Searchable abstracts of presentations at key conferences in endocrinology

ea0083pno2 | Pituitary and Neuroendocrinology | EYES2022

Real-world use of intravenous hypertonic saline for hyponatraemia: a data-driven refinement of ESE guidelines

M. F. Arshad , A. Iqbal , J Weeks , A Munir , W Bennet

Background: The European Society of Endocrinology (ESE) published guidelines to standardise intravenous hypertonic saline (HTS) for severe symptomatic hyponatraemia in 2014. Two 150 mL boluses of 3.0% HTS are proposed, one after the other, to achieve an initial sodium rise of 5 mmol/l without waiting for an interval sodium result. ESE guidelines were adopted by our University Hospital in 2017. However, high rates of sodium overcorrection were observed, and the guidelines lacke...

ea0084ps1-04-31 | Thyroid Hormone Transporters and Development | ETA2022

The role of type 3 deiodinase in a human model for early brain development

Lopez Marti Anna , Gunhanlar Nilhan , Meima Marcel , Edward Visser W.

Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...

ea0086p362 | Reproductive Endocrinology | SFEBES2022

Clinical utility of GnRH analogues in female androgen excess: diagnostic and therapeutic implications

Madden Doyle Lauren , Cussen Leanne , McDonnell Tara , O'Reilly Michael W

Rare causes of severe androgen excess (AE) can present a diagnostic challenge to endocrinologists. Imaging may not identify occult ovarian pathology, and the detection of adrenal nodular disease may be indicative of incidental pathology. GnRH analogues can be used both as a medical treatment and as a diagnostic utility to confirm ovarian source, particularly in women with a preferential elevation of serum testosterone (T). In this case series, we present three cases highlighti...

ea0089p2 | Population Science | NANETS2022

Factors Impacting Survival Outcomes of Islet Cell Carcinoma

Chu Tiffany , Hu Robert W. , Silberstein Peter T.

Background: Islet cell carcinomas are low-grade tumors originating from the islets of Langerhans. Despite the indolent nature of these tumors, metastasis is often detected upon initial diagnosis, at which point the mean survival is approximately 2 years. In this study, we aim to investigate disparities that exist in these patients and how facility variables, patient demographics, and palliative care (PC) utilization contribute to differences in survival outcomes.<p class="...

ea0089p3 | Population Science | NANETS2022

Socioeconomic Factors, Treatment Modality, and Survival in Islet Cell Carcinoma: A National Cancer Database Analysis

Hu Robert W. , Chu Tiffany , Silberstein Peter T.

Background: Islet cell carcinoma is a rare cancer of neuroendocrine origin. There has yet to be a study analyzing the treatment type and survival outcomes in this cancer. In this study, we utilized a national database to understand the correlations between patient demographics, socioeconomic factors, modality of treatment, and survival.Methods: The National Cancer Database was queried to identify patients diagnosed with islet cell carcinoma (ICD-O-3 hist...

ea0049ep1125 | Female Reproduction | ECE2017

Prenatal androgen exposure alters gene expression and promoter methylation of two ovarian follicle maturation factors

Jahromi Marziyeh Salehi , Tehrani Fahimeh Ramezani , Hill Jennifer W

Background: Follicles imaturation, as the hallmark of polycystic ovarian syndrome caused by prenatal androgen exposure, is suspected to be effected through expression changes of related genes. The aim of this study was to evaluate gene expression and promoter methylation of GATA6 and Follistatin (FST), two factors involved in follicle maturation, in adult female rats prenatally exposed to androgen excess by comparing them with non-treated rats.Material a...

ea0044p105 | Diabetes and Cardiovascular | SFEBES2016

Connexins and gap-junction mediated intercellular communication in the diabetic kidney

Hills Claire E , Price Gareth W , Squires Paul E

Background: Altered connexin expression and/or function is linked to the development and progression of secondary microvascular complications associated with diabetes. Despite this, we know little for the role of these small membrane proteins in the diabetic kidney. This study examines if glucose-evoked changes in TGF-β1 modulate connexin expression and gap junction-mediated intercellular communication in diabetic nephropathy.Methods: Biopsy materia...

ea0044p106 | Diabetes and Cardiovascular | SFEBES2016

Connexins, hemi-channels and ATP release in the diabetic kidney

Squires Paul E , Price Gareth W , Hills Claire E

Background: Changes in the expression of connexins have been linked to renal damage in diabetes and both hemi-channels and gap junctions represent potential therapeutic targets for the treatment of diabetic nephropathy. In the current study, we utilize model epithelial cells from human renal proximal tubules (HK2), to demonstrate a role for glucose and its downstream beta1 isoform of the pro-fibrotic cytokine transforming growth factor (TGFβ1) on connexin expression and h...

ea0037ep953 | Thyroid (non-cancer) | ECE2015

Safety and efficacy of rapid thyroid blockade with Lugol's iodine in the pre-surgical management of Graves' thyrotoxicosis

Mohammed Azmi , Elsaify W , Mukhtar Rasha , Nag Sath

Introduction: A significant number of patients are intolerant of anti-thyroid drugs (ATD) and thyroidectomy remains the only treatment option available to patients who decline radioiodine as definitive therapy. As patients with poorly controlled thyrotoxicosis are at risk of developing thyroid storm, optimal pre-operative control of hyperthyroidism is essential. Rapid thyroid blockade (RTB) with the contrast agents sodium ipodate and iopanoic acid were attractive treatment opt...

ea0037ep1047 | Thyroid (non-cancer) | ECE2015

TPOAb as an autoimmune response or index of thyroid hypofunction in breast cancer?

Smyth Peter , McDermott E W M , O'Higgins N J

The observed association between thyroid disorders and breast cancer has provoked many investigations. One area where there is some, although far from universal, agreement is the finding of an increased prevalence of anti-thyroid autoantibodies in breast cancer patients compared to controls. Whether this is a feature of a generalised autoimmune response to breast cancer, or provoked by the enzyme thyroid peroxidase acting as an autoantigen, remains unclear. In this study we lo...