Endocrine Abstracts

Aim: The relationship between hyperprolactinoma and insulin resistance has been shown in many studies. It is also known that hyperprolactinoma causes changes in carbohydrate and lipid metabolism. The aim of our study is to evaluate insulin resistance in patients with prolactinoma and see the effect of treatment on insulin resistance and karotis intima media thickness (CIMT).Material and methods: Twenty-two female patients diagnosed biochemically and radi...

Objective: Hyperprolactinemia is reported to be associated with impaired glucose metabolism, and low-grade inflammation. There is some data regarding increased oxidative stress- particularly protein oxidation in the conditions like metabolic syndrome or diabetes, but not in hyperprolactinemic subjects in the literature. We aimed to investigate advanced oxidation protein product (AOPP) levels-an established marker of protein oxidation and antioxidant thiol levels in hyperprolac...

Objective: To know the GH secretory function in surgically cured acromegaly and its impact on quality of life of the patients.Subjects and methods: Sixty-seven acromegalics were judged to be surgically cured according to the Cortina consensus criteria and underwent postoperative insulin tolerance test (ITT) provoking hypoglycemia with nadir blood sugar under 50 mg/dl. All the patients underwent surgery under combined microscopic and endoscopic observatio...

Back ground: Encouraging responses of pituitary adenomas and pituitary carcinomas to temozolomide treatment have been well described and loss of immunopositivity of O6-methyl-guanine-DNA methyltransferase (MGMT) reportedly serves a predictor of good response. Recently some nonresponsive cases, however, also appeared. We describe here our own experiences of temozolomide treatment on three aggressive pituitary tumors.Subjects and methods: Three pitu...

Purpose: To know the relationship between gsp mutations and clinico-pathological features in GH producing pituitary adenomas.Subjects and methods: Somatotropinomas resected from 43 acromegalic patients, 18 males and 25 females, were examined for gsp mutation analysis. The mutation was detected in 25 of 43 (58.1%) tumours with alternations of Arg to Cys in codon 201 (68%), Arg to Ser in codon 201 (8%), Gln to Leu in codon 227 (20%) and Gln to Arg in codon...

Introduction: Hyperprolactinemia has been associated with dyslipidaemia, hypercoagulability, impaired endothelial function and decreased insulin sensitivity. Recent data show that prolactin hormone (PRL) could contribute to atherogenesis. The aim of our study was to investigate the relationship between MPV and PRL, androgen hormones, lipid profiles in premenopausal prolactinoma patients, who did not have insulin resistance (IR).Methods: Thirty-nine newly...

Introduction: Sterotactic radiosurgery (SR) has been used to treat recurrent adenomas and also as a primary treatment. The objective is to evaluate long-term tumor control, development of hypopituitarism and other side effects in the follow-up.Patients and method: Retrospective analysis of 21 patients with non-functioning pituitary adenomas (NFA) treated with modified linear accelerator (LINAC) between 1998 and 2009 in three tertiary Spanish hospitals. C...

Introduction: Sterotactic radiosurgery (SR) has been used to treat recurrent adenomas after failure of medical and surgical procedures and also as a primary treatment. The aim of this paper is to evaluate long-term control of functioning pituitary adenomas (FPA).Patients and method: Thirty-eight patients with FPA treated with modified linear accelerator (LINAC) between 1998 and 2009 in three tertiary Spanish hospitals. Hormonal control was defined as hor...

Introduction: Impaired glucose tolerance and diabetes mellitus are frequently seen complications of acromegaly. Insulin resistance due to chronic growth hormone (GH) excess and inhibition of insulin and glucagon secretion by long-acting somatostatin analogues (SA) used in the treatment are the main reasons of the impaired glucose tolerance.Objective: To determine the effect of long-acting SA treatment on glucose homeostasis regarding the insulin resistan...

Background: Cushing’s disease is associated with high morbidity and mortality, and there are currently no approved medical therapies. Twice-daily pasireotide sc showed efficacy in patients with mostly moderate-to-severe (UFC≥2×ULN) Cushing’s disease in a large, randomized, double-blind, 12-month trial. A monthly long-acting release (LAR) formulation of pasireotide has been developed to provide a smoother pharmacokinetic profile, potentially a better effica...