Searchable abstracts of presentations at key conferences in endocrinology

ea0015p383 | Thyroid | SFEBES2008

Audit on thyroid function tests in acutely unwell patients

Thirumurugan Ethirajan , Kaur Tejinder , Jordaan Marieke , White Colin

Isolated change in serum TSH concentration occurs in 15% of hospitalised patients in response to non-thyroidal illness or various drugs, which interfere with thyroidal synthesis and secretion, thyroid hormone metabolism and absorption. Significant change in concentration of either suppressed (<0.1 mU/l) or elevated (>10 mU/l) TSH level is seen in 1–2% of them but only less than half have underlying thyroid disorder.UK Guideline for use of TF...

ea0013p11 | Bone | SFEBES2007

Alendronate accelerates increases in bone mineral density with growth hormone replacement but may attenuate the anabolic effect of growth gormone replacement on bone in adult growth hormone deficiency

White Helen , Ahmad Aftab , Durham Brian , Fraser William , Vora Jiten

Introduction: Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. Underlying mechanisms involved in the pathogenesis include reduced target-organ sensitivity to the effect of PTH. Growth Hormone Replacement (GHR) in AGHD leads to increased PTH target-organ sensitivity and consequently increased bone turnover and bone mineral density (BMD).Aims: We determined the effect of alendronate, given in addition to GHR, on PTH target-organ sens...

ea0013p162 | Diabetes, metabolism and cardiovascular | SFEBES2007

The importance of gene repression for metabolic regulation in human fat

Morganstein Daniel , Herzog Birger , White Roger , Parker Malcolm

The nuclear receptor co-factor RIP140 has an essential role in metabolic regulation. Genetically manipulated mice lacking RIP140 show reduced fat accumulation, increased energy expenditure and increased insulin sensitivity. They gain less weight on high fat feeding than wild type littermates, and are protected from both age and high fat diet induced insulin resistance.RIP140 is a repressor of transcription and in its absence metabolic gene networks are u...

ea0011p11 | Bone | ECE2006

PTH and phosphate circadian rhythms are altered in adult growth hormone deficient patients with low bone mineral density

White HD , Ahmad AM , Durham BH , Fraser WD , Vora JP

Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. PTH is secreted in a circadian rhythm and temporal fluctuations in PTH concentration, particularly at night, appear to be important in the regulation of bone turnover. Serum phosphate is an important determinant of PTH, with changes in phosphate preceding fluctuations in PTH concentration. We examined the difference in PTH and phosphate circadian rhythmicity in AGHD patients with normal and reduced bone mi...

ea0011p12 | Bone | ECE2006

Oral phosphate therapy used as an adjunct to growth hormone in adult growth hormone deficiency results in greater changes in bone mineral density compared with growth hormone replacement alone

White HD , Ahmad AM , Durham BH , Fraser WD , Vora JP

Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD) and bone turnover. Abnormalities in PTH circadian rhythmicity, including blunted nocturnal rise in PTH concentration have been reported in AGHD and may underlie the pathogenesis of osteoporosis. Serum phosphate is an important regulator of PTH, with changes in phosphate concentration preceding fluctuations in PTH. We examined the effect of oral phosphate therapy on PTH circadian rhythm...

ea0011p118 | Clinical case reports | ECE2006

Obesity, hypertension and elevated catecholamines

Joshi AA , Prabhakar VKB , White HD , Diver MJ , Vora JP

Human obesity is characterized by abnormalities in sympathetic cardiovascular control. We present two cases to demonstrate the relationship between weight, BP and catecholamines (UC).Case 1: A 39 year-old man reported symptoms of flushing and palpitations. His BMI was 50 kg/m2, consistent BP of 240/140 mmHg, with normal renal, thyroid function and normal fasting glucose. Urinary noradrenaline (UNA820 nmol/24 hrs) and dopamine (UDA-4500 nmol/24...

ea0011p632 | Neuroendocrinology and behaviour | ECE2006

Processing and sorting of pro-opiomelanocortin is an important checkpoint in regulating release of ACTH from secretory vesicles in pituitary cells

Warhurst A , Oliver RL , Davies RA , Pritchard LE , White A

Pro-opiomelanocortin (POMC) is endoproteolysed by prohormone convertase-1 (PC1) to ACTH within the secretory pathway in pituitary cells, where the regulation of ACTH release is essential for mediating the stress response. However POMC is present in the human circulation, indicating that not all POMC is processed. This suggests that regulation of trafficking and processing of POMC are important in determining ACTH release. To investigate this, we analysed steady-state release o...

ea0009oc29 | Oral Communication 4: Steroids | BES2005

Characterisation of a novel protein interacting with the glucocorticoid receptor

Rice L , Waters C , Garside H , White A , Ray D

Glucocorticoids (Gcs) exert their pleiotropic effects through activation of the ubiquitously expressed glucocorticoid receptor (GR). The mechanism of transcriptional activation by the GR involves interaction with co-modulator proteins. Glucocorticoid sensitivity is mediated by the expression level of these co-modulator proteins and GR concentration. Therefore, the aim of this study was to identify additional GR interacting proteins that may influence glucocorticoid sensitivity...

ea0009p125 | Endocrine tumours and neoplasia | BES2005

Oestrogen interacts with TNFalpha signalling pathways to stimulate human prolactin gene transcription

Adamson A , Friedrichsen S , Wilding M , White M , Davis J

Oestrogen is an important regulator of the pituitary hormone prolactin (PRL) in vivo, although the regulation mechanism is poorly understood. Liganded oestrogen receptor (ER) synergises with the pituitary specific factor Pit-1 on the rat PRL promoter to facilitate chromatin looping and increased transcription; however, no such mechanism has been reported for the human PRL promoter, in which the ERE sequence is altered.In pituitary GH3 cells stably transf...