Searchable abstracts of presentations at key conferences in endocrinology

ea0017p27 | (1) | BSPED2008

Long-term outcome of autosomal recessive pseudohypoaldosteronism

Bandhakavi M , Kirk J , Hogler W , Barrett T , Shaw N

Type 1 pseudohypoaldosteronism (PHA1), defined as resistance to aldosterone, is characterised by salt wasting, hyperkalemia and metabolic acidosis and is associated with high renin and aldosterone levels. The autosomal recessive form is characterised by generalised salt wasting and is due to a defect in the epithelial sodium channel. Whilst there are individual case reports on this condition, there are little published data on long-term outcome including neurodevelopment.<...

ea0017p52 | (1) | BSPED2008

Comparison of twice daily insulin and multiple daily insulin regimens in children and adolescents newly diagnosed with type 1 diabetes

Lyder G , Kirk J , Barrett T , Shaw N , Hogler W

Aims: To compare glycaemic control and change in body mass index (BMI) in children and adolescents newly diagnosed with type 1 diabetes (T1D) and started on either twice daily insulin (BD) or multiple daily insulin (MDI).Methods: This study looked retrospectively at all children newly diagnosed with T1D at our hospital from January 2006 to June 2007. There were 44 children and the outcome measures used were change in haemoglobin A1c (HbA1...

ea0016p76 | Bone and calcium | ECE2008

Seasonality, sun exposure, skin type and vitamin D levels influence Parathyroid Hormone related Peptide (PTHrP) metabolism during pregnancy and after delivery in mothers and their newborns

Siafarikas Aris , Bulsara Max K , Jones Timothy W

PTHrP is an important factor for the regulation of calcium homeostasis around delivery. The aim of this study was to longitudinally analyse PTHrP metabolism and influencing factors looking at mothers and their breastfed newborns from 32 weeks of pregnancy until 8 weeks after delivery. Nineteen families (8 Caucasian, 11 Arabic/Asian) participated in the study. We analysed PTHrP, 25 OH vitamin D, parathyroid hormone (PTH), alkaline phosphatase, albumin; serum and urine calcium, ...

ea0016p583 | Paediatric endocrinology | ECE2008

Comparison of vitamin D status, sun-exposure and personalised UVB-radiation dosimetry of mildly pigmented, breastfed newborns during their first 6-8 weeks of life in Perth, Western Australia and Berlin, Germany

Siafarikas Aris , Hesse Volker , Bulsara Max K , Jones Timothy W

The prevalence of vitamin D deficiency in at-risk groups is rising even in sunny countries. Aim of this study was to compare vitamin D status and effect of vitamin D supplementation of moderate risk (mildly pigmented, WHO skin type 2) breastfed newborns from sunny and temperate climate zones. Newborns in Perth (30°S, group 1:5 male, 6 female) did not receive any vitamin D supplementation, newborns in Berlin (52.5°N, 17 male, 23 female) were randomised into n=2...

ea0016p659 | Signal transduction | ECE2008

Ligand-dependent internalization of somatostatin receptors

van Vugt Harmke H , Schmid Herbert A , Sailer Andreas W

Somatostatin (somatotrophin release inhibiting factor; SRIF) is produced primarily in the hypothalamus and pancreas and inhibits the secretion of many hormones and neurotransmitters. Moreover, SRIF and SRIF analogs are able to inhibit tumor growth. Many human neuroendocrine and non-neuroendocrine tumors express the five known somatostatin receptors (sst1–5) in different amounts.Tachyphylaxis after prolonged treatment with octreotide (Sand...

ea0011p300 | Diabetes, metabolism and cardiovascular | ECE2006

The ethanolic extract of Combretum decandrum Roxb. improved glucose tolerance and increased glucose uptake of hyperinsulinemic rats

Pannangpetch P , Theansuwan W , Kongyingyoes B , Kukongviriyapan V , Kukongviriyapan U

Hyperinsulinemia leading to insulin resistance is the major factor in the pathogenesis of type 2 diabetes mellitus. And also defect in glucose uptake is among the primary defects associated with peripheral insulin resistance. Interestingly, the result from our previous study indicated that the ethanolic extract of Combretum decandrum Roxb. (CD) had a hypoglycemic effect in type 1 diabetic rat model. Therefore this study examined the effect of CD extract on the glucose t...

ea0011p406 | Diabetes, metabolism and cardiovascular | ECE2006

Dehydroepiandrosterone inhibits differentiation, proliferation and 11β-hydroxysteroid dehydrogenase type 1 activity in human preadipocytes

McNelis J , Bujalska IJ , Stewart PM , Arlt W

The adrenal steroid dehydroepiandrosterone (DHEA) has been shown in vivo, to mimic the effects of peroxosome proliferator-activated receptor (PPAR) ligands and oppose those of glucocorticoids, thus producing beneficial effects on insulin sensitivity and adipogenesis in obese and diabetic rodents. Furthermore, DHEA treatment has recently been shown to reduce subcutaneous and visceral fat in humans in vivo. However, the mechanism by which DHEA produces these anti-a...

ea0011p430 | Endocrine disruptors | ECE2006

Endocrine disorders in thallasaemia – local experience in an inner city hospital in Birmingham, England

Gangopadhyay KK , Das G , Burbridge W , Wright C , De P

Endocrinopathies are amongst the most common complications of thallasaemia, which is a hereditary disorder of haemoglobin synthesis and excessive iron deposition is thought to be the main reason.Our hospital serves a multiethnic population and consequently we see a substantial number of patients with thallasaemia who are screened for endocrine complications. Those found to have endocrine problems are reviewed in our joint thallasaemia-endocrine clinic. B...

ea0011p504 | Endocrine tumours and neoplasia | ECE2006

Headaches cured by surgery

Banerjee A , Balaratnam M , Dhillo W , Mendoza N , Meeran K

Headaches associated with acromegaly are common even after hypophysectomy. Medical treatment with dopamine agonists and Somatostatin analogues often help. We report two cases when pharmacological therapy failed but further surgical removal of residual pituitary tissue cured the headaches.A 38 year-old lady presented with an eight year history of headaches, unresponsive to simple analgesia. Acromegaly was confirmed by a raised serum growth hormone (GH) 33...