Searchable abstracts of presentations at key conferences in endocrinology

ea0032p274 | Clinical case reports - Thyroid / Others | ECE2013

Paraganglioma, germline nonsense mutation in succinate dehydrogenase B gene (R27X) and response to sunitinib

Elezovic Valentina , Petakov Milan , Ognjanovic Sanja , Macut Djuro , Isailovic Tatjana , Ilic Bojana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

A 36-years-old male with mild hypertension was diagnosed with pseudocystic tumor (67 mm) in pancreatic region and liver metastasis in April 2010. One month later, the extirpation of retroperitoneal mass and metastasis was performed in local medical centre. Pathohistological diagnosis was metastatic paraganglioma (Ki67, 3.5%). In June 2010, he was transferred to our Institution, and (131) I-metaiodobenzylguanidine (MIBG) scintigraphy was negative. However ((18) F) fluorodeoxygl...

ea0032p531 | Endocrine tumours and neoplasia | ECE2013

Long-term outcome after transarterial chemoembolization of hepatic metastases from neuroendocrine tumors

Ognjanovic Sanja , Petakov Milan , Isailovic Tatjana , Elezovic Valentina , Macut Djuro , Popovic Bojana , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Colic Momcilo , Damjanovic Svetozar

Introduction: Most patients with neuroendocrine tumors (NETs) present with liver involvement at the time of diagnosis. Trans-catheter arterial chemoembolization (TACE) is accepted treatment of patients with non-resectable hepatic metastases from NETs.Aim: To analyze objective tumor response and clinical outcome in patients with hepatic metastases from NETs who underwent TACE.Methods: Thirty-one patients underwent 140 TACE procedure...

ea0032p535 | Endocrine tumours and neoplasia | ECE2013

Adrenal lesions in patients with neuroendocrine tumors

Popovic Bojana , Macut Djuro , Petakov Milan , Bozic Ivana , Bogavac Tamara , Isailovic Tatjana , Ognjanovic Sanja , Elezovic Valentina , Micev Marjan , Menkovic Nemanja , Ilic Dusan , Damjanovic Svetozar

Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed accordin...

ea0032p587 | Female reproduction | ECE2013

The hypothalamo--pituitary--adrenal axis sensitivity in women with polycystic ovary syndrome

Ilic Dusan , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Damjanovic Svetozar

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

ea0032p602 | Female reproduction | ECE2013

Relation of adiponectin and leptin to antropometric and metabolic parameteres in women with polycystic ovaries syndrome

Bogavac Tamara , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Vojnovic Milutinovic Danijela , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

ea0032p893 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Myeloproliferative neoplasms in patients with acromegaly

Isailovic Tatjana , Beleslin Bojana , Lalic Nebojsa , Lukic Ljiljana , Popovic Bojana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Pekmezovic Tatjana , Damjanovic Svetozar

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

ea0014oc4.6 | Neuroendocriology basis | ECE2007

Metabolic abnormalities in patients with adrenal adenomas may be associated with BclI polymorphism in the glucocorticoid receptor (GR) gene and expression of tumor-specific hsp70 isoforms

Damjanovic Svetozar , Antic Jadranka , Beleslin Bojana , Ognjanovic Sanja , Vignjevic Jovana , Petakov Milan , Macut Djuro , Paunovic Ivan , Isailovic Tatjana , Popovic Bojana , Bozic Ivana

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...

ea0014p173 | (1) | ECE2007

Novel mutations in genes encoding succinate dehydrogenase complex subunits B (SDHB) and von Hippel-Lindau protein (VHL) in patients with nonsyndromic pheochromocytoma

Vignjevic Jovana , Nikolic Jelena , Isailovic Tatjana , Mirkovic Katarina , Petakov Milan , Antic Jadranka , Macut Djuro , Beleslin-Cokic Bojana , Popovic Bojana , Bozic Ivana , Ognjanovic Sanja , Damjanovic Svetozar

Background: Several susceptibility genes have been found to be associated with development of pheochromocytoma (PHEO): RET, VHL, SDHB and SDHD. We investigate the frequency of germ-line mutations in SDHB and VHL genes in patients with apparently sporadic PHEO.Material and methods: Fifty patients (38 women, mean age 42) with apparently sporadic adrenal and extra-adrenal PHEO were screened. DNA was extracted from whole blood and from paraffin embedded tumo...

ea0014p176 | (1) | ECE2007

Mutational analysis in patients with nonsyndromic MEN1

Mirkovic Katarina , Beleslin-Cokic Bojana , Vignjevic Jovana , Nikolic Jelena , Antic Jadranka , Popovic Bojana , Isailovic Tatjana , Bozic Ivana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Damjanovic Svetozar

Background: Mutational screening of the MEN1 gene has been recommended for patients who fulfill clinical criteria for familial or sporadic MEN1 and those suspicious or atypical of MEN1.Patients and methods: Eighteen apparently unrelated individuals (6 males; 12 females, age range 16–71) with clinical manifestations of MEN1 were analised. In addition, we evaluated 7 relatives. Genomic DNA from peripheral blood leucocytes was extracted using st...

ea0013p327 | Thyroid | SFEBES2007

RET proto-oncogene exon 11 germline mutations in patients with medullary thyroid carcinoma

Petakov Milan , Nikolic Jelena , Katarina Mirkovic , Jadranka Antic , Jovana Vignjevic , Bojana Beleslin-Cokic , Tatjana Isailovic , Sanja Ognjanovic , Djuro Macut , Svetozar Damjanovic

Several RET proto-oncogene germline mutations with dominant inheritance, predispose to hereditary medullary thyroid carcinoma (MTC), and whether the MTC is sporadic or hereditary should be determined by a direct analysis of the RET proto-oncogene. 85% of MEN IIA patients and 30% of patients with familial medullary thyroid carcinoma have mutations at codon 634 (exon 11). In 88 consecutive patients with MTC, the characterization of RET mutations in exon 11 had been done by PCR w...