Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep209 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Turner’s syndrome and liver involvement: prevalence and characterization of a large population with Turner’s syndrome

Calanchini Matilde , Moolla Ahmad , Tomlinson Jeremy W , Cobbold Jeremy , Fabbri Andrea , Grossman Ashley , Turner Helen

Introduction: Elevated liver function tests (↑LFTs) are frequent in Turner’s syndrome (TS), with a prevalence between 20 and 80%, and increases with age. Their pathogenesis and clinical significance is unclear.Objectives: To study the prevalence of ↑LFTs and their relationship with karyotype, anthropometric, metabolic and TS-related conditions: 68 TS women, average age 39 years (range 18–61 years), were reviewed.<p class="abstex...

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0059p136 | Neuroendocrinology and pituitary | SFEBES2018

Recovery of the hypothalamic-pituitary-adrenal and thyroid axes up to 12 months following trans-sphenoidal adenomectomy

Gunatilake Sonali , Pofi Riccardo , Macgregor Victoria , Cudlip Simon , Jafar-Mohammadi Bahram , Tomlinson Jeremy , Pal Aparna

Background: Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Recovery of pituitary function can occur, and reassessment is required to avoid unnecessary hormonal replacement. However, frequency of re-testing is variable across centres. Aim of this study was to determine recovery rates and time to recovery of hypothalamo-pituitary adrenal (HPA) and thyroid axis after TSA.Methods: We performed a single-centre, retrospecti...

ea0059p167 | Obesity &amp; metabolism | SFEBES2018

Male 5-beta reductase knockout mice have altered pancreatic islet morphology and hormone secretion

Harris Shelley , Gathercole Laura , Nikolaou Nikolaos , Ramracheya Reshma , Cox Roger , Forhead Alison , Tomlinson Jeremy

The enzyme 5β-reductase (AKR1D1) controls intra-cellular steroid hormone availability through hormone clearance. Additionally, it catalyses an essential step in bile acid (BA) synthesis. Disturbances in steroid hormones and BA metabolism have potent effects on metabolic health, therefore we hypothesize that AKR1D1 may play a role in metabolic homeostasis; the role of AKR1D1 in regulating glucose homeostasis and pancreatic function remains unexplored. We generated a global...

ea0038oc3.6 | Steroids and adrenal | SFEBES2015

Female 5β-reductase knockout mice are protected from diet induced obesity, insulin resistance, and glucose intolerance

Gathercole Laura , Chapman Matthew , Larner Dean , Klusonova Petra , Penning Trevor , Odermatt Alex , Lavery Gareth , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolic phenotype. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in me...

ea0038p228 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Characterising fat distribution and response to weight loss in idiopathic intracranial hypertension

Ali Fizzah , O'Reilly Michael , Botfield Hannah , Markey Keira , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Introduction: Idiopathic intracranial hypertension (IIH) occurs in young obese women (>90%) but little is known about the metabolic characteristics in these patients. We aimed to characterise IIH fat distribution, metabolic phenotype and evaluate alterations following weight loss.Methods: IIH and matched (BMI/sex) healthy obese controls were recruited. Metabolic indices (fasting lipid, glucose, insulin), anthropological measures and body composition ...

ea0037oc5.4 | Steroids, developmental and paediatric endocrinology | ECE2015

Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome

O'Reilly Michael , Kempegowda Punith , Gathercole Laura , Taylor Angela , Bujalska Iwona , Tomlinson Jeremy , Arlt Wiebke

Insulin resistance and androgen excess are the cardinal features of polycystic ovary syndrome (PCOS). The severity of hyperandrogenism and metabolic dysfunction in PCOS are closely correlated, but underlying mechanisms remain poorly understood. Aldoketoreductase type 1C3 (AKR1C3) is an important source of adipose androgen generation, activating androstenedione to testosterone (T). We postulated that AKR1C3 plays a critical role linking androgen metabolism and...

ea0034oc3.2 | Steroids | SFEBES2014

5α-reductase is a regulator of glucocorticoid action and metabolic phenotype in human liver

Nasiri Maryam , Nikolaou Nikolaos , Parajes Silvia , Bujalska Iwona , Gathercole Laura , Tomlinson Jeremy

Patients with GC excess (Cushing’s syndrome) develop central obesity, insulin resistance and hepatic steatosis. The A-ring reductases (5α-reductase type 1 (5αR1) and 2 (5αR2)) generate dihydrotestosterone from testosterone, but importantly also inactivate cortisol and are highly expressed in human liver. We propose that 5αR may regulate GC exposure and therefore may modulate metabolic phenotype in human liver.Primary human hepato...

ea0034oc3.4 | Steroids | SFEBES2014

Pre-receptor glucocorticoid metabolism across human ageing: the impact of gender and menopausal status

Hassan-Smith Zaki , Morgan Stuart , Sherlock Mark , Hughes Beverly , Lavery Gareth , Tomlinson Jeremy , Stewart Paul

Introduction: There is growing evidence that 11β-HSD1 expression/activity increases with age in key target tissues including adipose tissue, bone, and skin, implicating local amplification of glucocorticoids in the pathophysiology of related disease. We have previously shown that 11β-HSD1KO mice are protected from both the adverse metabolic effects of excess glucocorticoids and age-associated muscle weakness. We investigated changes in global activity and skeletal mu...

ea0034oc6.1 | Clinical | SFEBES2014

Adverse outcome in glucocorticoid induced adrenal suppression; an analysis of short synacthen tests in 2782 patients

Chapman Matthew , Argese Nicola , Mani Dhanasekaran , Dabhi Vijay , Boot Christopher , Crowley Rachel , Stewart Paul , Tomlinson Jeremy

2–3% of the UK population are prescribed glucocorticoid (GC) therapy and their adverse effects contribute to a significant health burden. Suppression of endogenous GC secretion is a recognized complication of therapy, but the magnitude of the problem, together with its clinical consequences have not been determined. We conducted a retrospective study across all specialties in a large secondary–tertiary care center identifying 2782 patients who underwent 3666 250 &#95...