Searchable abstracts of presentations at key conferences in endocrinology

ea0056p927 | Female Reproduction | ECE2018

Disentangling polycystic ovary syndrome (PCOS) components by liquid-chromatography – tandem mass spectrometry (LC-MS/MS) steroid profiling

Fanelli Flaminia , Mezzullo Marco , Zanotti Laura , Fazzini Alessia , Mastroroberto Marianna , Morselli-Labate Antonio Maria , Pagotto Uberto , Pasquali Renato , Gambineri Alessandra

Introduction: Clinical and laboratory hyperandrogenisms indistinctly contribute to PCOS diagnosis; however, they differ in hormonal and metabolic correlates and require proper therapeutic strategies. Circulating biomarkers of hirsutism were not identified so far, with elevated testosterone being observed only in half of hirsute patients. Reasons for such inconsistencies possibly relies in previously used immunoassays, nowadays recognized as not adequate because of poor reliabi...

ea0081oc2.4 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Autonomous cortisol secretion in adrenal incidentalomas and risk of fragility fractures: a large cross-sectional study

Zavatta Guido , Vicennati Valentina , Altieri Paola , Colombin Giacomo , Coscia Kimberly , Fanelli Flaminia , Malagrino1 Matteo , Magagnoli Matteo , Tucci Lorenzo , Pagotto Uberto , Di Dalmazi Guido

Context: Autonomous cortisol secretion (ACS) has been associated with a higher prevalence of osteoporosis and fragility fractures in several studies. However, the data rely on heterogeneous studies and criteria for osteoporosis screening in this population are still debated.Objective: To assess the prevalence of fragility fractures and contributing factors in a large cohort of patients with adrenal incidentalomas.Methods: We review...

ea0081rc13.5 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Skeletal muscle mass in patients with adrenal incidentaloma

Colombin Giacomo , Vara Giulio , Fanelli Flaminia , Magagnoli Matteo , Tucci Lorenzo , Coscia Kimberly , Mosconi Cristina , Pagotto Uberto , Vicennati Valentina , Di Dalmazi Guido

Background and aim: The relationship between sarcopenia and overt cortisol excess as in Cushing’s syndrome is well-known. However, only a few studies investigated the relationship between autonomous cortisol secretion (ACS) in adrenal incidentalomas and skeletal muscle mass. The aims of our study were to analyze the skeletal muscle mass in patients with adrenal incidentalomas and to investigate the correlations with hormonal data.Methods: We enrolle...

ea0081p193 | Reproductive and Developmental Endocrinology | ECE2022

Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study

Pandurevic Srdjan , Dionese Paola , Mancini Ilaria , Mitselman Dmitri , Magagnoli Matteo , Teglia Rita , Gazineo Domenica , Godino Lea , Fanelli Flaminia , Cristina Meriggiola Maria , Pagotto Uberto , Gambineri Alessandra

Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype.Objective: This study compared the effects of a commercial VLCKD (...

ea0049ep1166 | Male Reproduction | ECE2017

Testosterone is poorly related to erectile dysfunction in young/middle aged human immunodeficiency virus-infected men

Vincentis Sara De , Santi Daniele , Decaroli Maria Chiara , Fanelli Flaminia , Mezzullo Marco , Fazzini Alessia , Ansaloni Anna , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: human immunodeficiency virus (HIV)-infection is strongly associated to erectile dysfunction (ED) in men. Preliminary data suggests that ED is poorly associated with serum T in HIV+ men.Aim: To investigate in HIV-infected men the relationship between sexual function as assessed by the validated International Index of Erectile Function (IIEF-15) and T deficiency using Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS).<p class="abste...

ea0049ep1381 | Thyroid (non-cancer) | ECE2017

BRAFV600E status and Stimulated Thyroglobulin at ablation time increase prognostic value of American Thyroid Association (ATA) classification systems for persistent disease in Differentiated Thyroid Carcinoma (DTC)

Repaci Andrea , Vicennati Valentina , Paccapelo Alexandro , Salituro Nicola , Cavicchi Ottavio , Monari Fabio , Tallini Giovanni , Gruppioni Elisa , Altimari Annalisa , Fiorentino Michelangelo , Pagotto Uberto

Background: Stimulated Thyroglobulin levels measured at the time of remnant ablation (Htg-A) and BRAFV600E mutation were shown to have prognostic value in predicting persistent disease in DTC. The aim of this study was to evaluate the prognostic role of Htg-A combined with BRAFV600E status in association with revised American Thyroid Association (ATA) risk stratification.Patients and methods: 620 patients treated for a DTC were included in this study wit...

ea0041ep784 | Obesity | ECE2016

The circulating fingerprint revealed by targeted metabolomic as biomarker of metabolic impairment in female overweight/obesity

Mezzullo Marco , Fanelli Flaminia , Fazzini Alessia , Baccini Margherita , Casadio Elena , Ibarra-Gasparini Daniela , Mazza Roberta , Vicennati Valentina , Fontanesi Luca , Pasquali Renato , Pagotto Uberto

The comprehension of the network of metabolic processes may help the understanding of the molecular pathways driving obesity and related complications. However this is a hard task due to the large number of actors and their complex interplay. We aimed at exploring by targeted metabolomic the circulating metabolite profile in lean (NW, n=42; BMI: 18.5–24.9 kg/m2) and age-matched overweight/obese (OB, n=37, BMI≥25.0 kg/m2), drug...

ea0070oc2.3 | Bone and Calcium | ECE2020

Prediction algorithm for persistent primary hyperparathyroidism after parathyroidectomy

Repaci Andrea , Vicennati Valentina , Salituro Nicola , Vandi Giulia , Zavatta Guido , Altieri Paola , Di Dalmazi Guido , Gambineri Alessandra , Pelusi Carla , Burgio Luca , Piccin Ottavio , Cavicchi Ottavio , Pagotto Uberto

Background: Primary hyperparathyroidism (PHPT) is characterized by an excessive secretion of the parathyroid hormone (PTH) with normal or high calcium levels. The gold standard therapy involves minimally invasive parathyroidectomy with intraoperative PTH (ioPTH) monitoring. Different criteria have been identified when predicting cure rates using ioPTH values.Objective: To evaluate the percent ioPTH drop (ΔioPTH), the post-excision ioPTH, the first p...

ea0070aep43 | Adrenal and Cardiovascular Endocrinology | ECE2020

CYP11B2 DNA methylation pattern is discordant in aldosterone-producing adenomas and in concurrent aldosterone-producing cell clusters

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Maffeis Valeria , Asioli Sofia , Vicennati Valentina , Pagotto Uberto , Fassina Ambrogio , Fallo Francesco

Background: Previous studies have shown an association between low CYP11B2 DNA methylation levels and high CYP11B2 mRNA levels in aldosterone-producing adenoma (APA), suggesting that epigenetic mechanisms play a pivotal role for regulating CYP11B2 function in primary aldosteronism. It has been proposed that aldosterone-producing cell clusters (APCCs) may become a source of autonomous aldosterone production when evolving into APA.Aim: Our aim was to deter...

ea0070aep881 | Thyroid | ECE2020

The diagnostic value of basal and calcium-stimulated procalcitonin for the diagnosis of medullary thyroid cancer: Preliminary results from a multicentric experience

Censi Simona , Di Stefano Marta , Repaci Andrea , Manso Jacopo , Pagotto Uberto , Bertazza Loris , Barollo Susi , Plebani Mario , Colombo Carla , Fugazzola Laura , Mian Caterina

Background: Calcitonin (CT) is the most sensitive marker for MTC diagnosis. By the way, many pre-analytical, analytical and post-analytical pitfalls worsen its accuracy. Procalcitonin (proCT), a CT precursor, has been suggested as a valuable complementary test in MTC diagnosis, given its stability and the reproducibility between different assay kits.Material and Methods: basal CT (bCT) and proCT (bproCT) and stimulated CT (bCT) and proCT (sproCT) (2&#821...