Searchable abstracts of presentations at key conferences in endocrinology

ea0034p267 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

11β HSD1KO mice resist aged associated decline in markers of brown adipose tissue function

McCabe Emma , Doig Craig , Morgan Stuart , Larner Dean , Tomlinson Jeremy , Stewart Paul , Lavery Gareth

The primary function of brown adipose tissue (BAT) is to use lipids to generate heat through uncoupling of oxidative phosphorylation in mitochondria. Glucocorticoids (GC) have a negative effect upon BAT through inhibition of uncoupling protein 1 (UCP1) expression. Similarly, it has been reported that BAT levels decline with age and have been linked to age related accumulation of body fat, leading to the idea that improving BAT function during ageing could have a beneficial rol...

ea0034p272 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Liver fibrosis is common in Alstrom syndrome and can be identified using non-invasive tests

Hazlehurst Jonathan , Armstrong Matthew , Hodgkiss Jayne , Crowley Rachel , Geberhiwot Tarekegn , Newsome Phillip , Tomlinson Jeremy

Alstrom syndrome is an autosomal recessive ciliopathy that is characterised by increased body mass index, type 2 diabetes, retinal dystrophy, sensorineural hearing loss, cardiac fibrosis, and chronic kidney disease. Non-alcoholic fatty liver disease (NAFLD) in Alstrom patients ranges from simple steatosis, steatohepatitis and ultimately to fibrosis and cirrhosis. Nafld fibrosis score (http://nalfdscore.com/), enhanced liver fibrosis (ELF)-panel blood tests and Fibroscans are n...

ea0070aep275 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Female AKR1D1 knockout mice have impaired intestinal health with evidence of gut dybiosis, increased gut permeability and an increased incidence of colon cancer

Arvaniti Anastasia , Harris Shelley , Nikolaou Nikolaos , Potter Tom , Cox Roger , Odermatt Alex , Tomlinson Jeremy , Gathercole Laura

Metabolic syndrome (MS) is an important etiologic risk factor for the development and progression of certain cancers, including colorectal. Bile acids (BA) are potent antimicrobials that support gastrointestinal health and the dysregulation of BA homeostasis is thought to contribute to gut dysbiosis and drive endotoxemia. Furthermore, an increase in the cytotoxicity ofintestinal BA species can directly damage enterocytes and promote carcinogenesis. We have previously shown tha...

ea0070aep405 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Aldo-keto reductase (AKR) 1C1 – a potential driver of cell cycle progression in hepatocellular carcinoma

da Conceição Ismael , Nikolaou Nikolaos , Arvaniti Anastasia , Gathercole Laura , Hodson Leanne , Tomlinson Jeremy

The health burden associated with non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, continues to escalate. Not only is NAFLD associated with significant liver-specific and cardiovascular morbidity and mortality, but patients are at risk of the development of hepatocellular carcinoma (HCC); a malignancy where the incidence continues to rise and there are very limited therapeutic strategies.Aldo-keto reductase ...

ea0031oc1.4 | Young Endocrinologists prize session | SFEBES2013

A serum microRNA profile potentially associated with glucocorticoid mediated insulin resistance

Gathercole Laura , Doig Craig , Hazlehurst Jonathan , Borrows Sarah , Stewart Paul , Lavery Gareth , Tomlinson Jeremy

Patients with glucocorticoid (GC) excess develop insulin resistance and central obesity. We have demonstrated that GCs have tissue-specific effects on insulin sensitivity in humans, causing resistance in skeletal muscle but sensitivity in subcutaneous adipose tissue. The molecular mechanisms that underpin these differences remain poorly understood. Over the last decade small non-coding RNAs (microRNAs–miRNAs) controlling protein expression have been identified, representi...

ea0031p209 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The endocrine and metabolic characteristics of a large Bardet–Biedl syndrome clinic population

Mujahid Safa , Huda Mohammed , Forsythe Elizabeth , Hazlehurst Jonathan , Tomlinson Jeremy , Beales Philip , Carroll Paul , McGowan Barbara

Background: Bardet Biedl syndrome (BBS) is a rare autosomal recessive disorder caused by ciliary dysfunction. It is characterised by rod cone dystrophy, polydactyly, renal dysfunction, cognitive impairment. Endocrine consequences are thought to include hypogonadism, obesity and polyuria. However little is known about the endocrine and metabolic abnormalities in adult patients.Methods: One hundred and fifty-four patients with BBS were identified through t...

ea0031p332 | Steroids | SFEBES2013

Truncal fat distribution is associated with enhanced glucocorticoid excretion, increased 5α-reductase activity and higher insulin resistance independent of BMI in women with polycystic ovary syndrome

O'Reilly Michael , Hodson James , Crabtree Nicola , Hazlehurst Jon , Stewart Paul , Tomlinson Jeremy , Arlt Wiebke

Polycystic ovary syndrome (PCOS) is a clinical triad of anovulation, hyperandrogenism and insulin resistance. Patterns of fat distribution in PCOS may be associated with androgen activation, glucocorticoid metabolism and insulin resistance. Here we analysed the relationship between fat distribution, steroid metabolism and insulin resistance in women with PCOS.We compared results from 100 PCOS patients (Rotterdam criteria) with 80 sex- and BMI-matched con...

ea0028oc4.7 | Steroid | SFEBES2012

Glucocorticoids increase subcutaneous adipose tissue insulin sensitivity in vivo: a randomised double-blind, placebo controlled, cross over study

Hazlehurst Jonathan , Armstrong Matthew , Borrows Sarah , Gathercole Laura , Stewart Paul , Tomlinson Jeremy

Glucocorticoid (GC) excess, CushingÂ’s syndrome, is characterized by central obesity, proximal myopathy, insulin resistance and potentially type 2 diabetes mellitus. Current dogma dictates that GCs cause insulin resistance across all tissues. We have previously demonstrated that GCs cause insulin sensitization of human adipose tissue in vitro, whilst inducing insulin resistance in human skeletal muscle. No prior study has evaluated whether these observations transla...

ea0028p48 | Clinical practice/governance and case reports | SFEBES2012

A comparative quality assessment of evidence-based clinical guidelines in Endocrinology

Hazlehurst Jonathan , Armstrong Matthew , Sherlock Mark , O'Reilly Mick , Rowe Ian , Franklyn Jayne , Stewart Paul , Tomlinson Jeremy

Evidence-based clinical guidelines in Endocrinology attempt to improve and standardise patient care. There has been an expansion in guideline production although some of the heterogeneous methods used to assess the underlying evidence base may limit interpretation and implementation. Current and archived guidelines from The American Association of Clinical Endocrinologists (AACE), The Endocrine Society (ES), The American Thyroid Association, The British Thyroid Association and...

ea0028p201 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

24-hour urinary glucocorticoid metabolites are associated with hyperinsulinaemia independent of BMI in patients with the polycystic ovary syndrome

O'Reilly Michael , Hazlehurst John , Lebbe Marie , Stewart Paul , Tomlinson Jeremy , Arlt Wiebke

Polycystic ovary syndrome (PCOS) is a triad of insulin resistance, hyperandrogenism and anovulation. PCOS is associated with increased adrenocortical drive and 5alpha-reductase activity, which may have adverse metabolic consequences. Here we analysed the relationship of urinary androgen and glucocorticoid metabolite excretion with markers of insulin resistance in a large PCOS cohort. We compared results from 127 PCOS patients fulfilling Rotterdam diagnostic criteria with 100 B...