Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1113 | Neuroendocrinology | ICEECE2012

Retinal growth hormone: local regulation by GH-releasing hormone (GHRH)?

Harvey S. , Qiang W. , Lin W. , Sanders E.

Introduction: The (GH) gene, identical to that in the pituitary, is expressed in retinal ganglion cells (RGCs) in chickens, rats, mice and humans. Retinal GH is a neuroprotective factor, as it promotes RGC survival and, in humans, the concentration of GH in vitreous fluid may be a marker for ocular disease. Increasing retinal GH expression could thus have therapeutic potential. The factors regulating retinal GH expression are, however, unknown. The possibility that GH-releasin...

ea0029p1657 | Thyroid (non-cancer) | ICEECE2012

miRNA expression of the thyroid after goiter formation and involution using different iodine regimens

Mao J. , Chong W. , Shan Z. , Teng W.

Background: Thyroid damage is known to occur during experimental iodine-induced goiter. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression. Dysregulation of specific miRNAs can interfere with tissue homeostasis. The purpose of this study was to investigate the dynamic expression profiles of miRNAs during adequate or mild-excess iodine supplementation in the iodine-deficient thyroid.Methods: Hyperplastic goiter was induced ...

ea0026p37 | Adrenal cortex | ECE2011

Thoracic and gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) and the ectopic ACTH syndrome (EAS)

Kamp K , Alwani A , Feelders R A , de Herder W W

Introduction: The ectopic ACTH syndrome (EAS) is associated with a variety of malignancies, mostly of (neuro-)endocrine origin. Several series report on the relative contribution of EAS in the spectrum of Cushing’s syndrome. However, information on the incidence/prevalence of EAS in the setting of patients diagnosed with thoracic or gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) is virtually absent.Study design: In our tertiary academic ...

ea0011p748 | Steroids | ECE2006

Prenatal diagnosis of the “low-oestriol” disorders Smith-Lemli-Opitz syndrome (SLOS), oxidoreductase deficiency (ORD) and sulfatase deficienciy (STSD)

Shackleton CHL , Craig W , Arlt W , Marcos J

Introduction: Unconjugated oestriol (uE3) is often measured in maternal serum during second trimester prenatal screening. While oestriol itself has little physiological importance, low values can indicate the presence of a disorder in feto-placental synthesis with potential health implications. Fetal steroids pass through the maternal circulation and into the urine so analysis of maternal fluids can be used for diagnosing causes of low oestriol.<p class="...

ea0009p214 | Clinical | BES2005

Use of etomidate for control of severe hypercortisolism

Moyes V , Wat W , Akker S , Drake W , Monson J

Etomidate, an imidazole derived anaesthetic agent, potently inhibits adrenocortical 11-beta-hydroxylase at non-hypnotic doses in Cushing's syndrome. We report its use in controlling hypercortisolism in a patient with aggressive Cushing's disease requiring pelvic surgery for endometrial carcinoma.IJ, a 42-year old female was diagnosed with Cushing's disease in 1998 in Malaysia. 8am cortisol was 800nmol/l, midnight cortisol 659nmol/l and ACTH 103ng/l. MRI ...

ea0029oc3.3 | Diabetes Clinical | ICEECE2012

Diabetic ketoacidosis at diagnosis influences complete remission after treatment of hematopoietic stem cell transplantation in adolescents with type 1 diabetes

Gu W. , Hu J. , Zhu D. , Tang W. , Li L. , Cui W. , Hong J. , Zhang Y. , Wang W. , Ning G.

Objective: To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was worthwhile to do in type 1 diabetes adolescents with diabetic ketoacidosis at diagnosis.Research Design and Methods: We enrolled 28 type 1 diabetes patients aged 14–30 years in a prospective AHSCT phase II clinical trial. Hematopoietic stem cells were harvested from the peripheral blood following a pretreatment consisting of a combination of cy...

ea0026p415 | Thyroid (non cancer) | ECE2011

Free T4 results in neonates: large differences between Immulite/VISTA and Vitros ECi

Weerkamp F , Wulkan R W

Introduction: Thyroxine is essential for growth and brain development in neonates. Early detection of hypothyroidism by measurement of free T4 (fT4) is therefore paramount. Moreover, the initial monitoring of Thyrax suppletion requires accurate fT4 measurements.Methods: In the Maasstad Hospital fT4 has been measured with the Immulite 2500 and from 2010 onward with the Dimension VISTA. Both instruments show good...

ea0011oc34 | Neuroendocrinology and neoplasia | ECE2006

Transgenic mice overexpressing Urocortin 3 show increased anxiety- and depressive-like behaviours but a hyporesponsive ACTH response to stress

Jamieson PM , Chen A , Vale W

Urocortin 3 is a CRF-related ligand highly specific for the Corticotropin-Releasing Factor Receptor Type 2 (CRFR2). CRFR2 is implicated in the regulation of stress-related behaviours and the neuroendocrine response to stressors. Close anatomical association between major Urocortin 3 terminal fields and CRFR2 in the limbic system and hypothalamus indicate this system is well placed to be involved in modulating of the physiological stress response. Transgenic mice ubiquitously o...

ea0003p29 | Clinical Case Reports | BES2002

Self-hypophysectomy - and return to normal

Stewart A , Connolly V , Kelly W

Introduction. We present a rare and unusual case of direct trauma to the pituitary region.History. A 22 year old female, 8 weeks post-partum, fell downstairs on to a metallic clothes drier. A metal spike 3mm wide and approximately 20cm long penetrated her right eyebrow. Computed tomography showed a haemorrhagic track involving the hypothalamic region, and extending to the left internal capsule. Irritability and instability of vital signs necessitated in...

ea0084ps1-04-34 | Thyroid Hormone Transporters and Development | ETA2022

The dawning of deiodinases: an outer ring deiodinase activity in the social amoeba dictyostelium discoideum with high affinity for reverse t3

Meima Marcel , Schaap Pauline , Edward Visser W.

Background: Conservation of genes involved in TH transport, metabolism and action can reveal clues about the origins of TH signaling. A deiodinase homologue (DdDio) was previously identified in the social amoeba Dictyostelium discoideum (Singh, 2014). Dictyostelium cells live as single cell amoebae in soil where they feed on bacteria. However, upon starvation a developmental program is initiated that results in the formation of a multicellular fruiti...