Searchable abstracts of presentations at key conferences in endocrinology

ea0068oc3 | Abstracts | UKINETS2019

Incidence and prevalence of neuroendocrine neoplasms reported in England from 2015 to 2017

White Benjamin E , Bouvier Catherine , Genus Tracey , Rous Brian , Srirajaskanthan Rajaventhan , Chandrakumaran Kandiah , Ramage John K

Introduction: Previously published UK Cancer Registry data showed incidence of Neuroendocrine Neoplasms rising between 2001 and 2015. This was higher than had been thought (Genus et al.). We report more recent data with more accurate coding (ICD-O-3).Aim: To analyse National Cancer Registration and Analysis Service (NCRAS) data on Neuroendocrine Neoplasias (NENs) in England including years 2015–2017.Methods: Public He...

ea0046p14 | (1) | UKINETS2016

Perioperative carcinoid crisis during surgery-who benefits from octreotide?

ElGendy Khalil , Johnnson Sarah , French Jeremy , White Steven , Charnley Richard , Manas Derek , Wilson Colin

Introduction: Carcinoid crisis, as an entity is poorly defined, but can be seen in patients with small bowel NET tumours after open bowel surgery or tumour unrelated procedures as cardiovascular instability (CI). Recent evidence suggests that cardiovascular instability (CI) during NET surgery is more common than previously considered.Aims and methods: We audited the incidence of CI during procedures and determined the relationship to perioperative octreo...

ea0046p24 | (1) | UKINETS2016

Improving outcomes for patients with resectable small bowel NET tumours; 5 year experience from a tertiary centre

ElGendy Khalil , Johnson Sarah , French Jeremy , White Steven , Charnley Richard , Manas Derek , Wilson Colin

Introduction: There remains controversy about which patients benefit from removal of their primary small bowel tumour and whether this should be performed in a specialist tertiary referral hospital as an elective procedure. Part of the decision making and consenting process in patients with metastases will be a shared decision about surgery with the patient in light of symptoms, morbidity from surgery and survival. The aim of this study was to elucidate important institution s...

ea0038p200 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

AMPK activators modulate pro-inflammatory responses in human adipocytes

White Anna , Mancini Sarah , Nguyen Dinh Cat Aurelie , Montezano Augusto , Salt Ian , Touyz Rhian

Adipose tissue inflammation may be an important mechanism in the development of systemic insulin resistance, such that modulation of this system may be a therapeutic target for type 2 diabetes and obesity-related disorders. AMPK has anti-inflammatory properties, yet the anti-inflammatory actions of AMPK in adipocytes remain poorly characterised. We questioned whether AMPK activation influences pro-inflammatory responses in cultured adipocytes in basal and stimulated conditions...

ea0037oc5.3 | Steroids, developmental and paediatric endocrinology | ECE2015

Activators of AMP-activated protein kinase regulate adipocyte aldosterone secretion and mineralocorticoid receptor signalling

White Anna , Cat Aurelie Nguyen Dinh , Montezano Augusto , Salt Ian , Touyz Rhian

The increasing global prevalence of obesity requires urgent intervention to limit the anticipated surge of associated cardiometabolic morbidity and mortality. The energy sensor AMP-activated protein kinase (AMPK) is one proposed target for treating metabolic disorders and is downregulated in adipose tissue of obese insulin resistant individuals. Given the strong relationship between metabolic syndrome and overactivity of the renin-angiotensin-aldosterone system (RAAS) we inves...

ea0037gp.22.05 | Pituitary–Therapy of Cushing's disease | ECE2015

Effects of osilodrostat (LCI699) on cytochrome P450 enzymes in healthy volunteers indicates a low drug–drug interaction potential

Ting Lillian , Tripathi Anadya Prakash , Darstein Christelle , White Tracy , Sauter Nicholas

Introduction: In vitro assessments of osilodrostat (LCI699), a potent oral inhibitor of 11β-hydroxylase suggested potential drug–drug interactions (DDIs) with cytochrome P450 (CYP) enzyme metabolism. This clinical study evaluated the effect of osilodrostat on the pharmacokinetics (PK) of CYP1A2, CYP2C19, CYP2D6, and CYP3A4 probe substrates, caffeine, omeprazole, dextromethorphan, and midazolam, respectively.Methods: A single-centre, op...

ea0034p171 | Neoplasia, cancer and late effects | SFEBES2014

Neuroendocrine biomarkers change with treatment in small cell lung cancer

Meredith Suzanne , Bryant Jennifer , Babur Muhammad , Riddell Philip , Williams Kaye , White Anne

Small cell lung cancer (SCLC) is distinguished by its neuroendocrine phenotype and secretion of hormone biomarkers. Tumours initially respond well to therapy but almost invariably relapse with a therapy-resistant phenotype. We have previously described pro-opiomelanocortin (POMC) as a potential biomarker of SCLC. In this study, we investigated how POMC acts as a biomarker of tumour response to treatment.SCLC cells (DMS 79) were injected subcutaneously in...

ea0031oc4.3 | Obesity, metabolism and bone | SFEBES2013

Adult offspring of undernourished sheep exhibit epigenetic alterations in HPA axis glucocorticoid receptor

Begum Ghazala , Stevens Adam , Oliver Mark , Jaquiery Anne , Harding Jane , Challis John , Bloomfield Frank , White Anne

Maternal programming increases the risk of alterations in the offspring’s HPA axis. Previously we showed that maternal undernutrition in sheep induces epigenetic changes in the glucocorticoid receptors (GR) within hypothalamic energy balance pathways, without affecting HPA axis GR. However, these studies focussed on fetal tissues1. Here, we investigated whether GR is epigenetically altered in the HPA axis of adult offspring to determine the status of the pathwa...

ea0031p185 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Knockdown of brain 11β-HSD1 does not lower body weight or improve insulin sensitivity

Harno Erika , Cottrell Elizabeth C , DeSchoolmeester Joanne , Turnbull Andrew V , Leighton Brendan , White Anne

Glucocorticoids act on several major neuropeptide networks in the hypothalamus which are important for regulation of energy balance and insulin sensitivity. Active glucocorticoids (cortisol/corticosterone in humans/rodents) can be regenerated from their inactive forms by the enzyme 11β-hydroxysteroid dehydrogenase type one (11β-HSD1) which is expressed in the hypothalamus. Therefore we decreased 11β-HSD1 expression in the brain to investigate the role of regener...

ea0030p38 | (1) | BSPED2012

Cushing's syndrome due to POMC secretion from an abdominal yolk sac tumour in a 2 year old child

Gevers Evelien , Shah Pratik , Meredith Suzanne , Torpiano John , Slater Olga , White Anne , Dattani Mehul

Cushing’s syndrome due to ectopic ACTH production is extremely rare in childhood. Ectopic ACTH secretion is most often due to tumours in the chest, but rare cases of carcinoid tumours, neuroblastoma, phaeochromocytoma and pancreatic and ovarian carcinoma have been reported. We describe a 2 year old girl with ectopic Cushing’s syndrome due to a malignant epithelial abdominal tumour producing POMC. She presented with rapid weight gain, hypertension, body odour, letharg...