Searchable abstracts of presentations at key conferences in endocrinology

ea0003p150 | Endocrine Tumours and Neoplasia | BES2002

Patterns and mechanisms of hypercortisolism in association with phaeochromocytoma

Abraham P , Watson W , Park C , Philip S , Bandyopadhyay S , Acharya S , Talbot J , White A , Bevan J

Phaeochromocytoma in association with hypercortisolism is thought to be rare. However we have observed 4 cases in 3 years and question the rarity of this link. In each case there was a dominant adrenal mass (3.6-7.7cm) with contralateral adrenal hyperplasia. Three of the 4 tumours showed increased 123-I-mIBG uptake. Urinary catecholamines ranged from 872-22752nmol/24h (N < 600). Hypercortisolism was present in all 4 patients; sustained in 2 and cyclical in 2. Case 1 (JCEM ...

ea0086p70 | Metabolism, Obesity and Diabetes | SFEBES2022

Liver specific microparticles to improve islet transplantation outcomes in Type 1 diabetes

Walker Sophie , Lee I-ning , Gadd Victoria , Mellis David , Henderson John , Judge Amelia , Forbes Stuart , White Lisa , Forbes Shareen

Background: Islet transplant into the liver is a therapy for type 1 diabetes patients experiencing severe hypoglycaemia or impaired hypoglycaemic awareness. Widespread use is not currently considered due to the requirement for immunosuppression for the lifetime of the graft, and the attrition in graft function over the following 1-5 years. Following transplant into the liver, inflammation results in >60% islet loss, with few patients achieving insulin independence. The liv...

ea0087p1 | Poster Presentations | UKINETS2022

Second primary malignancies in patients with a neuroendocrine neoplasm in England

Russell Beth , E White Benjamin , Rous Brian , Wong Kwok , Bouvier Catherine , Srirajaskanthan Rajaventhan , Van Hemelrijck Mieke , K Ramage John

Background: Patients with neuroendocrine neoplasms (NENs) may often develop other malignancies. This study aimed to identify the frequency at which these second non-NEN malignancies occurred in England.Methods: Data was extracted from the National Cancer Registration and Analysis Service (NCRAS) on all patients diagnosed with a NEN at one of eight NEN site groups between 2012-2018: appendix, caecum, colon, lung, pancreas, rectum, small intestine and stom...

ea0081ep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Follow-up gestational diabetes in a telemedicine system in pandemic COVID19

Delgado Garcia Esther , Perez Lopez Paloma , Sanchez Ibanez Marta , Nieto Maria , De Marcos White Lourdes , Santader Cartagena Amelia , de Luis Roman Daniel

Background: Gestational diabetes mellitus (GDM) is common complication in pregnancy. During pandemic COVID-19, endocrine service iniciate telemedicine in medical care and monitoring blood glucose.Purpose: The purpose of this study was to asses metabolic control and pregnancy outcome during pregnancy in telematic consult.Materials and Methods: Descriptive study of 20 patients were assesed in telematic review in the first wave of the...

ea0065p133 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Tumour detection and outcomes of surveillance screening in SDHB and SDHD mutation carriers

White Gemma , Masucci Michael , Anandappa Samantha , Joshi Mamta , McGowan Barbara , Obholzer Rupert , Jacques Audrey , Christodoulou Dimitra , Izatt Louise , Velusamy Anand , Carroll Paul

Background: Pathogenic variants in genes encoding Succinate Dehydrogenase subunits B and D (SDHB/SDHD) predispose to Phaeochromocytoma and Paraganglioma (PPGL). Cascade genetic screening identifies relatives at risk and allows surveillance screening to enable early detection of PPGLs.Methods: Retrospective analysis of genetic databases and hospital records between January 2000 and December 2018 identified relatives carrying SDHB and <em...

ea0038p239 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Hypothalamic glucocorticoid levels increase in an in vivo model of glucocorticoid-induced obesity and hyperinsulinaemia

Sefton Charlotte , Harno Erika , Davies Alison , Small Helen , Allen Tiffany-Jayne , Wray Jonathan , Ramamoorthy Thanuja Gali , Coll Anthony P , White Anne

Glucocorticoid (Gc) excess, either endogenously produced (Cushing’s syndrome) or as a result of exogenous steroid treatment, can cause metabolic disorders such as obesity and hyperglycaemia. The contribution of centrally acting corticosterone in the development of these metabolic disorders is unknown. Gcs regulate the anorexigenic and orexigenic neuropeptides (POMC and AgRP) within the arcuate nucleus of the hypothalamus to modulate energy balance. This study investigated...

ea0035oc8.4 | Pituitary clinical | ECE2014

Normalization of urinary cortisol with the potent 11β-hydroxylase inhibitor LCI699 in patients with Cushing's disease: 22-week, multicentre, open-label study

Biller Beverly , Young Jacques , Hamrahian Amir , Fleseriu Maria , Molitch Mark , Pivonello Rosario , Shimatsu Akira , Shimizu Chikara , Tanaka Tomoaki , White Tracy , Hilliard Annie , Tian Chuan , Sauter Nicholas , Bertagna Xavier

Background: A proof-of-concept study (LINC 1) demonstrated that after 10 weeks, LCI699 normalized UFC in 11/12 patients with Cushing’s disease. This interim analysis of the first eight patients enrolled into a longer-term study (LINC 2) further evaluates LCI699 in Cushing’s disease; the full analysis on all 19 enrolled patients is expected in time for the congress.Methods: There were two study groups. Previous LINC 1 participants (follow-up coh...

ea0035p748 | Obesity | ECE2014

Bariatric surgery and bone loss: novel mechanisms and comparison of different modalities

Brzozowska Malgorzata , Bliuc Dana , Hong Angel , Jorgensen John , Talbot Michael , Rigas Georgia , Chen Weiwen , Pocock Nicholas , Eisman John , White Christopher , Baldock Paul , Center Jacqueline

Although bariatric surgery is the most effective weight loss therapy, its skeletal consequences are unclear. The aim of this study was to assess the impact of weight loss, gut hormones, adiponectin on bone loss in people undergoing Dieting (Diet), Gastric Banding (GB) and Gastric Sleeve (GS) over 24 months post-intervention.There were 15 Diet, 8 GB and 20 GS subjects with mean (±S.D.) age 53 (12) years and BMI 39 (6). At 12 months mea...

ea0034oc5.5 | Pituitary | SFEBES2014

Spatio-temporal analysis of prolactin gene transcription dynamics reveals short range co-ordination of lactotroph transcription activity in pituitary tissue

Featherstone Karen , Hey Kirsty , Momiji Hiroshi , McNamara Anne , Patist Amanda , Spiller David , Christian Helen , McNeilly Alan , Mullins John , Finkenstadt Barbel , Rand David , White Michael , Davis Julian

Mammalian genes display pulsatile transcription dynamics with bursts of expression occurring with variable duration and frequency. Using the human prolactin gene as a model of tissue specific gene regulation, we have characterised the transcription dynamics of this gene in cell lines, primary cells and pituitary tissue slices. Our data indicate that the tissue environment may have an important influence on cellular transcription activity. Cultures of cells from enzymatically d...

ea0027oc2.8 | Oral Communications 2 (Quick Fire) | BSPED2011

Novel SOX2 mutation: from clinical phenotype to identification of new molecular mechanisms of SOX2 action and interactions

Alatzoglou Kyriaki S , Andoniadou Cynthia L , Kelberman Daniel , Kim Hyoong-Goo , Pedersen-White Jennifer , Layman Lawrence , Martinez-Barbera Juan Pedro , Dattani Mehul T

Background: SOX2 is an early developmental transcription factor implicated in pituitary development. It consists of a N-terminal domain, a high mobility group (HMG)-DNA binding domain and a carboxyl-terminal domain. Heterozygous SOX2 mutations have been described in patients with a severe ocular phenotype and hypogonadotrophic hypogonadism (HH) with/without associated abnormalities. In vitro SOX2 interacts with β-catenin, a member of the Wnt signalling pathway, and...