Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep535 | Endocrine-related Cancer | ECE2020

Endocrine related immune adverse events associated with programmed death ligand-1 (PD-L1) therapy in hematologic malignancies: A retrospective analysis

Lo Preiato Valentina , Buganè Anna , Casadei Beatrice , Argnani Lisa , Luigi Zinzani Pier , Pagotto Uberto , Pelusi Carla

Background: PD-L1 represents a novel class of drugs for treatment of a broad spectrum of malignancies including onco-hematologic diseases. This treatment is associated with several immuno-related adverse events (irAEs). Thyroid diseases and diabetes are among the most common PD-L1 endocrine-irAEs reported in solid cancers.Aims: To describe the frequency, the onset and the characteristics of PD-L1 endocrine-irAEs in patients with hematologic malignancies....

ea0070aep782 | Reproductive and Developmental Endocrinology | ECE2020

New data in turner syndrome: Results from a long-term prospective observational study from diagnosis to adulthood

Corzani Francesca , Cecchetti Carolina , Oriolo Claudia , Altieri Paola , Perri Annamaria , Scarano Emanuela , Mazzanti Laura , Pagotto Uberto , Gambineri Alessandra

Turner syndrome (TS), one of the most frequent chromosomal aberrations in females, is characterized not only by structural abnormalities (somatic and congenital) but also by acquired comorbidities, such as metabolic disorders, cardiovascular alterations, autoimmune diseases, osteoporosis, and malignancies. The prevalence of structural abnormalities that usually complicate TS at diagnosis is well known. However, the prevalence of acquired complications, that may appear at any a...

ea0070aep820 | Reproductive and Developmental Endocrinology | ECE2020

BMI may be a better predictor of cardiovascular risk than PCOS phenotype in a population of reproductive age PCOS patients

Pandurevic Srdjan , Pizzi Carmine , Fanelli Flaminia , Vicennati Valentina , Pelusi Carla , Di Dalmazi Guido , Pagotto Uberto , Gambineri Alessandra

Introduction: Women with polycystic ovary syndrome (PCOS) are considered to have increased risk of cardiovascular disease (CVD), even though the syndrome encompasses hugely varying phenotypes. Research into CVD prevention demonstrated a variety of biochemical and ultrasound (US) markers predicting risk in the general population, but those are sparsely utilised for PCOS, in part due to the patients’ therapeutic goals.Aim: To evaluate if PCOS type or...

ea0070aep999 | Thyroid | ECE2020

Pembrolizumab inducing thyroid diseases: Are there differences between patients treated for lung carcinomas and those for lymphomas?

Lo Preiato Valentina , Buganè Anna , Casadei Beatrice , Salvagni Stefania , Argnani Lisa , Ardizzoni Andrea , Luigi Zinzani Pier , Pagotto Uberto

Background: In the last years, Pembrolizumab has been used to treat solid and lymphatic neoplasms, showing improved patients’ survival. Due to its mechanism of action, Pembrolizumab may be responsible of several immune-related adverse events (irAEs). The most frequent endocrine-irAEs reported are thyroid diseases.Aims: The aim of this study was to evaluate differences in thyroid disease incidence and presentation between patients treated for lung c...

ea0026p13 | Adrenal cortex | ECE2011

Redefinition of age and sex specific reference intervals of eight serum steroids by liquid chromatography: tandem mass spectrometry (LC–MS/MS)

Fanelli F , Belluomo I , Di Lallo V D , Baccini M , Casadio E , Gasparini D Ibarra , Gambineri A , Pasquali R , Pagotto Uberto

The use of LC–MS/MS quantitative methods in clinical and research laboratories is becoming a well established reality that may overcome specificity and accuracy limits of immunoassays. Nevertheless, among different LC–MS/MS methods an agreement on the values that are to be considered normal or pathologic has not been reached yet, and this is mainly due to differences in LC–MS/MS methods, to the poor or absent availability of reference material and to the selecti...

ea0022p694 | Obesity | ECE2010

Reference interval values of four plasmatic endocannabinoids measured by isotopic dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)

Fanelli Flaminia , Cuomo Gaia , Di Lallo Valentina Diana , Belluomo Ilaria , Baccini Margherita , Gambineri Alessandra , Vicennati Valentina , Pasquali Renato , Pagotto Uberto

The endocannabinoid system is involved in modulating many metabolic and behavioural processes. Due to the instable nature of endocannabinoids in biological fluids and to the poor sensitivity of traditional analytical technologies, little is known about physiological circulating levels of these lipid mediators. We developed and validated an ID-LC-MS/MS method for the simultaneous measurement of four endocannabinoids: anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoyl-et...

ea0022p740 | Steroid metabolism & action | ECE2010

Simultaneous steroid measurement by isotopic dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS): comparison with routine analysis methods and reference intervals in normal subjects

Fanelli Flaminia , Belluomo Ilaria , Di Lallo Valentina Diana , Cuomo Gaia , Baccini Margherita , Vicennati Valentina , Gambineri Alessandra , Pasquali Renato , Pagotto Uberto

The development of a reliable and rapid method to simultaneously measure serum steroids represents a compelling challenge for modern endocrinology. Immunoassays are very sensitive methods, being widely employed in automated routine laboratories, lacking, however, in specificity due to cross-reactivity and matrix interference. Gas chromatography–mass spectrometry (GC-MS) constitutes the reference method for quantitative analysis of steroids, but time-consuming sample pre-t...

ea0056oc5.2 | Diving deep into adrenal cortex diseases | ECE2018

Steroid profiling by liquid chromatography tandem mass spectrometry in a large cohort of patients with adrenal incidentalomas

Di Dalmazi Guido , Fanelli Flaminia , Zavatta Guido , Rinaldi Eleonora , Casadio Elena , Bitti Silvia Ricci , Mezzullo Marco , Vicennati Valentina , Pagotto Uberto

Background: Steroid profiling by mass spectrometry (MS) provided novel insights into the pathogenesis of adrenocortical tumors and hypercortisolism. The aims of the study were (I) to analyze the steroid profiling by liquid chromatography-tandem MS (LC-MS/MS) in a large cohort of patients with adrenal incidentalomas and (II) to investigate the relationship between steroid profile and clinical outcomes.Methods: We included 307 patients with mono- and bilat...

ea0056p85 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Aortic root dilatation in primary aldosteronism: is treatment effective in reducing aortic damage?

Zavatta Guido , Dalmazi Guido Di , Pizzi Carmine , Rinaldi Eleonora , Casadio Elena , Bitti Silvia Ricci , Pasquali Renato , Pagotto Uberto , Vicennati Valentina

Introduction: Cardiovascular morbidity is more prevalent in primary aldosteronism (PA) than in essential hypertension. Preclinical studies have shown a possible association between ascending aorta dilatation and PA, probably mediated by the mineralocorticoid receptor.Patients and methods: A total of 84 patients attending the Endocrinology Unit of the S. Orsola-Malpighi University Hospital of Bologna, (Italy) were evaluated. Thirty-nine patients had a dia...

ea0056p645 | Endocrine Disruptors | ECE2018

Endocrine related adverse events associated with immune checkpoint blockade therapy: a retrospective analysis

Preiato Valentina Lo , Salvagni Stefania , Gianni Caterina , Ribichini Danilo , Bianchi Nicola , Pagotto Uberto , Ardizzoni Andrea , Pelusi Carla

Background: Immune checkpoint inhibitors (ICI) have become a clinically validated treatment for numerous types of tumor including melanoma, lung, and kidney carcinoma. These treatments can cause immune-related adverse events affecting several organs including the endocrine system.Aims: The aim of this study was to characterize the type and the onset of the ICI associated-endocrinopathies.Materials and methods: This retrospective co...