo Waljit

Background: It is apparent that COVID-19 may cause persistent symptoms beyond 12 weeks (‘long COVID’). However its underlying pathophysiology is unclear. Several symptoms of long COVID draw similarities to that of endocrine diagnoses. We recently observed that adrenal and thyroid function were normal in survivors of COVID-19 at follow-up. Here we assess additional endocrine axes that could plausibly have a role in long COVID to determine their relationship to ongoing...

ea0053cd2.1 | Case Discussions: complex clinical cases 2.0 | OU2018

Eating behaviour and psychological relationship to food following Roux-en-Y Gastric bypass surgery or VLCD intervention: insights into mechanisms of sustained weight loss

Alessimii Haya , Perez-Pevida Belen , Scholtz Samantha , Kenkre Julia , Doyle Chedie , Ahmed Ahmed , Purkayastha Sanjay , Miras Alexander D , Chahal Harvinder , Tan Tricia

Introduction/Aims: Currently, the most successful long term treatment for obesity is bariatric surgery, however the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following bariatric surgery. We aimed to investigate changes in eating behaviour and psychological factors pre- and 1 month post-very low calorie diet (VLCD) and 3-month p...

ea0053cd2.2 | Case Discussions: complex clinical cases 2.0 | OU2018

Poor responsiveness after bariatric surgery: clinical and eating behaviour characteristics

Perez-Pevida Belen , Aldhwayanand Madhawi , Gibson Rachel , Scholtz Samantha , Miras Alexander D , McGlone Emma , Kamocka Anna , Khan Omar , Greener Veronica , McGowan Barbara , Rubino Francesco , Bloom Steve , Tan Tricia

Background: Bariatric surgery has been proven to produce substantial weight loss and amelioration of metabolic syndrome-associated co-morbidities. However, at five-year follow-up, only 20–40% of patients maintain diabetes remission and 40% of patients return to their baseline weight. The limiting factor in treating refractory diabetes following obesity surgery is the lack of knowledge about its aetiology.Aims: Evaluate the eating pattern and clinica...

ea0053cd2.3 | Case Discussions: complex clinical cases 2.0 | OU2018

Surgical revision of candy cane after Roux-en-Y gastric bypass (RYGB)

Kamocka Anna , McGlone Emma Rose , Pevida Belen Perez , Purkayastha Sanjay , Moorthy Krishna , Hakky Sherif , Chahal Harvinder , Tsironis Christos , Miras Alexander , Tan Tricia , Ahmed Ahmed

Introduction: An excessively long blind-end of the alimentary limb following RYGB, known as a ‘candy cane’ (CC), may cause symptoms such as pain, gastrointestinal symptoms and weight regain. Very few studies have examined the efficacy of surgical resection of the CC. We aimed to assess symptom resolution following CC surgery.Methods: Single centre observational study of 28 CC revisions from 2010 to 2017 (mean age 45±8, female preponderance...