Endocrine Abstracts

Introduction: Determining the radiation dose to both the kidneys and malignant lesions from therapeutic administrations of Y-90 DOTATOC is critical for optimal management of neuroendocrine cancer patients. Here, a new dosimetric approach uses PET/CT to quantify the absolute activity of Y-90 immediately after administration to calibrate subsequent tissue clearance monitored with bremsstrahlung SPECT. The dosimetric information is used to personalize subsequent Y-90 DOTATOC dose...

Perturbations in thyroid function are common in older individuals but their significance in the very old is not fully understood. We examined thyroid hormone status (serum TSH, FT4, FT3, rT3) at baseline in a cohort of 643 85-year-olds and followed their mortality and disability outcomes for 9 years. All cause mortality, cardiovascular mortality and disability according to categorical thyroid disease status and baseline thyroid hormone paramete...

The glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor (GPCR) expressed in various tissues such as brain and pancreas where it contributes to the regulation of energy expenditure and metabolism. Due to its involvement in glucose-dependent release of insulin from pancreatic beta cells, the GLP-1R has become a blockbuster target for the treatment of type 2 diabetes. Despite this, debate still exists about the exact distribution of the GLP-1R throughout the...

Background: Current guidelines recommend regular monitoring of total testosterone, haematocrit and prostate-specific antigen (PSA) when androgen-deficient males are commenced on testosterone replacement therapy (TRT). The aim is to restore serum total testosterone to the mid-normal range, whilst maintaining haematocrit and PSA at the recommended levels. Limited studies have assessed the impact of ethnicity on these biochemical parameters.Aim: To measure ...

Aims: Studies have suggested that breath gases, including acetone, may be related to simultaneous blood glucose (BG) and blood ketone levels in adults with types 2 and 1 diabetes. We aimed to study these relationships in children and young people with type 1 diabetes to assess the efficacy of a simple breath test as a non-invasive means of diabetes monitoring.Methods: Gases were collected in breath bags and measurements were compared with capillary BG an...

Background: Data concerning pubertal development and testosterone (T) in obese male adolescents (ObA) are scarce and contrasting. Underperforming T immunoassays and poor assessment of pubertal development might explain discordant findings. Although SHBG is markedly affected, few studies report free T (FT) levels.Objective: To study if ObA have conserved FT levels despite low total T (TT) and to investigate if FT is a better indicator of androgen exposure...

Successful minimally invasive parathyroidectomy for primary hyperparathyroidism depends on accuracy of pre-operative localisation studies. Ultrasound (US) and sestimibi (SM) scanning remain the imaging modalities of choice reserving MRI, CT and PET for patients who have not been cured by previous explorations or for whom other localization techniques are uninformative or discordant. The aim of this study was to review the accuracy of US and SM in the pre-operative localisation...

Introduction: Although it is well-known that serum testosterone (T) levels decrease in ageing men, to this date no longitudinal data are available on changes in T levels in healthy young adult men.Objective: To investigate age-related longitudinal changes in serum levels of total T, free T and sex hormone binding globulin (SHBG) in healthy young men.Methods: Data from 999 healthy men aged 24–46years who participated in a long...

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...

Aim: Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance imaging (MRI) based method to identify human BAT and delineate it from white adipose tissue (WAT), and validate it by providing immunohistochemical confirmation.Methods: Initial scanning with 18F-FDG PET–CT radiotracer uptake on a 25-year-old Caucasian female wit...