Searchable abstracts of presentations at key conferences in endocrinology

ea0021p81 | Clinical practice/governance and case reports | SFEBES2009

Hypertension in familial adenomatous polyposis (FAP): don't be conn'd!

Hopkins Tom , Tan Tricia , Salem Victoria , Palazzo Fausto , Meeran Kareem

A 36-year-old man, presenting to his GP with severe intermittent headaches, was found to have a blood pressure of 210/110 mmHg. He had been diagnosed with familial adenomatous polyposis (FAP) in early childhood, and had had a total colectomy with ileo-rectal anastamosis at the age of 17. Routine surveillance CT imaging the following month revealed an incidental finding of bilateral adrenal masses (right 4×2 cm, left 2.7×2.9 cm).On assessment in...

ea0021p89 | Clinical practice/governance and case reports | SFEBES2009

Severe primary hyperparathyroidism (PHPT) and osteomalacia in pregnancy complicated by post parathyroidectomy hypocalcaemia related transient congestive cardiac failure (CCF): a case report

Thorogood Natasha , Kurzawinski Tom , Conway Gerard , Baldeweg Stephanie

Introduction: PHPT is reported to be rare in pregnancy, with 150 cases described in the literature. Its incidence is 8/100 000 in childbearing women/year. PHPT may lead to a loss of up to 50% of pregnancies through miscarriage or stillbirth, dehydration, hyperemesis, nephrolithiasis, pre-eclampsia, fractures and pancreatitis in mothers; and death, hypocalcaemia and tetany in neonates. Intrauterine growth retardation, low birth weight and pre-term labour were described. Rate of...

ea0021p215 | Endocrine tumours and neoplasia | SFEBES2009

Receptor-based scintigraphic imaging of insulinoma and glucagonoma in MEN-1

Sivappriyan Sivasubramaniam , Kurzawinski Tom , Bomanji Jamshed , Conway Gerard , Ahlquist James

Successful surgery for pancreatic neuro-endocrine tumours (NET) requires accurate tumour localisation. Interpretation of cross-sectional imaging is often difficult, particularly after pancreatic surgery. Imaging by somatostatin-receptor-scintigraphy with indium-labelled octreotide may be useful in identifying recurrent disease; however, octreotide scans may be negative in some pancreatic NET, due to a low level of expression of somatostatin receptors. The GLP-1 receptor is abu...

ea0013p323 | Thyroid | SFEBES2007

The unrecognised use of alternative treatments for thyroid disorders

Hutchinson Maeve E , Shea Donal O’ , Cawood Tom J

Alternative treatments for thyroid disorders include animal thyroid extract and preparations containing iodine. These treatments can affect thyroid status and their use may be unrecognised by doctors treating patients with thyroid disorders. We aimed to determine the nature, availability and use of alternative treatments for thyroid disorders (ATTDs).Patient questionnaires were administered to all patients with a diagnosis of a thyroid disorder attending...

ea0045oc8.6 | Oral Communications 8- Diabetes | BSPED2016

Is abuse associated with adolescent overweight and obesity?: A population cohort study

Hawton Katherine , Norris Tom , Crawley Esther , Hamilton-Shield Julian

Background and Objectives: Abuse in childhood is associated with obesity in adult life. However, little is known about the relationship between abuse and obesity during childhood or adolescence. The aim of this study was to investigate, using a birth cohort study, whether there was an association between pre-adolescent child abuse and overweight and obesity in later childhood. We hypothesised that abuse and obesity may be associated.Methods: Using data f...

ea0095p61 | Obesity 1 | BSPED2023

The use of cardiopulmonary exercise testing (CPET) for assessment and guiding interventions in adolescents with obesity

Larcombe Thomas , Davis Nikki , Meredith Tom , Connett Gary

Introduction: Paediatric obesity is increasing globally. By 2050, obesity is expected to cost the UK NHS £10 billion annually.1 Physical activity and exercise are recognised interventions to reduce BMI.2 However, the physiological response to exercise is not understood. Understanding physiological responses in people with obesity (PwO) can inform the prescription of safe rehabilitation exercise programmes. This pilot study explored t...

ea0077p107 | Reproductive Endocrinology | SFEBES2021

A randomised controlled trial on the effect of very-low-calorie diet (VLCD) vs. an energy deficit diet, in women with the polycystic ovary syndrome (PCOS) – remission PCOS

Deshmukh Harshal , Papageorgiou Maria , Wells Liz , Akbar Shahzad , Strudwick Tom , Reid Marie , Sathyapalan Thozhukat

PCOS is the most common endocrine disorder affecting the women of reproductive age group and weight loss is the mainstay of management of PCOS. We performed an open-label randomised controlled trial to compare the effects of a conventional energy deficit approach (-600 kcal/day of the total energy requirements) vs. a very low-calorie diet (VLCD: 800 kcal/day) on free androgen index (FAI), body weight, and metabolic markers in women with PCOS. Forty-one eligible patients were r...

ea0081p370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Differential localisation of the A-ring reductases in human hepatocytes: implications for substrate preference and utilisation

Potter Tom , da Conceicao Ismael , Nikolaou Nikolaos , Loh Nellie , Tomlinson Jeremy , Gathercole Laura

The 5-reductases are steroid metabolising enzymes that saturate the C4=C5 bond of the steroid A-ring, and their substrates include androgens, glucocorticoids, and bile acids. 5β-reductases (SRD5A1 & SRD5A2) convert testosterone to the more potent androgen 5β-dihydrotestosterone, and carry out the first step in glucocorticoid clearance, generating 5β-dihydrocortisol from cortisol. 5β-reductase (AKR1D1) is also able to carry out the first step of glucocor...

ea0050oc1.2 | Early Career Oral Communications | SFEBES2017

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids

Marjot Tom , Othonos Nantia , Woods Conor , Hazlehurst Jonathan , Moolla Ahmad , Hodson Leanne , Tomlinson Jeremy

Glucocorticoids (GC) are commonly prescribed and their use is associated with adverse metabolic side effects. 5a-reductase (5aR) inhibitors are also frequently prescribed mainly for their ability to inhibit the conversion of testosterone to dihydrotestosterone. However, they also have a role to inactivate and clear GCs. We hypothesised that 5aR inhibitors have the potential to exacerbate the adverse metabolic effects of GCs. We conducted a prospective, randomised, study in 19 ...

ea0050p206 | Diabetes and Cardiovascular | SFEBES2017

The impact of a dedicated metabolic hepatology clinic for the treatment of non-alcoholic fatty liver disease

Motohashi Kenzo , Moolla Ahmad , Marjot Tom , Ainsworth Mark , Tomlinson Jeremy , Cobbold Jeremy

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is tightly associated with insulin resistance and type 2 diabetes (T2DM), both risk factors for disease progression, liver failure and cardiovascular complications. A multidisciplinary approach involving hepatologists and diabetologists working alongside allied health professionals is thus advocated for the management of NAFLD. Interv...