Endocrine Abstracts

Background: Secondary hyperparathyroidism (SHPT) is common in obesity, and a concern after obesity surgery due to negative impact on bone. Longitudinal data is sparse, and relationships with vitamin D and calcium levels are unclear. We studied the prevalence of SHPT over five years after Roux-en-Y gastric bypass (RYGB) and investigated whether SHPT was associated with serum levels of 25-hydroxyvitamin D (25(OH)D) and ionized calcium (iCa).Methods: 347 of...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is tightly associated with type 2 diabetes (T2DM), the principal risk factor for disease progression, liver failure and cardiovascular complications. At present there are no licensed therapies and management aims to optimise metabolic risk factors through weight loss, and pharmacological interventions for diabetes and cardiovascular disease. A multidisciplinary approa...

Background: Although adrenal vein sampling (AVS) is a technically demanding procedure, it is still considered the gold standard for subtyping primary aldosteronism (PA). The aim of the study was to analyze the success rate of AVS in patients with PA.Methods: In all patients AVS was performed sequentially during continuous stimulation with adrenocorticotrophic hormone by one interventional radiologist. Adrenal vein cannulation was considered successful if...

Background: Pituitary apoplexy is a rare complication of pituitary adenomas, especially nonfunctioning tumors. It is associated with severe headache, which may be accompanied by visual disturbances or ocular palsy. Here we present two patients who suffered from pituitary adenoma apoplexy while receiving anticoagulation therapy with non-vitamin K antagonists.Case presentation: A 74-year old woman was diagnosed with a non-functioning pituitary macroadenoma...

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Aim of this audit was to assess clinical, biochemical parameters, localisation modalities and outcome in patients undergoing parathyroidectomy at University College London Hospital (UCLH).Methods: We audited all patients aged 15-years or above, undergoing parathyroidectomy, from 01-02-2018 to 31-12-2021 at UCLH via retrospective data collectio...

Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders affecting 6-15% of women of reproductive age. The syndrome is characterised by a variety of reproductive and metabolic features, including hyperandrogenism, chronic anovulation and hirsutism as well as insulin resistance, dyslipidaemia, and non-alcoholic fatty liver disease (NAFLD). Specifically regarding NAFLD, androgen excess is hypothesised to have a direct effect on hepatic lipid storage, thus...

Bile acids and steroid hormones are potent regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in the liver where it catalyses a fundamental step in bile acid synthesis and inactivates steroid hormones. We have previously shown that male, but not female, AKR1D1 knockout (KO) mice on a normal chow diet are leaner than wildtype littermates but are not protected against diet induced obesity. Here we investigate the impact of a high fat diet on female...

Pituitary metastases are reportedly uncommon. Here we report two cases illustrating metastases responding to systemic anticancer therapy (SACT). A 49-year-old woman with metastatic renal cell carcinoma treated with combination ipilimumab and nivolumab immunotherapy was referred for hypocortisolaemia (morning cortisol 74 nmol/l). Biochemical screening revealed an adrenocorticotropic hormone of 16ng/l (0-46), thyroid-stimulating-hormone 0.1mU/l (0.55-4.78), free thyroxine 7 pmol...

Aim: We describe the natural history, treatment, and clinical outcomes of Multiple Endocrine Neoplasia type 2B (MEN2B) caused by the M918T RET pathogenic variant.Methods: Retrospective case notes review of all young people <18 years presenting to a quaternary paediatric endocrinology referral centre in the UK between 2005-2023 who have MEN2B caused by the M918T pathogenic variant in the RET proto-oncogene.<p clas...

Objective: To investigate performance of sex hormone binding globulin (SHBG) assays of different manufacturers and the effects of assay choice on calculated free testosterone (cFT).Methods: Anonymized serum samples of 113 men and 106 women were randomly selected from excess material from the routine clinical lab at the University Hospital of South Manchester. SHBG levels were measured using three different immunoassays (...