Searchable abstracts of presentations at key conferences in endocrinology

ea0007p263 | Clinical case reports | BES2004

A case of the pituitary resistance to thyroid hormone successfully treated with bromocriptine

Zieleniewski W , Kolodziej-Maciejewska H , Krawczyk Z

Pituitary resistance to thyroid hormone is a very rare cause of hyperthyroidism. It is characterized by normal, or elevated TSH concentration with high concentration of thyroxine and triiodothyronine.Here, we present a case of a 24-year-old woman who suffered from mild thyrotoxicosis and diffuse goiter for ten years. For several years she was under treatment with methimazole, but without any significant improvement, apart from the enlargement of the thyr...

ea0007p270 | Clinical case reports | BES2004

Truly rare - a true hermaphrodite

Arutchelvam V , Kelly W , Wolstenholme J

INTRODUCTION:True hermaphroditism is rare but has been reported in more than 400 individuals.Thediagnosis requires the presence of both ovarian and testicular tissue in either the same or opposite gonads.The external genitalia may simulate those of either a male or a female or may be ambiguous.Diagnosis and treatment at an early age is important .CASE REPORT:A 14 years old phenotypic ma...

ea0005p245 | Steroids | BES2003

Audit of adrenal vein sampling for primary aldosteronism

Sibal L , Raza A , Leen B , Kelly W

INTRODUCTION: Hypertension with hypokalaemia suggests primaryaldosteronism, which is confirmed by high plasma aldosterone with low renin concentrations. CT and MRI scans frequently fail to detect small primary aldosteronomas, and may incorrectly identify ' incidentalomas', so adrenal vein sampling is needed.AIM: To review the clincal and biochemical results on 12 patients who had catheter sampling of adrenal and ivc aldosterone(A) and Cortisol (C)with calculation of Aldosteron...

ea0005p248 | Steroids | BES2003

A non-invasive test of mild glucocorticoid resistance

Jerjes W , Wood P , Taylor N

For investigation of mild glucocorticoid resistance, dexamethasone may be inappropriate because, unlike cortisol, it crosses the blood-brain barrier and suitably low doses are difficult to titrate. Prednisolone has been proposed as an alternative but assay of cortisol as an endpoint is subject to cross-reaction with prednisolone in most ligand assays. Using capillary gas chromatography, we can distinguish urinary cortisol and prednisolone metabolites. We have compared this app...

ea0004p55 | Endocrine tumours and neoplasia | SFE2002

Improved 5 year actuarial survival rates in patients with prostate cancer managed by intermittent androgen suppression

Lane T , Ansell W , Oliver R

INTRODUCTIONWe assessed the long-term outcomes of patients managed with intermittent androgen suppression (IAS) following their enrolment in an open, non-randomised feasibility study initiated 10 years ago.PATIENTS AND METHODSAll patients were required to have been managed with androgen suppression for a minimum of 9 months and achieved PSA remissions to levels <4ng/ml. Therapy was stopped and the patients...

ea0003s13 | Recent Advances in Biological Rhythms | BES2002

Endocrine and other biological rhythms in man

Wehr T , Duncan|#Jr W , Aeschbach D

We carried out a series of experiments to identify common principles underlying the temporal organization of diverse circadian rhythms in endocrine and other functions in humans. Profiles of rhythms in plasma hormone levels, body temperature, and arousal state were measured while subjects remained at rest in continuous dim ( < 1 lux) light, after they had been exposed to artificial 'days' and 'nights' of different lengths. Subjects gave written informed consent for their pa...

ea0003p118 | Endocrine Tumours and Neoplasia | BES2002

Outcome of transphenoidal surgery by one surgeon for acute acromegaly

Akber M , Clayton R , Carlin W

Objective: Surgical outcome in acute acromegaly has been studied nationally and internationally with conflicting and variable results. Definition of cure varies from centre to centre.Rrecent studies have shown increased mortality in acromegalic patients with GH level >5mu/l. We studied the out come of transphenoidal surgery by a single surgeon at 6 and 12 moths after surgery to compare the results with other national and international published studies.Patients and methods...

ea0002p97 | Steroids | SFE2001


Jerjes W , Wood P , Taylor N

Acute cortisol increase in man, whether from endogenous or exogenous sources, is associated with changes in cortisol:cortisone equilibrium. We have examined these during normal daily circadian rhythms and following treatment with hydrocortisone. Following local ethical committee approval, four adult volunteers (2 male) collected urine samples over 3 hour periods starting from midnight and over hourly periods between 0600 & 0900 to define the morning cortisol peak. They pro...

ea0071005 | Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells | BES2020

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

C Berthault , W Staels , R Scharfmann

Objectives: The main endocrine cell types in pancreatic islets are alpha-, beta-, and delta-cells. Although these cell types have distinct roles in the regulation of glucose homeostasis, inadequate purification methods preclude the study of cell-type-specific effects. We aimed to develop a reliable approach that enables simultaneous sorting of live alpha-, beta-, and delta-cells from mouse islets for downstream analyses.Methods: We developed an antibody-...

ea0029oc12.5 | Obesity Clinical | ICEECE2012

Brown adipose tissue activation is inversely related with central obesity and metabolic parameters in adult human

Wang W. , Wang Q. , Zhang M. , Xu M. , Gu W. , Qi L. , Li B. , Ning G.

Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity and related metabolic risk. However, the supporting evidence in large population based studies is sparse.Methods: We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18–89 for BAT activities, visceral/subcutaneous fat areas and metabolic parameters. In vivo 18F-fluorodeoxygluc...