Searchable abstracts of presentations at key conferences in endocrinology

ea0007p39 | Diabetes, metabolism and cardiovascular | BES2004

A randomised controlled trial of laser treatment among hirsute women with polycystic ovary syndrome

Clayton W , Lipton M , Sherr L , Rustin M , Elford J

Objective: To evaluate the impact of laser treatment on the severity of facial hirsutism as well as psychological morbidity in women with polycystic ovary syndrome (PCOS).Methods: Randomised controlled trial of 5 high fluence treatments (intervention) or 5 low fluence treatments (control) over 6 months. 88 women with facial hirsutism due to PCOS were recruited from hospital outpatient clinics and a patient support group in 2002. Main outcomes were self r...

ea0007p57 | Diabetes, metabolism and cardiovascular | BES2004

Protective effects of phytoestrogens against oxidative stress in human endothelial cells

Zhong W , Adams I , Adams R , Atkin S

Background Phytoestrogens are a group of biologically active plant substances with chemical structures similar to that of endogenous estrogen. Their beneficial effects on cardiovascular protection have been indicated by the relatively lower incidence of cardiovascular diseases in people with higher phytoestrogen consumption. Recent studies show that they have anti-oxidative properties, which have not been studied in human endothelial cells under different glucose conditions.</...

ea0007p88 | Endocrine tumours and neoplasia | BES2004

Ovarian stromal luteoma - a rare cause of postmenopausal virilization diagnosed by selective ovarian venous sampling

Nag S , Cruickshank D , Jackson T , Leen B , Kelly W

Virilization in post-menopausal women is usually the result of androgen production by ovarian or adrenal tumours. Androgen secreting tumours account for less than 1 % of all ovarian tumours and include granulosa cell tumours, thecomas, lipoid cell tumours and luteomas. We present a case of an occult virilizing ovarian luteoma diagnosed by selective ovarian venous sampling.A 68 year old nulliparous woman presented with a 15 month history of hirsutism and ...

ea0007p120 | Endocrine tumours and neoplasia | BES2004

BIM-23244, a somatostatin analogue with high affinity for somatostatin receptors 2 and 5, inhibits endothelial proliferation in vitro

Adams R , Adams I , Zhong W , Lindow S , Atkin S

Somatostatin (SST) modulates exocrine and endocrine secretion, proliferation and apoptosis, via 5 transmembrane receptors (SSTRs 1 to 5), which predominantly signal through inhibitory G proteins. Stable analogs such as Lanreotide and Octreotide have been developed for use in clinical practice. Both have high affinity for SSTR 2, and moderate affinity for SSTR 5. Octreotide has been shown to inhibit endothelial proliferation, probably via SSTR 2, which is expressed by prolifera...

ea0007p151 | Neuroendocrinology and behaviour | BES2004

Downward resetting of the osmotic threshold for thirst in patients with syndrome of inappropriate antidiuretic hormone

Smith D , Moore K , Tormey W , Baylis P , Thompson C

The syndrome of inappropriate antidiuretic hormone (SIADH) is characterised by euvolamic hyponatraemia. Patients with SIADH continue to drink normal amounts of fluid, despite plasma osmolalities well below the physiological osmotic threshold for the onset of thirst. The regulation of thirst has not been previously studied in SIADH. We studied the characteristics of osmotically-stimulated thirst and vasopressin (AVP) secretion, and the non-osmotic suppression of thirst and AVP ...

ea0007p154 | Neuroendocrinology and behaviour | BES2004

Prevalence of hypopituitarism in survivors of traumatic brain injury

Agha A , Rogers B , Tormey W , Phillips J , Thompson C

Recent evidence suggests a high prevalence of neuroendocrine dysfunction in patients following traumatic brain injury (TBI), but dynamic anterior pituitary assessment were performed in relatively small number of patients and posterior pituitary function remains poorly investigated.We studied 102 consecutive patients (84 males) who had survived severe or moderate TBI [initial Glasgow Coma Scale (GCS) score 3-13] at a mean (+/- standard deviation) of 19 +/...

ea0006s13 | Melanocortin receptors | SFE2003

Role of Brainstem Melanocortin System in CCK-mediated Satiety

Fan W , Ellacott K , Halatchev I , Takahashi K , Cone R

In addition to expression in the arcuate nucleus of the hypothalamus, POMC is also expressed in a group of neurons in the caudal aspect of the nucleus of the solitary tract, the primary site of synapse of vagal afferent fibers. To test the hypothesis that the brainstem POMC neurons may be involved in satiety signaling, we assessed whether genetic or pharmacological blockade of MC4-R could attenuate the ability of CCK to inhibit food intake. CCK-8s was administered to female C5...

ea0005oc1 | Reproduction and Development | BES2003

Agonists of peroxisome proliferator-activated receptor-gamma (PPARgamma) regulate steroidogenesis in a human granulosa cell line (HGC-5)

Berdiaki A , Jonard S , Chatterjee V , Rainey W , Franks S

Peroxisome proliferator-activated receptor-gamma (PPARgamma) is one of the isoforms of the PPAR-family of nuclear hormone receptors. Ligand activated PPARs dimerise with retinoid X receptor and act as transcription factors translating nutritional, pharmacological and metabolic stimuli into changes in the expression of genes. PPARgamma is thought to serve several roles in adipocyte differentiation, fatty acid and lipid metabolism and insulin sensitivity. PPARgamma has also been...

ea0005p5 | Bone | BES2003

Determination of a correlation between release of beta c-terminal telopeptides and area of resorption by recombinant rankl-generated human osteoclasts

Chan B , Buckley K , Dutton J , Gallagher J , Fraser W

The discovery of the fundamental involvement of receptor activator for nuclear factor-KB ligand (RANKL) in osteoclast (OC) formation, has enabled the routine generation of human OCs in vitro from human peripheral blood mononuclear cells (PBMCs). Beta C-terminal telopeptide (beta-CTx) is a specific resorption marker for degradation of bone type I collagen by OCs. We have evaluated the correlation between beta-CTx released from dentine wafers on which OC were c...

ea0005p14 | Clinical Case Reports | BES2003

Combined pituitary hormone deficiency (CPHD) with adult-onset corticotropin deficiency but without evidence for PROP-1 or HESX1 mutations

Hammer F , Hahner S , Allolio B , Arlt W

Combined pituitary hormone deficiency (CPHD) denotes impaired production of growth hormone (GH) and of one or more other pituitary trophic hormones. Distinct subtypes of CPHD have been shown to be due to mutations in different homeobox transcription factors, which are involved in pituitary development and organogenesis. So far, only PROP-1 and HESX1 mutations have been associated with CPHD comprising corticotropin deficiency. Here we report two patients with a novel form of CP...