Searchable abstracts of presentations at key conferences in endocrinology

ea0005s6 | Androgens and Prostate Cancer | BES2003

Androgen action in the prostate

White H , Gamble S , Odontiadis M , Bevan C

Prostate growth during development and at puberty is dependent on androgens. After puberty, growth ceases and the secretory function of the organ is maintained in the presence of high circulating testosterone levels. However, in cases of benign prostatic hyperplasia and prostate cancer, growth resumes inappropriately. Like normal prostate growth, tumour growth is initially androgen-dependent; hence, treatment involves removing circulating androgens by chemical castration and o...

ea0003oc44 | Neuroendocrinology | BES2002

MSH precursor peptides in rat cerebrospinal fluid: Evidence that pro-opiomelanocortin (POMC) processing is regulated with respect to energy balance

Pritchard L , Oliver R , McLoughlin J , Birtles S , Turnbull A , White A

Pro-opiomelanocortin (POMC) derived peptides coordinate energy balance via central melanocortin receptors. In order to monitor central POMC expression and processing in-vivo, we have quantified the POMC derived peptides ACTH, alpha-MSH and the high molecular weight precursors POMC/proACTH in rat cerebrospinal fluid (csf). POMC/proACTH levels were significantly lower in csf samples from fasted versus fed rats (65.2 ± 4.5 pmol/l versus 112 ± 10.1 pmol/l; p = 0.00...

ea0003p82 | Cytokines and Growth Factors | BES2002

IGFBP-5 regulates IGF-I mediated signaling and survival in the mouse mammary gland

Marshman E , Streuli C , Green K , White A , Westwood M

Insulin-like growth factor (IGF-I) is an important signal for mammary gland development and epithelial cell survival. Following lactation, the mammary gland undergoes involution through extensive epithelial cell apoptosis and thus, the IGF-I survival signal must be inhibited. IGF actions are regulated by association with high affinity binding proteins (IGFBPs) and the aim of this study was to investigate the expression of IGFBPs during mouse mammary gland development to determ...

ea0077p26 | Bone and Calcium | SFEBES2021

Pre-antiresorptive therapy dental screening (PADS): a successful intervention against medication related osteonecrosis of the jaws (MRONJ)

White Gillian , Hughes Caitlin , Burnside Lesley , Munro Robin , Chong Zhuo Min

Introduction: MRONJ is defined as exposed bone in the maxillofacial region that persists after eight weeks in patients treated with antiresorptive or anti-angiogenic drugs, without previous radiotherapy. The estimated United Kingdom incidence of MRONJ in osteoporosis patients is 0.01-0.1% (1). MRONJ can cause severe disfigurement, speech and feeding difficulties. We aim to investigate MRONJ incidence and utility of dental screening in patients receiving Zoledronate ...

ea0078OC5.1 | Oral Communications 5 | BSPED2021

Evaluating UK Referral Criteria for Children with Short Stature in a Tertiary Paediatric Endocrinology Centre

White Gemma , Cosier Shakira , Andrews Afiya , Willemsen Ruben H. , Savage Martin O. , Storr Helen L.

Background: Childhood growth monitoring aims to identify growth failure and detect underlying pathology. According to UK guidance, height <-2.7 standard deviation score (SDS) (<0.4th percentile) is used as the referral threshold. Additional referral criteria include height deficit (HSDS-target height SDS) <-2.0 and height velocity (HV) SDS <-1.3. Lack of routine HV and mid-parental height calculation, combined with stricter cut-offs compared to other European c...

ea0081rc5.6 | Rapid Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Effects of bariatric surgery and dietary intervention on changes in insulin resistance and appetite hormones over the period of 3 years

Brzozowska Malgorzata , Isaacs Michelle , Bliuc Dana , Baldock Paul , Eisman John , White Chris , Greenfield Jerry , Center Jacqueline

Objectives: Little is known about the mechanisms responsible for improvement in insulin resistance after bariatric surgery. We examined the impact of three types of bariatric surgery, in comparison with dietary intervention (DIET) on concurrent changes in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and appetite hormones over the period of 3 years. We also investigated the weight loss independent hormonal effects on insulin resistance.Me...

ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushing’s disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushing’s syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushing’s Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...

ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushing’s disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushing’s syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushing’s Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...