Endocrine Abstracts

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W Arlt, School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK AbstractProf. Wiebke Arlt received her undergraduate medical training at the University of Cologne in Germany. She obtained her MD degree in 1993 with distinction and trained in General Medicine and Endocrinology and Diabetes at the University Hospital Würzburg under th...

W Wiersinga, University of Amsterdam, Amsterdam, The Netherlands AbstractWilmar M Wiersinga obtained his MD in Amsterdam in 1969 and his Board Certification in Internal Medicine in 1976. He obtained his PhD cum laude in 1979 at the University of Amsterdam on the thesis ‘The peripheral conversion of T4 into T3 and reverse T3’. Thereafter he spent two years as a research fellow at the UCLA with professors David...

Introduction: At the start of insulin pump therapy usually only a single basal rate, one insulin correction factor and one carbohydrate ratio are prescribed. Not only does this approach fail to match normal physiology but experience gained over 5 years of providing an insulin pump service found that these settings invariably needed early and frequent adjustment. As a result algorithms were developed to give a more precise pattern of basal rates and correction factors.<p cl...

Introduction: For years we have used data downloaded from blood glucose meters (BGM) in our diabetes clinic as an aid for discussion and management. Unfortunately allowing free choice of BGM needs several different download programmes and cables, introducing unnecessary complexity and delay. DIASEND® developed by the Swedish company Aidera AB represents a possible solution.Methods: DIASEND® combines hardware and software with a secure internet ...

One of the fundamental mysteries of biology has been the genetic control of puberty in the human. High degrees of species specificity in the control of GnRH secretion, the central actor in sexual maturation, and the rarity of a discrete period of childhood quiescence independent of suckling in most animals have compounded this problem.The clinical condition of Idiopathic Hypogonadotropic Hypogonadism, either with normosmia (nIHH)) or with anosmia (Kallma...

Soy and red clover extracts contain high concentrations of isoflavones, particularly of genistein, which bind to both estrogen receptors α and ß (ERα and ERß). Lifelong nutrition rich in soy proteins or soy protein isolates appear to exert positive effects on certain health aspects including the development of mammary cancer but the beneficial effects become questionable when soy/isoflavone-rich nutrition starts in later adult life. Stimulatory effects on m...

Intact PTH [PTH(1–84)] measurements separate hypercalcaemic patients into 1) a parathyroid cause (usually 1°HPT) from 2) non-parathyroid causes (usually hypercalcaemia of malignancy). Improved sensitivity increases confidence in diagnosing hypoparathyroidism. PTH RIAs had problems with C-terminal PTH fragments and in renal failure circulating PTH (35–84) persists for hours giving high RIA PTH. Intact PTH is retained in renal failure and this resulted in new ap...

Prevention of autoimmune thyroid disease (AITD) might become feasible in the future.Preventive intervention requires accurate prediction. AITD frequently runs in families, and twin studies have shown that genes contribute to a large extent to the risk of Graves' hyperthyroidism (GH) and Hashimoto's hypothyroidism (HH). However, CTLA-4 and HLA genes confer only a small risk, and the nature of the polygenetic background remains largely unknown. The impact of environmental factor...

Wylie Vale, Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California, USA Abstract Wylie Vale is the Helen McLoraine Professor of Molecular Neurobiology and Head of the Clayton Foundation Laboratories for Peptide Biology at the Salk Institute for Biological Studies, where he is currently Chair of the Faculty. He is also an Adjunct Professor of Medicine at the Un...