Searchable abstracts of presentations at key conferences in endocrinology

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0038oc4.3 | Diabetes and cardiometabolic complications | SFEBES2015

5α-tetrahydrocorticosterone exhibits topical anti-inflammatory action with limited adverse effects on angiogenesis

Gastaldello Annalisa , Livingstone Dawn E , Tsang Nicola , Walker Brian R , Hadoke Patrick W , Andrew Ruth

Background: The 5α-reduced glucocorticoid, 5α-tetrahydrocorticosterone (5α-THB), displays a dissociated steroid profile exhibiting anti-inflammatory effects in a murine model of thioglycollate-induced peritonitis but failing to induce adverse metabolic effects caused by corticosterone. We assessed the topical anti-inflammatory properties of 5α-THB in a model of irritant dermatitis. Given the adverse effects of steroids on cutaneous wound healing, we also in...

ea0038oc4.4 | Diabetes and cardiometabolic complications | SFEBES2015

Hyperinsulinaemia due to inhibition of 5α-reductases is ameliorated by liver-selective glucocorticoid receptor antagonism in diet-induced obesity

Mak Tracy C S , Livingstone Dawn E W , Walker Brian R , Andrew Ruth

Background: 5α-reductase 1 (5αR1) metabolises steroids such as glucocorticoids and androgens, and is highly expressed in murine liver. Genetic disruption of 5αR1 leads to adverse metabolic changes in mice. We hypothesised that dutasteride, a 5αR inhibitor, induces insulin resistance in mice, as in humans, and this effect is underpinned by increased hepatic glucocorticoid action; an experimental paradigm was set up using A-348441, a liver-selective glucocort...

ea0038p140 | Growth and development | SFEBES2015

Hormonal control of β-cell proliferation in fetal ovine pancreatic islets in vitro

Harris Shelley E , Kelly Amy , Davis Melissa A , Anderson Miranda , Forhead Alison J , Limesand Sean W

Hormonal control of pancreatic β-cell development in the fetus during late gestation remains unclear. In fetal sheep hypothyroidism causes an increase in pancreatic β-cell mass in association with increased plasma insulin and leptin concentrations. This study investigated the effects of triiodothyronine (T3), insulin and leptin on proliferation rates in fetal ovine pancreatic β-cells in vitro.All procedures were approve...

ea0038p409 | Steroids | SFEBES2015

Shocking? A systematic review of adrenal insufficiency in adults on oral steroids

Hunter Louise , Joseph Rebecca M , Ray David W , Dixon William G

Background: One percent of the adult population are, at any one time, prescribed oral glucocorticoids (GC). GCs are known to be associated with hypothalamic–pituitary–adrenal axis suppression. However, there remains uncertainty regarding: i) the prevalence of GC-induced adrenal insufficiency (AI); ii) the effects of GC dose and duration; and iii) the time course of adrenal recovery and how GCs should be withdrawn. We undertook a systematic literature review to addres...

ea0037gp.13.01 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Investigating chemerin/CMKLR1 signalling as a novel link between obesity and inflammatory bowel disease

Dranse Helen J , Rourke Jillian L , Stadnyk Andrew W , Sinal Christopher J

Background: Chemerin is a recently identified adipocyte-secreted signalling molecule (adipokine) that regulates adipocyte differentiation, metabolism, and inflammation through activation of the cognate receptor Chemokine-Like Receptor 1 (CMKLR1). Circulating chemerin levels are increased in obese patients as well as in patients with inflammatory bowel disease (IBD) such as Crohn’s disease and ulcerative colitis. Increased white adipose tissue mass (WAT) and resultant chan...

ea0058p081 | Diabetes | BSPED2018

Introduction of carbohydrate counting from diagnosis is associated with significant reduction in HbA1c in children with type 1 diabetes

Saranga Shyam S M , Henderson David , Thomas Vicky , Copley Sian , Hopper Neil W

Introduction: NICE NG18 recommends level 3 carbohydrate counting from diagnosis for CYP diagnosed with Type 1 Diabetes. Our unit introduced in-patient level 3 carb counting from day 1 in 2015 in response to an audit demonstrating sub-optimal control in the first year of treatment.Methods: We carried out a longitudinal study of HbA1c in paediatric patients during the first year of diagnosis in two time periods, before and after the introduction of carb co...

ea0034p345 | Steroids | SFEBES2014

Role of estrogen hormone in lipopolysaccharide: induced Alzheimer's disease in female rats; possible underlying mechanisms and modulation by progesterone hormone

Abdelwahed O M , Gamal M , Abdelwahab Z , Zickri M , El Eraky W , Saleh D O

The incidence of Alzheimer’s disease (AD) is higher in women than men. Our study aimed to investigate the behavioral, biochemical, and histological changes in lipopolysaccharide (LPS)-induced AD, to study effect of estrogen in AD clarifying the possible involved underlying mechanisms and its modulation by progestsserone. Groups: Female albino rats were divided into control, AD, AD+ovariectomy (OVX), AD+OVX+estrogen replacement and AD+OVX+estrogen+pr...

ea0070oc2.5 | Bone and Calcium | ECE2020

Effect of nine months of vitamin D supplementation on areal and volumetric bone mass density and bone architecture in graves’ disease: a double-blinded, randomized clinical trial

Grove-Laugesen Diana , Ebbehoj Eva , Watt Torquil , Würgler Hansen Klavs , Rejnmark Lars

Background: Vitamin D is important to skeletal health and is standard care in conditions with low BMD. Thyrotoxicosis caused by Graves’ disease (GD) leads to increased bone turnover and reduced BMD. We aimed to test the hypothesis that vitamin D supplementation would improve bone recovery in GD.Methods: Using a double-blinded design, hyperthyroid patients with a first time diagnosis of GD were randomized to supplementation with vitamin D3 70 mg/day...

ea0070aep667 | Pituitary and Neuroendocrinology | ECE2020

Gender differences in airway obstruction in men and women with acromegaly: A longitudinal study

Störmann Sylvère , Schilbach Katharina , Amereller Felix , W Angstwurm Matthias , Schopohl Jochen

Introduction: Acromegaly is a slowly progressing systemic disease that leads to numerous changes in metabolism and organ function. A large cross-sectional study showed signs of subclinical airway obstruction in female patients. We performed a longitudinal study of lung function testing to compare parameters of airway obstruction in male and female patients with acromegaly over time.Methods: 40 patients with acromegaly (24 male, 16 female) underwent repea...