Searchable abstracts of presentations at key conferences in endocrinology

ea0050p183 | Clinical Biochemistry | SFEBES2017

The free androgen index in women is inaccurate when the SHBG concentration is low

Keevil Brian , Adaway Joanne , Fiers Tom , Kaufman Jean-Marc

Introduction: Current clinical practice guidelines recognise that a calculated free testosterone (T) level is the single most-useful, clinically sensitive marker of androgen excess in women, but there is no clear guidance as to the best way to measure free T. Several equations have been proposed to calculate clinically useful estimates of free T including the free androgen index (FAI) and calculated free T (cFT). The FAI is not used in men but it is...

ea0050ep054 | Diabetes and Cardiovascular | SFEBES2017

Significant improvement in response to the GLP1-agonist 'Liraglutide' following change in injection site

Border Daniel , Clayton Wendy , Barber Tom , Randeva Harpal

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

ea0086op5.4 | Bone and Calcium | SFEBES2022

Prospective clinical trial of a novel, reusable, pocket size Point of Care device to measure ionized calcium in venous and capillary blood and saliva

Rozalen Garcia Virginia , Abdel Aziz Tarek , Soromani Christina , Kurzawinski Tom

Background: Patients with hypoparathyroidism require frequent calcium measurements and currently there is no point of care device allowing this to be done at home by patients themselves. The aim of our study was to evaluate whether ionized calcium(iCa) can be accurately measured in venous and capillary blood and saliva by a repurposed device LAQUA.(R&D Ref 18/0058– IRAS 236079)Methods: Patients undergoing thyroid and parathyroid surgery underwen...

ea0086p200 | Metabolism, Obesity and Diabetes | SFEBES2022

The American lifestyle-induced obesity syndrome diet (ALIOS) in mice alters the diversity and composition of the gut microbiome

Potter Tom , Arvaniti Anastasia , Harris Shelley , Tomlinson Jeremy , Gathercole Laura

Dysbiosis of the gut microbiome contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Reduced diversity and composition of the microbiome are associated with increased intestinal barrier permeability, increased bacterial translocation and NAFLD progression. The ALIOS diet in rodents replicates many of the metabolic and histological features of NAFLD in humans and here we report the effect of the ALIOS diet on the gut microbiome. Male and female C57BL/6 ...

ea0038p63 | Clinical practice/governance and case reports | SFEBES2015

A case to remember

Rahman Mohammad , Obuobie Kofi , Hickin Tom , Hamdan Khaliq

Introduction: X-linked adrenoleucodystrophy (XALD) is a progressive disorder affecting adrenal glands, testis, and myelin stability, that normally caused by mutations in ABCD1 (NM_000033) gene There is a failure of β-oxidation of fatty acids within peroxisomes due to reduced activity of very long chain acyl-CoA synthetase and can be diagnosed by the demonstration of elevated very long chain fatty acid.Case report: We report a case of a 32-y...

ea0037ep338 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Pancreatogenic diabetes

Yahia Seif eldin , Mendis Budd , Crabtree Tom , Seevaratnam Nandini

Aims: Diabetes mellitus secondary to pancreatic disease and pancreatic surgery (pancreatogenic; type 3c) is a discrete entity to common types of diabetes and there are no well established guidelines for its management. At Nottingham University Hospitals, we have set up a multidisciplinary pancreatogenic diabetes clinic since 2008. The aim of this study is to look at the outcome of the clinic since it’s been established.Methods: Case notes and hospit...

ea0037ep397 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Targeting optimal metabolic parameters in type 1 diabetes and concomitant coeliac disease: an extra challenge

Kiat Clifford , Cotter Tom , Dinneen Sean , O'Sullivan Esther

Patients, especially children, with type 1 diabetes (T1D) have an increased risk of developing other autoimmune disorders including coeliac disease (CD). While the general population prevalence of CD is ~1%, in patients with T1DM the prevalence of CD is higher (0.6–16%). Gluten free diet (GFD) imposes limitations in dietary options. Many of the gluten-free foods have a high glycemic index. This can influence glycemic values and metabolic parameters. We selected the subgro...

ea0037ep838 | Thyroid cancer | ECE2015

Well-differentiated thyroid cancer: the Philippine General Hospital experience

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

Well-differentiated thyroid carcinoma (WDTC) is the most common thyroid malignancy. Although, associated with good prognosis, it may have a highly recurrent and fatal outcome in selected groups of patients. Filipinos in particular were reported to be the ethnic group with the highest incidence of thyroid cancer in several studies. Thyroid cancer among Filipinos were also observed to be more aggressive and recurrent in nature. This paper aims to describe the experience of a Phi...

ea0037ep839 | Thyroid cancer | ECE2015

Risk factors for recurrence in Filipinos with well-differentiated thyroid cancer

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

The incidence of recurrent well-differentiated thyroid cancer (WDTC) continues to rise as better imaging test and more sensitive monitoring improves disease surveillance. Despite its excellent prognosis, increasing morbidity from recurrent diseases continues to affect long-term outcome of most patients leading to higher medical cost and poorer quality of life. Filipino ethnicity in particular was reported to have the highest incidence of thyroid cancer with a highly aggressive...

ea0037ep840 | Thyroid cancer | ECE2015

Follicular variant of papillary thyroid carcinoma: an intermediate clinical entity

Lo Tom Edward , Uy Abigail , Maningat Patricia Deanna

Follicular variant papillary thyroid cancer (FV-PTC) appeared to be the most common subtype representing between 9 and 22.5% of all PTC cases. With the dramatic increase in thyroid cancer incidence, FV-PTC has also been increasingly diagnosed in recent times. Despite its high incidence, the clinical behaviour, prognosis and outcome of FV-PTC remains controversial and challenging for most physicians. This study aims to compare the disease characteristics of FV-PTC with Classic-...