Endocrine Abstracts

Objectives: This study aimed to assess the ability of aldosterone in saline infusion test (SIT) to predict biochemical remission of primary aldosteronism.Methods: We retrospectively analysed 42 patients (19 (45%) females, mean age 49±12 years) with primary aldosteronism who underwent adrenalectomy (after adrenal vein sampling confirmation of unilateral disease) from 2017 to 2022. Aldosterone in SIT was determined on the fifth postoperative day, as wel...

Background: Adrenal venous sampling (AVS) is considered the gold standard for differentiating an aldosterone- producing adenoma (aPA) from bilateral adrenal hyperplasia (BAH)Objective: The aim of this study is to present our experience with this method in our hospital.Methods: We performed a retrospective analysis of 105 patients who underwent the AVS protocol at our centre between 2015 and 2022 for PA.Result...

Background: Adrenal venous sampling (AVS) is the gold standard to differentiate patients with unilateral primary aldosteronism (UPA) from those with bilateral disease (BPA). As this is an invasive method, there are a lot of different scoring systems developed for primary aldosteronism (PA) subtyping. Integer scoring system is one of those established for BPA subtyping.Objective: The aim of this study was to evaluate the efficiency of using the online Int...

A genome wide meta-analysis by the CORtisol NETwork (CORNET) consortium1 has identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with changes in morning plasma cortisol and predictive of cardiovascular disease (Crawford et al, Unpublished). SERPINA6 encodes Corticosteroid Binding Globin (CBG) which binds most cortisol in blood and influences delivery of cortisol to target tissues. We hypothesised th...

Background: Gigantism is a rare condition with accelerated growth in childhood when the epiphyseal plates are not fused. Most cases are due to growth hormone (GH) secretion from a pituitary adenoma. Rarer causes of GH-related gigantism include somatotroph hyperplasia as part of McCune-Albright syndrome, Carney complex, X-linked acrogigantism or ectopic GHRH production.Case presentation: An 18-year-old male with c.249_252delGTCT;p.I85Sfs MEN1 mut...

Introduction: Glucocorticoids (GC) are prescribed to 2–3% of the population of the UK and USA. Their use is associated with a significant side effect profile that includes the development of central obesity, insulin resistance and type 2 diabetes. 5α-reductase (5αR) inhibitors (Finasteride and Dutasteride) are also commonly prescribed in the context of prostate disease, where they inhibit the conversion of testosterone to dihydrotestosterone. Additionally, they ...

Recent data suggest that not only caloric density but also macronutrient composition of diets can influence metabolism, body composition and the development of metabolic disorders. A limitation of previous studies was that effects were studied predominantly in males. To better understand potential differences in the response of males and females to manipulations of dietary macronutrients, our studies were undertaken in both sexes. As a dietary model, we used regular chow diet ...

Background: Patients taking corticosteroids for immune suppression are vulnerable to adrenal crisis during intercurrent illness or if steroids are stopped abruptly. Although patients on glucocorticoids for adrenal failure are routinely provided with sick day rules, we wished to ascertain whether patients on immunosuppressive steroids are appropriately counselled.Aim: This study sets out to compare patient awareness of steroid sick day rules in endocrine ...

Diabetes mellitus is currently being recognised as a global health problem. The likelihood of periodontal disease among diabetics is thrice and progresses rapidly when uncontrolled. Diabetics were less likely to see a dentist than to seek consult with a doctor for diabetes care. A cheap and easy way of clinical assessment via self-reported oral health questionnaire would be of great use especially in a developing country like The Philippines. This study aims to validate self-r...

Introduction: Giant prolactinomas are rare pituitary tumours. They can present with visual field defect, intracranial pressure symptoms and even temporal lobe epilepsy. Impairment of higher cognitive functions has been reported postoperatively after trans-cranial surgery and following radiotherapy. Reversible cognitive disturbances have been previously reported in patients with surgically decompressed arachnoid cysts but not after medical treatment of giant prolactinoma. We pr...